Jatrophane diterpenes as inhibitors of chikungunya virus replication: Structure-activity relationship and discovery of a potent lead

Journal of Natural Products

Volumn 77, Issue 6, 2014, Pages 1505-1512

  Nothias Scaglia, Louis Félix ^a,b   Retailleau, Pascal ^b   Paolini, Julien ^a   Pannecouque, Christophe ^c   Neyts, Johan ^c   Dumontet, Vincent ^b   Roussi, Fanny ^b   Leyssen, Pieter ^c   Costa, Jean ^a   Litaudon, Marc ^b  

^a UNIVERSITÉ DE CORSE   (France)

^b INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3,5,7,15 TETRAACETOXY 2 HYDROXY 8 ISOBUTYRYLOXY 9,14 DIOXOJATROPHA 6 (17),11E DIENE; 3,5,7,15 TETRAACETOXY 2 HYDROXY 8 TIGLOYLOXY 9,14 DIOJATROPHA 6 (17),11E DIENE; 3,5,7,15 TETRAACETOXY 8 BENZOYLOXY 2 HYDROXY 9,14 DIOXOJATROPHA 6 (17),11E DIENE; 3,5,7,8,15 PENTAACETOXY 2 HYDROXY 9,14 DIOXOJATROPHA 6 (17),11E DIENE; 5,7 DIACETOXY 3 BENZOYLOXY 14,15 DIHYDROXY 8 (2 METHYLBUTYRYLOXY) 9 OXOJATROPHA 6 (17),11E DIENE; 5,7 DIACETOXY 3 BENZOYLOXY 14,15 DIHYDROXY 8 ISOBUTYRYLOXY 9 OXOJATROPHA 6 (17),11E DIENE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIMETABOLITE; ANTIVIRUS AGENT; DITERPENE; ESTER DERIVATIVE; JATROPHANE DITERPENE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHIKUNGUNYA ALPHAVIRUS; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG SELECTIVITY; EUPHORBIA; EUPHORBIA AMYGDALOIDES; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; NONHUMAN; SEMLIKI FOREST ALPHAVIRUS; SINDBIS VIRUS; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; X RAY ANALYSIS;

ALPHAVIRUS INFECTIONS; ANTIVIRAL AGENTS; CHIKUNGUNYA VIRUS; DITERPENES; EUPHORBIA; FRANCE; HIV-1; HIV-2; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SEMLIKI FOREST VIRUS; SINDBIS VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84903649961     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np500271u     Document Type: Article

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