Oral phosphorus supplementation secondarily increases circulating fibroblast growth factor 23 levels at least partially via stimulation of parathyroid hormone secretion

Journal of Nutritional Science and Vitaminology

Volumn 60, Issue 2, 2014, Pages 140-144

  Takasugi, Satoshi ^a   Akutsu, Miho ^a   Nagata, Masashi ^a  

^a MEIJI DAIRIES CORPORATION   (Japan)

Author keywords

Cinacalcet; Fbroblast growth factor 23; Parathyroid hormone; Phosphorus supplementation

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; CINACALCET; FIBROBLAST GROWTH FACTOR 23; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; PHOSPHORUS; TERIBONE; UNCLASSIFIED DRUG; FIBROBLAST GROWTH FACTOR; NAPHTHALENE DERIVATIVE; PHOSPHATE; PHOSPHATE INTAKE;

ANIMAL EXPERIMENT; BLOOD CHEMISTRY; BLOOD SAMPLING; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HORMONE DETERMINATION; HORMONE RELEASE; NONHUMAN; NOTE; PHOSPHATE BLOOD LEVEL; RAT; SINGLE DRUG DOSE; ANIMAL; BLOOD; HUMAN; METABOLISM; PHARMACOLOGY; PHOSPHATE INTAKE; SECRETION (PROCESS); WISTAR RAT;

ANIMALS; DIETARY SUPPLEMENTS; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; NAPHTHALENES; PARATHYROID HORMONE; PHOSPHATES; PHOSPHORUS; PHOSPHORUS, DIETARY; RATS, WISTAR; RECEPTORS, CALCIUM-SENSING;

EID: 84903631249     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.60.140     Document Type: Note

References (30)

1. Dhingra R, Sullivan LM, Fox CS, Wang TJ, D'Agostino RB Sr, Gaziano JM, Vasan RS. 2007. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 167: 879-885.
2. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G. 2005. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 112: 2627-2633.
3. Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM. 2000. Phosphate regulation of vascular smooth muscle cell calcifcation. Circ Res 87: E10-17.
4. Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S, Yamashita T. 2004. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19: 429-435.
5. Memon F, El-Abbadi M, Nakatani T, Taguchi T, Lanske B, Razzaque MS. 2008. Does Fgf23-klotho activity infu-ence vascular and soft tissue calcifcation through regulating mineral ion metabolism? Kidney Int 74: 566-570.
6. Nasrallah MM, El-Shehaby AR, Salem MM, Osman NA, El Sheikh E, Sharaf El Din UA. 2010. Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcifcation in haemodialysis patients. Nephrol Dial Transplant 25: 2679-2685.
7. Gutiérrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, Smith K, Lee H, Thadhani R, Jüppner H, Wolf M. 2008. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 359: 584-592.
8. Jean G, Terrat JC, Vanel T, Hurot JM, Lorriaux C, Mayor B, Chazot C. 2009. High levels of serum fbroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients. Nephrol Dial Transplant 24: 2792-2796.
9. Mirza MA, Larsson A, Melhus H, Lind L, Larsson TE. 2009. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis 207: 546-551.
10. Faul C, Amaral A P, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feld-man HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro O M, Kusek JW, Keane MG, Wolf M. 2011. FGF23 induces left ventricular hypertrophy. J Clin Invest 121: 4393-4408.
11. Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Taniguchi A, Sato T, Shuto E, Nashiki K, Arai H, Yama-moto H, Takeda E. 2006. Acute effect of oral phosphate loading on serum fbroblast growth factor 23 levels in healthy men. Kidney Int 70: 2141-2147.
12. López I, Rodríguez-Ortiz ME, Almadén Y, Guerrero F, de Oca AM, Pineda C, Shalhoub V, Rodríguez M, Aguilera-Tejero E. 2011. Direct and indirect effects of parathyroid hormone on circulating levels of fbroblast growth factor 23 in vivo. Kidney Int 80: 475-482.
13. Reeves PG, Nielsen FH, Fahey GC Jr. 1993. AIN-93 purifed diets for laboratory rodents: fnal report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.
14. Fox J, Lowe SH, Conklin RL, Nemeth EF. 1999. The calci-mimetic NPS R-568 decreases plasma PTH in rats with mild and severe renal or dietary secondary hyperpara-thyroidism. Endocrine 10: 97-103.
15. Nemeth EF, Steffey ME, Hammerland LG, Hung BC, Van Wagenen BC, DelMar EG, Balandrin MF. 1998. Calcimi-metics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci USA 95: 4040-4045.
16. Nemeth EF, Heaton WH, Miller M, Fox J, Balandrin MF, Van Wagenen BC, Colloton M, Karbon W, Scherrer J, Shatzen E, Rishton G, Scully S, Qi M, Harris R, Lacey D, Martin D. 2004. Pharmacodynamics of the type II calci-mimetic compound cinacalcet HCl. J Pharmacol Exp Ther 308: 627-635.
17. Rodriguez M, Nemeth E, Martin D. 2005. The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism. Am J Physiol Renal Physiol 288: F253-F264.
18. Li X, Liu H, Qin L, Tamasi J, Bergenstock M, Shapses S, Feyen JH, Notterman DA, Partridge NC. 2007. Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem 282: 33086-33097.
19. Thomsen AR, Smajilovic S, Bräuner-Osborne H. 2012. Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling. Curr Drug Targets 13: 1324-1335.
20. Almaden Y, Canalejo A, Hernandez A, Ballesteros E, Garcia-Navarro S, Torres A, Rodriguez M. 1996. Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro. J Bone Miner Res 11: 970-976.
21. Nielsen PK, Feldt-Rasmussen U, Olgaard K. 1996. A direct effect in vitro of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells. Nephrol Dial Transplant 11: 1762-1768.
22. Slatopolsky E, Finch J, Denda M, Ritter C, Zhong M, Dusso A, MacDonald PN, Brown AJ. 1996. Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro. J Clin Invest 97: 2534-2540.
23. Hernández A, Concepción MT, Rodríguez M, Salido E, Torres A. 1996. High phosphorus diet increases pre-proPTH mRNA independent of calcium and calcitriol in normal rats. Kidney Int 50: 1872-1878.
24. Kilav R, Silver J, Naveh-Many T. 1995. Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest 96: 327-333.
25. Estepa JC, Aguilera-Tejero E, López I, Almaden Y, Rodriguez M, Felsenfeld AJ. 1999. Effect of phosphate on parathyroid hormone secretion in vivo. J Bone Miner Res 14: 1848-1854.
26. Lavi-Moshayoff V, Wasserman G, Meir T, Silver J, Naveh-Many T. 2010. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol 299: F882-F889.
27. Liu S, Tang W, Zhou J, Stubbs JR, Luo Q, Pi M, Quarles LD. 2006. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol 17: 1305-1315.
28. Rodriguez-Ortiz ME, López I, Muñoz-Castañeda JR, Martinez-Moreno JM, Ramírez A P, Pineda C, Canalejo A, Jaeger P, Aguilera-Tejero E, Rodriguez M, Felsenfeld A, Almaden Y. 2012. Calcium defciency reduces circulating levels of FGF23. J Am Soc Nephrol 23: 1190-1197.
29. Saji F, Shigematsu T, Sakaguchi T, Ohya M, Orita H, Maeda Y, Ooura M, Mima T, Negi S. 2010. Fibroblast growth factor 23 production in bone is directly regulated by 1{alpha},25-dihydroxyvitamin D, but not PTH. Am J Physiol Renal Physiol 299: F1212-F1217.
30. Saito H, Maeda A, Ohtomo S, Hirata M, Kusano K, Kato S, Ogata E, Segawa H, Miyamoto K, Fukushima N. 2005. Circulating FGF-23 is regulated by 1alpha,25-dihy-droxyvitamin D3 and phosphorus in vivo. J Biol Chem 280: 2543-2549.