Solution structure of the major factor VIII binding region on von Willebrand factor

Blood

Volumn 123, Issue 26, 2014, Pages 4143-4151

  Shiltagh, Nuha ^a   Kirkpatrick, John ^a   Cabrita, Lisa D ^a   McKinnon, Tom A J ^b   Thalassinos, Konstantinos ^a   Tuddenham, Edward G D ^a,c   Hansen, D Flemming ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; TRYPSIN INHIBITOR; VON WILLEBRAND FACTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLOGICAL ACTIVITY; BLEEDING TENDENCY; CHEMICAL STRUCTURE; COMPLEX FORMATION; HUMAN; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; VON WILLEBRAND DISEASE;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FACTOR VIII; HUMANS; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY; VON WILLEBRAND FACTOR;

EID: 84903605238     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-07-517086     Document Type: Article

References (48)

1. Tuddenham EG, Lane RS, Rotblat F, et al. Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease. Br J Haematol. 1982;52(2):259-267. (Pubitemid 12033978)
2. Weiss HJ, Sussman II, Hoyer LW. Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease. J Clin Invest. 1977;60(2):390-404. (Pubitemid 8154146)
3. Sadler JE. Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem. 1998; 67(1):395-424. (Pubitemid 28411134)
4. Goodeve AC. The genetic basis of von Willebrand disease. Blood Rev. 2010;24(3):123-134.
5. Zhou Y-F, Eng ET, Nishida N, Lu C, Walz T, Springer TA. A pH-regulated dimeric bouquet in the structure of von Willebrand factor. EMBO J. 2011;30(19):4098-4111.
6. Zhang Q, Zhou Y-F, Zhang C-Z, Zhang X, Lu C, Springer TA. Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci USA. 2009;106(23):9226-9231.
7. Brondijk THC, Bihan D, Farndale RW, Huizinga EG. Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex. Proc Natl Acad Sci USA. 2012;109(14):5253-5258.
8. Foster PA, Fulcher CA, Marti T, Titani K, Zimmerman TS. A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor. J Biol Chem. 1987;262(18):8443-8446.
9. Zhou Y-F, Eng ET, Zhu J, Lu C, Walz T, Springer TA. Sequence and structure relationships within von Willebrand factor. Blood. 2012;120(2): 449-458.
10. Hampshire DJ, Goodeve AC. The international society on thrombosis and haematosis von Willebrand disease database: an update. Semin Thromb Hemost. 2011;37(5):470-479.
11. Piétu G, Ribba AS, Chérel G, et al. Epitope mapping of inhibitory monoclonal antibodies to human von Willebrand factor by using recombinant cDNA libraries. Thromb Haemost. 1994;71(6):788-792. (Pubitemid 24177971)
12. Jorieux S, Gaucher C, Piétu G, Chérel G, Meyer D, Mazurier C. Fine epitope mapping of monoclonal antibodies to the NH2-terminal part of von Willebrand factor (vWF) by using recombinant and synthetic peptides: interest for the localization of the factor VIII binding domain. Br J Haematol. 1994;87(1):113-118. (Pubitemid 24207008)
13. Lobstein J, Emrich CA, Jeans C, Faulkner M, Riggs P, Berkmen M. SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm. Microb Cell Fact. 2012;11(1):56.
14. Hansen MR, Mueller L, Pardi A. Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions. Nat Struct Biol. 1998;5(12):1065-1074. (Pubitemid 28546270)
15. Ruckert M, Otting G. Alignment of biological macromolecules in novel nonionic liquid crystalline media for NMR experiments. J Am Chem Soc. 2000;122:7793-7797.
16. Pringle SD, Giles K, Wildgoose JL, et al. An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/OA-TOF instrument. Int J Mass Spectrom. 2007;261(1): 1-12.
17. Kay LE, Torchia DA, Bax A. Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease. Biochemistry. 1989; 28(23):8972-8979. (Pubitemid 19283459)
18. Lipari G, Szabo A. Model-free approach to the interpretation of nuclear magnetic-resonance relaxation in macromolecules.1. theory and range of validity. J Am Chem Soc. 1982;104(17): 4546-4559.
19. Vallurupalli P, Hansen DF, Stollar E, Meirovitch E, Kay LE. Measurement of bond vector orientations in invisible excited states of proteins. Proc Natl Acad Sci USA. 2007;104(47):18473-18477. (Pubitemid 350210721)
20. Herrmann T, G̈untert P, Ẅuthrich K. Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA. J Mol Biol. 2002;319(1):209-227. (Pubitemid 34729497)
21. Schwieters C, Kuszewski J, Mariusclore G. Using Xplor-NIH for NMR molecular structure determination. Prog Nucl Magn Reson Spectrosc. 2006;48(1):47-62.
22. Marti T, R̈osselet SJ, Titani K, Walsh KA. Identification of disulfide-bridged substructures within human von Willebrand factor. Biochemistry. 1987;26(25):8099-8109. (Pubitemid 18023058)
23. Mayadas TN, Wagner DD. Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly. Proc Natl Acad Sci USA. 1992;89(8):3531-3535.
24. Casonato A, Pontara E, Zerbinati P, Zucchetto A, Girolami A. The evaluation of factor VIII binding activity of von Willebrand factor by means of an ELISA method: significance and practical implications. Am J Clin Pathol. 1998;109(3): 347-352. (Pubitemid 28110580)
25. Saenko EL, Scandella D. A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor. J Biol Chem. 1995;270(23): 13826-13833.
26. Saenko EL, Loster K, Josic D, Sarafanov AG. Effect of von Willebrand Factor and its proteolytic fragments on kinetics of interaction between the light and heavy chains of human factor VIII. Thromb Res. 1999;96(5):343-354.
27. Dimitrov JD, Christophe OD, Kang J, et al. Thermodynamic analysis of the interaction of factor VIII with von Willebrand factor. Biochemistry. 2012;51(20):4108-4116.
28. Montelione GT, Lyons BA, Emerson SD, Tashiro M. An efficient triple resonance experiment using carbon-13 isotropic mixing for determining sequence-specific resonance assignments of isotopically-enriched proteins. J Am Chem Soc. 1992;114:10974-10975.
29. Grzesiek S, Anglister J, Bax A. Correlation of backbone amide and aliphatic side-chain resonances in 13C/15N enriched proteins by isotropic mixing of 13C magnetization. J Magn Reson B. 1993;101:114-119.
30. 2O samples of proteins. J Magn Reson B. 1993;101: 333-337.
31. Shen Y, Delaglio F, Cornilescu G, Bax A. TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts. J Biomol NMR. 2009;44(4): 213-223.
32. Bax A, Kontaxis G, Tjandra N. Dipolar couplings in macromolecular structure determination. Methods Enzymol. 1997; 2001(339):127-174.
33. Rawlings ND, Tolle DP, Barrett AJ. Evolutionary families of peptidase inhibitors. Biochem J. 2004; 378(Pt 3):705-716. (Pubitemid 38406845)
34. Holm L, Rosenström P. Dali server: conservation mapping in 3D. Nucleic Acids Res. 2010;38(Web Server issue):W545-9.
35. O'Leary JM, Hamilton JM, Deane CM, Valeyev NV, Sandell LJ, Downing AK. Solution structure and dynamics of a prototypical chordin-like cysteine-rich repeat (von Willebrand Factor type C module) from collagen IIA. J Biol Chem. 2004; 279(51):53857-53866. (Pubitemid 40051895)
36. Henzler-Wildman K, Kern D. Dynamic personalities of proteins. Nature. 2007;450(7172): 964-972. (Pubitemid 350273626)
37. Yang D, Mok Y-K, Forman-Kay JD, Farrow NA, Kay LE. Contributions to protein entropy and heat capacity from bond vector motions measured by NMR spin relaxation. J Mol Biol. 1997;272(5): 790-804.
38. Lange OF, Lakomek NA, Farès C, et al. Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science. 2008; 320(5882):1471-1475. (Pubitemid 351929422)
39. Lindorff-Larsen K, Best RB, Depristo MA, Dobson CM, Vendruscolo M. Simultaneous determination of protein structure and dynamics. Nature. 2005; 433(7022):128-132.
40. Hansen DF, Neudecker P, Vallurupalli P, Mulder FAA, Kay LE. Determination of Leu side-chain conformations in excited protein states by NMR relaxation dispersion. J Am Chem Soc. 2010; 132(1):42-43.
41. Hansen DF, Neudecker P, Kay LE. Determination of isoleucine side-chain conformations in ground and excited states of proteins from chemical shifts. J Am Chem Soc. 2010;132(22):7589-7591.
42. Hansen DF, Kay LE. Determining valine sidechain rotamer conformations in proteins from methyl 13C chemical shifts: application to the 360 kDa half-proteasome. J Am Chem Soc. 2011;133(21):8272-8281.
43. Mulder FAA. Leucine side-chain conformation and dynamics in proteins from 13C NMR chemical shifts. ChemBioChem. 2009;10(9):1477-1479.
44. Palmer AG III, Kroenke CD, Loria JP. Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules. Methods Enzymol. 2001;339:204-238. (Pubitemid 32666562)
45. Allen S, Abuzenadah AM, Blagg JL, et al. Two novel type 2N von Willebrand disease-causing mutations that result in defective factor VIII binding, multimerization, and secretion of von Willebrand factor. Blood. 2000;95(6): 2000-2007. (Pubitemid 30151638)
46. Saenko EL, Scandella D. The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor. J Biol Chem. 1997;272(29): 18007-18014. (Pubitemid 27306379)
47. Pontius J, Richelle J, Wodak SJ. Deviations from standard atomic volumes as a quality measure for protein crystal structures. J Mol Biol. 1996;264(1): 121-136. (Pubitemid 26399998)
48. 2. Proc Natl Acad Sci USA. 1973;70(8): 2326-2329.