Thiol oxidation of mitochondrial FO-c subunits: A way to switch off antimicrobial drug targets of the mitochondrial ATP synthase

Medical Hypotheses

Volumn 83, Issue 2, 2014, Pages 160-165

  Nesci, S ^a   Ventrella, V ^a   Trombetti, F ^a   Pirini, M ^a   Pagliarani, A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ENZYME INHIBITOR; MITOCHONDRIAL ATPASE SUBUNIT C; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; THIOL DERIVATIVE; VENTURICIDIN;

BIOLOGICAL MODEL; DRUG DESIGN; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION;

ANTI-INFECTIVE AGENTS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MODELS, BIOLOGICAL; OLIGOMYCINS; OXIDATION-REDUCTION; SULFHYDRYL COMPOUNDS; VENTURICIDINS;

EID: 84903591267     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2014.05.004     Document Type: Article

References (30)

1. Walker J.E. The ATP synthase: the understood, the uncertain and the unknown. Biochem Soc Trans 2013, 41:1-16.
2. Gibbons C., Montgomery M.G., Leslie A.G., Walker J.E. The structure of the central stalk in bovine F(1)-ATPase at 2.4Å resolution. Nat Struct Biol 2000, 7:1055-1061.
3. Dickson V.K., Silvester J.A., Fearnley I.M., Leslie A.G., Walker J.E. On the structure of the stator of the mitochondrial ATP synthase. EMBO J 2006, 25:2911-2918.
4. Lardy H.A., Johnson D., Mcmurray W.C. Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems. Arch Biochem Biophys 1958, 78:587-597.
5. Symersky J., Osowski D., Walters D.E., Mueller D.M. Oligomycin frames a common drug-binding site in the ATP synthase. Proc Natl Acad Sci USA 2012, 109:13961-13965.
6. Watt I.N., Montgomery M.G., Runswick M.J., Leslie A.G., Walker J.E. Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria. Proc Natl Acad Sci USA 2010, 107:16823-16827.
7. Nesci S., Ventrella V., Trombetti F., Pirini M., Pagliarani A. Mussel and mammalian ATP synthase share the same bioenergetic cost of ATP. J Bioenerg Biomembr 2013, 45:289-300.
8. + synthase has an undecameric rotor. EMBO Rep 2001, 2:229-233.
9. Nesci S., Ventrella V., Trombetti F., Pirini M., Pagliarani A. Thiol oxidation is crucial in the desensitization of the mitochondrial F1FO-ATPase to oligomycin and other macrolide antibiotics. Biochim Biophys Acta 2014, 1840:1882-1891. 10.1016/j.bbagen.2014.01.008.
10. +-ATPase by venturicidin, oligomycin and ossamycin. Biochim Biophys Acta 1985, 807:238-244.
11. Huss M., Wieczorek H. Inhibitors of V-ATPases: old and new players. J Exp Biol 2009, 212(Pt 3):341-346.
12. Hong S., Pedersen P.L. ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas. Microbiol Mol Biol Rev 2008, 72:590-641.
13. O-ATPase. Mitochondrion 2013, 13:312-319.
14. Haagsma A.C., Podasca I., Koul A., Andries K., Guillemont J., Lill H., et al. Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase. PLoS One 2011, 6:e23575.
15. Walsh C. Molecular mechanisms that confer antibacterial drug resistance. Nature 2000, 406:775-781.
16. Lu P, Lill H, Bald D. ATP synthase in mycobacteria: special features and implications for a function as drug target. Biochim Biophys Acta, in press. doi: http://dx.doi.org/10.1016/j.bbabio.2014.01.022.
17. Balemans W., Vranckx L., Lounis N., Pop O., Guillemont J., Vergauwen K., et al. Novel antibiotics targeting respiratory ATP synthesis in Gram-positive pathogenic bacteria. Antimicrob Agents Chemother 2012, 56:4131-4139.
18. Ahmad Z., Okafor F., Azim S., Laughlin T.F. ATP synthase: a molecular therapeutic drug target for antimicrobial and antitumor peptides. Curr Med Chem 2013, 20:1956-1973.
19. O ATP Synthase: modulation of the body's powerhouse and its implications for human disease. Curr Med Chem 2011, 18:4684-4714.
20. Fox G.J., Menzies D. A review of the evidence for using bedaquiline (TMC207) to treat multi-drug resistant tuberculosis. Infect Dis Ther 2013, 2:123-144.
21. Nesci S., Ventrella V., Trombetti F., Pirini M., Pagliarani A. Multi-site TBT binding skews the inhibition of oligomycin on the mitochondrial Mg-ATPase in Mytilus galloprovincialis. Biochimie 2011, 93:1157-1164.
22. O-ATPase sensitivity to oligomycin in mussel mitochondria. Appl Organomet Chem 2012, 26:593-599.
23. Nesci S., Ventrella V., Trombetti F., Pirini M., Pagliarani A. Tributyltin-driven enhancement of the DCCD insensitive Mg-ATPase activity in mussel digestive gland mitochondria. Biochimie 2012, 94:727-733.
24. Devenish R.J., Prescott M., Boyle G.M., Nagley P. The oligomycin axis of mitochondrial ATP synthase: OSCP and the proton channel. J Bioenerg Biomembr 2000, 32:507-515.
25. O-ATPase desensitization to oligomycin by tributyltin is due to thiol oxidation. Biochimie 2014, 97:128-137.
26. Nesci S., Ventrella V., Trombetti F., Pirini M., Borgatti A.R., Pagliarani A. Tributyltin (TBT) and dibutyltin (DBT) differently inhibit the mitochondrial Mg-ATPase activity in mussel digestive gland. Toxicol In Vitro 2011, 25:117-124.
27. O-ATPase function by butyltin compounds. Appl Organomet Chem 2013, 27:199-205.
28. Munguia T., Cervantes-Lee F., Parkanyi L., Pannel K.H. Organotin-sulphur intramolecular interactions: an overview of current and past compounds and the biological implications of Sn-S interactions. Modern aspects of main groups chemistry 2006, 422-435. ACS Publications, (chapter 30).
29. Nesci S., Ventrella V., Trombetti F., Pirini M., Pagliarani A. Tributyltin (TBT) and mitochondrial respiration in mussel digestive gland. Toxicol In Vitro 2011, 25:951-959.
30. Boyer P.D. The ATP synthase - a splendid molecular machine. Annu Rev Biochem 1997, 66:717-749.