Oligomycin frames a common drug-binding site in the ATP synthase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 35, 2012, Pages 13961-13965

  Symersky, Jindrich ^a   Osowski, Daniel ^a   Walters, D Eric ^a   Mueller, David M ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

F1Fo ATP synthase; Proton pore

Indexed keywords

CARBOXYL GROUP; GLUTAMINE; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

AMINO ACID SEQUENCE; ANTIBIOTIC THERAPY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG SENSITIVITY; DRUG TARGETING; HYDROGEN BOND; HYDROPHOBICITY; MYCOBACTERIUM TUBERCULOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; YEAST;

ANIMALS; ANTI-BACTERIAL AGENTS; ATP SYNTHETASE COMPLEXES; BACTERIAL PROTON-TRANSLOCATING ATPASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; HYDROGEN BONDING; MITOCHONDRIA; MYCOBACTERIUM TUBERCULOSIS; OLIGOMYCINS; PROTEIN STRUCTURE, SECONDARY; PROTON-TRANSLOCATING ATPASES; PROTONS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VACUOLAR PROTON-TRANSLOCATING ATPASES;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 84865544585     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207912109     Document Type: Article

References (36)

1. Lardy HA, Johnson D, McMurray WC (1958) Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems. Arch Biochem Biophys 78:587-597.
2. Racker E (1963) A mitochondrial factor conferring oligomycin sensitivity on soluble mitochondrial ATPase. Biochem Biophys Res Commun 10:435-439.
3. Racker E (1964) A reconstituted system of oxidative phosphorylation. Biochem Biophys Res Commun 14:75-78.
4. Kagawa Y, Racker E (1966) Partial resolution of the enzymes catalyzing oxidative phosphorylation. 8. Properties of a factor conferring oligomycin sensitivity on mitochondrial adenosine triphosphatase. J Biol Chem 241:2461-2466.
5. Watt IN, Montgomery MG, Runswick MJ, Leslie AG, Walker JE (2010) Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria. Proc Natl Acad Sci USA 107:16823-16827.
6. Stock D, Leslie AGW, Walker JE (1999) Molecular architecture of the rotary motor in ATP synthase. Science 286:1700-1705. (Pubitemid 129515869)
7. Pogoryelov D, et al. (2010) Microscopic rotary mechanism of ion translocation in the F(o) complex of ATP synthases. Nat Chem Biol 6:891-899.
8. Symersky J, et al. (2012) Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation. Nat Struct Mol Biol 19:485-491, S1.
9. Palmer RA, Potter BS (2008) X-ray structures and absolute configurations of the antibiotics oligomycins A, B, and C: Inhibitors of ATP synthase. J Chem Crystallogr 38(4):243-253.
10. Moore WJ (1972) Physical Chemistry (Prentice-Hall, Englewood Cliffs, NJ), pp 913-918.
11. Tanford C (1978) The hydrophobic effect and the organization of living matter. Science 200:1012-1018.
12. Tuñón I, Silla E, Pascual-Ahuir JL (1992) Molecular surface area and hydrophobic effect. Protein Eng 5:715-716.
13. Lee CP, Azzone GF, Ernster L (1964) Evidence for Energy-Coupling in Non-Phosphorylating Electron Transport Particles from Beef-Heart Mitochondria. Nature 201:152-155.
14. Lee CP, Ernster L (1965) Restoration of Oxidative Phosphorylation in Non-Phosphorylating Submitochondrial Particles by Oligomycin. Biochem Biophys Res Commun 18:523-529.
15. Fessenden JM, Racker E (1966) Partial resolution of the enzymes catalyzing oxidative phosphorylation. XI. Stimulation of oxidative phosphorylation by coupling factors and oligomycin; inhibition by an antibody against coupling factor 1. J Biol Chem 241: 2483-2489.
16. Ooi BG, Novitski CE, Nagley P (1985) DNA sequence analysis of the oli1 gene reveals amino acid changes in mitochondrial ATPase subunit 9 from oligomycin-resistant mutants of Saccharomyces cerevisiae. Eur J Biochem 152:709-714. (Pubitemid 16192377)
17. Galanis M, Mattoon JR, Nagley P (1989) Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance. FEBS Lett 249:333-336. (Pubitemid 19143488)
18. Nagley P, Hall RM, Ooi BG (1986) Amino acid substitutions in mitochondrial ATPase subunit 9 of Saccharomyces cerevisiae leading to oligomycin or venturicidin resistance. FEBS Lett 195:159-163. (Pubitemid 16048994)
19. Sebald W, Wachter E, Tzagoloff A (1979) Identification of amino acid substitutions in the dicyclohexylcarbodiimide-binding subunit of the mitochondrial ATPase complex from oligomycin-resistant mutants of Saccharomyces cerevisiae. Eur J Biochem 100:599-607. (Pubitemid 10165901)
20. Griffiths DE, Houghton RL (1974) Studies on energy-linked reactions: Modified mitochondrial ATPase of oligomycin-resistant mutants of Saccharomyces cerevisiae. Eur J Biochem 46:157-167.
21. Perlin DS, Latchney LR, Senior AE (1985) Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin. Biochim Biophys Acta 807:238-244. (Pubitemid 15025852)
22. Hong S, Pedersen PL (2008) ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas. Microbiol Mol Biol Rev 72:590-641.
23. Foury F, Tzagoloff A (1976) Localization on mitochondrial DNA of mutations leading to a loss of rutamycin-sensitive adenosine triphosphatase. Eur J Biochem 68:113-119.
24. John UP, Nagley P (1986) Amino acid substitutions in mitochondrial ATPase subunit 6 of Saccharomyces cerevisiae leading to oligomycin resistance. FEBS Lett 207:79-83. (Pubitemid 17179367)
25. Andries K, et al. (2005) A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307:223-227. (Pubitemid 40116230)
26. Koul A, et al. (2008) Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. J Biol Chem 283:25273-25280.
27. Petrella S, et al. (2006) Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria. Antimicrob Agents Chemother 50:2853-2856. (Pubitemid 44198713)
28. Dröse S, Altendorf K (1997) Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol 200:1-8.
29. Otwinowski Z, Minor W (1997) Processing of X-ray data collected in oscillation mode. Methods Enzymol 276:307-326. (Pubitemid 27085611)
30. Collaborative Computational Project, Number 4 (1994) The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50:760-763.
31. Vagin A, Teplyakov A (2010) Molecular replacement with MOLREP. Acta Crystallogr D Biol Crystallogr 66:22-25.
32. Murshudov GN, Vagin AA, Dodson EJ (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 53:240-255. (Pubitemid 27235885)
33. Emsley P & Cowtan K (2004) Coot: Model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60(Pt 12 Pt 1):2126-2132.
34. Allen FH (2002) The Cambridge Structural Database: A quarter of a million crystal structures and rising. Acta Crystallogr B 58(Pt 3 Pt 1):380-388.
35. Schüttelkopf AW, van Aalten DM (2004) PRODRG: A tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr D Biol Crystallogr 60:1355-1363.
36. Laskowski RA, MacArthur MW, Moss DS, Thorton JM (1993) PROCHECK: A program software suite for macromolecular structure determination. J Appl Cryst 26(Part 2):283-291.