Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort

Pharmacogenetics and Genomics

Volumn 22, Issue 2, 2012, Pages 95-104

  Schierer, Ashley ^a   Been, Latonya F ^a   Ralhan, Sarju ^b   Wander, Gurpreet S ^b   Aston, Christopher E ^a   Sanghera, Dharambir K ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b DAYANAND MEDICAL COLLEGE AND HOSPITAL   (India)

Author keywords

cholesteryl ester transfer protein; coronary artery disease; fasting blood glucose; genome wide association study; homeostasis model assessment for b cell function; homeostasis model assessment for insulin resistance; minor allele frequency; normoglycemic; type 2 diabetes; waist to hip ratio

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGE; AGED; ARTICLE; ASIAN; BODY MASS; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENVIRONMENTAL FACTOR; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEREDITY; HETEROZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; SEX; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

EID: 84855915805     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32834dc9ef     Document Type: Article

References (28)

1. Libby P. The forgotten majority: unfinished business in cardiovascular risk reduction. J Am Coll Cardiol 2005; 46:1225-1228. (Pubitemid 41615541)
2. Hassanzadeh T, Firoozrai M, Zonouz AE, Zavarehee A, Paoli M. Taq1B polymorphism of cholesteryl ester transfer protein (CETP) gene in primary combined hyperlipidaemia. Indian J Med Res 2009; 129:293-298.
3. Snieder H, Van Doornen LJ, Boomsma DI. Dissecting the genetic architecture of lipids, lipoproteins, and apolipoproteins: lessons from twin studies. Arterioscler Thromb Vasc Biol 1999; 19:2826-2834. (Pubitemid 30029806)
4. Yilmaz H, Isbir T, Agachan B, Karaali ZE. Effects of cholesterol ester transfer protein Taq1B gene polymorphism on serum lipoprotein levels in Turkish coronary artery disease patients. Cell Biochem Funct 2005; 23:23-28. (Pubitemid 40065169)
5. Padmaja N, Ravindra Kumar M, Soya SS, Adithan C. Common variants of cholesteryl ester transfer protein gene and their association with lipid parameters in healthy volunteers of Tamilian population. Clin Chim Acta 2007; 375:140-146. (Pubitemid 44584236)
6. Thompson A, Di Angelantonio E, Sarwar N, Erqou S, Saleheen D, Dullaart RP, et al. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA 2008; 299:2777-2788. (Pubitemid 351846853)
7. Bruce C, Sharp DS, Tall AR. Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia. J Lipid Res 1998; 39:1071-1078. (Pubitemid 28222013)
8. Agerholm-Larsen B, Nordestgaard BG, Steffensen R, Jensen G, Tybjaerg-Hansen A. Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene. Circulation 2000; 101:1907-1912. (Pubitemid 30225270)
9. Vasan RS, Pencina MJ, Robins SJ, Zachariah JP, Kaur G, D'Agostino RB, Ordovas JM. Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation 2009; 120:2414-2420.
10. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008; 40:161-169. (Pubitemid 351171403)
11. Hegele RA. Plasma lipoproteins: genetic influences and clinical implications. Nat Rev Genet 2009; 10:109-121.
12. Poss J, Custodis F, Werner C, Weingartner O, Bohm M, Laufs U. Cardiovascular disease and dyslipidemia: beyond LDL. Curr Pharm Des 2011; 17:861-870.
13. Cannon CP, Shah S, Dansky HM, Davidson M, Brinton EA, Gotto AM, et al. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N Engl J Med 2010; 363:2406-2415.
14. Sanghera DK, Bhatti JS, Bhatti GK, Ralhan SK,Wander GS, Singh JR, et al. The Khatri Sikh Diabetes Study (SDS): study design, methodology, sample collection, and initial results. Hum Biol 2006; 78:43-63. (Pubitemid 44087146)
15. Sanghera DK, Been LF, Ralhan S, Wander GS, Mehra NK, Singh JR, et al. Genome-wide linkage scan to identify Loci associated with type 2 diabetes and blood lipid phenotypes in the Sikh Diabetes Study. PLoS One 2011; 6:e21188.
16. Sanghera DK, Demirci FY, Been L, Ortega L, Ralhan S, Wander GS, et al. PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor. Metab Clin Exp 2009; 59:492-501.
17. Sanghera DK, Ortega L, Han S, Singh J, Ralhan SK, Wander GS, et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 2008; 9:59.
18. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004; 27 (Suppl 1):S5-S10.
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-419. (Pubitemid 15018832)
20. Halldorsson BV, Istrail S, De La Vega FM. Optimal selection of SNP markers for disease association studies. Hum Hered 2004; 58:190-202. (Pubitemid 40754351)
21. Purcell SCS, Sham PC. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003; 19:149-150. (Pubitemid 36150192)
22. Freeman DJ, Griffin BA, Holmes AP, Lindsay GM, Gaffney D, Packard CJ, Shepherd J. Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors. Associations between the TaqI B RFLP in the CETP gene and smoking and obesity. Arterioscler Thromb 1994; 14:336-344.
23. Bamshad M, Kivisild T, Watkins WS, Dixon ME, Ricker CE, Rao BB, et al. Genetic evidence on the origins of Indian caste populations. Genome Res 2001; 11:994-1004. (Pubitemid 32834545)
24. Pascot A, Lemieux I, Bergeron J, Tremblay A, Nadeau A, Prud'homme D, et al. HDL particle size: a marker of the gender difference in the metabolic risk profile. Atherosclerosis 2002; 160:399-406. (Pubitemid 34159334)
25. Rossouw JE. Hormones, genetic factors, and gender differences in cardiovascular disease. Cardiovasc Res 2002; 53:550-557. (Pubitemid 34175247)
26. Sandhofer A, Tatarczyk T, Laimer M, Ritsch A, Kaser S, Paulweber B, et al. The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome. Obesity (Silver Spring) 2008; 16:919-922. (Pubitemid 351465656)
27. McTaggart F, Jones P. Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit. Cardiovasc Drugs Ther 2008; 22:321-338.
28. Clarke AJ, Cooper DN. GWAS: heritability missing in action? Eur J Hum Genet 2010; 18:859-861.