Clinical expression of lymphocytic duodenosis in "mild enteropathy" celiac disease and in functional gastrointestinal syndromes

Scandinavian Journal of Gastroenterology

Volumn 49, Issue 7, 2014, Pages 794-800

  Zanini, Barbara ^a   Lanzarotto, Francesco ^a   Villanacci, Vincenzo ^b   Carabellese, Nice ^b   Ricci, Chiara ^a   Lanzini, Alberto ^a  

^a Gastroenterology Unit Spedali Civili   (Italy)

^b SPEDALI CIVILI   (Italy)

Author keywords

Celiac disease; Clinical presentation; Duodenal histology; Functional gastrointestinal syndromes; Microscopic enteritis; Mild enteropathy

Indexed keywords

ADULT; ARTICLE; CELIAC DISEASE; CLINICAL FEATURE; DIARRHEA; DIGESTIVE SYSTEM FUNCTION DISORDER; DUODENUM; DYSPEPSIA; ENTEROPATHY; FEMALE; GASTROINTESTINAL SYMPTOM; HELICOBACTER INFECTION; HISTOLOGY; HUMAN; HUMAN TISSUE; IRRITABLE COLON; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; PAIN; PREVALENCE; PRIORITY JOURNAL; SYNDROME; COMPLICATION; DUODENAL DISEASES; HELICOBACTER INFECTIONS; IRRITABLE BOWEL SYNDROME; LYMPHOCYTOSIS; MIDDLE AGED; PATHOLOGY; PHENOTYPE; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX;

ADULT; CELIAC DISEASE; DIARRHEA; DUODENAL DISEASES; DYSPEPSIA; FEMALE; HELICOBACTER INFECTIONS; HUMANS; IRRITABLE BOWEL SYNDROME; LYMPHOCYTOSIS; MALE; MIDDLE AGED; PHENOTYPE; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 84903587984     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2014.919017     Document Type: Article

References (38)

1. Bizzaro N, Tozzoli R, Villalta D, Fabris M, Tonutti E. Cutting-edge issues in celiac disease and in gluten intolerance. Clin Rev Allergy Immunol 2012;42:279-87
2. Troncone R, Jabri B. Coeliac disease and gluten sensitivity. J Intern Med 2011;269:582-90
3. Kakar S, Nehra V, Murray JA, Dayharsh GA, Burgart LJ. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol 2003;98:2027-33
4. Memeo L, Jhang J, Hibshoosh H, Green PH, Rotterdam H, Bhagat G. Duodenal intraepithelial lymphocytosis with normal villous architecture: Common occurrence in H. pylori gastritis. Mod Pathol 2005;18:1134-44
5. Vande Voort JL, Murray JA, Lahr BD, Van Dyke CT, Kroning CM, Moore SB, et al. Lymphocytic duodenosis and the spectrum of celiac disease. Am J Gastroenterol 2009;104:142-8
6. Kurppa K, Collin P, Viljamaa M, Haimila K, Saavalainen P, Partanen J, et al. Diagnosing mild enteropathy celiac disease: A randomized, controlled clinical study. Gastroenterology 2009;136:816-23
7. Walker MM, Talley NJ, Prabhakar M, Pennaneac'h CJ, Aro P, Ronkainen J, et al. Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther 2009;29:765-73
8. Aziz I, Evans KE, Hopper AD, Smillie DM, Sanders DS. A prospective study into the aetiology of lymphocytic duodenosis. Aliment Pharmacol Ther 2010;32:1392-7
9. Farrell RJ, Kelly CP. Diagnosis of celiac sprue. Am J Gastroenterol 2001;96:3237-46
10. Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: The "no man's land" of gluten sensitivity. Am J Gastroenterol 2009;104:1587-94
11. Kaukinen K, Maki M, Partanen J, Sievanen H, Collin P. Celiac disease without villous atrophy: Revision of criteria called for. Dig Dis Sci 2001;46:879-87
12. Kurppa K, Collin P, Sievanen H, Huhtala H, Maki M, Kaukinen K. Gastrointestinal symptoms, quality of life and bone mineral density in mild enteropathic coeliac disease: A prospective clinical trial. Scand J Gastroenterol 2010;45: 305-14
13. Zanini B, Caselani F, Magni A, Turini D, Ferraresi A, Lanzarotto F, et al. Celiac disease with mild enteropathy is not mild disease. Clin Gastroenterol Hepatol 2013;11:253-8
14. Barbara G, De GR, Stanghellini V, Cremon C, Salvioli B, Corinaldesi R. New pathophysiological mechanisms in irritable bowel syndrome. Aliment Pharmacol Ther 2004; 20:1-9
15. Barbara G, Wang B, Stanghellini V, De GR, Cremon C, Di NG, et al. Mast cell-dependent excitation of visceralnociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 2007;132:26-37
16. Kunisawa J, Takahashi I, Kiyono H. Intraepithelial lymphocytes: Their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev 2007;215: 136-53
17. Remes-Troche JM, Adames K, Castillo-Rodal AI, Ramirez T, Barreto-Zuniga R, Lopez-Vidal Y, et al. Intraepithelial gammadelta+ lymphocytes: A comparative study between celiac disease, small intestinal bacterial overgrowth, and irritable bowel syndrome. J Clin Gastroenterol 2007;41: 671-6
18. Gargala G, Lecleire S, Francois A, Jacquot S, Dechelotte P, Ballet JJ, et al. Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia. World J Gastroenterol 2007;13:2333-8
19. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992;102:330-54
20. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: An evolving spectrum. Gastroenterology 2001;120:636-51
21. Lanzini A, Lanzarotto F, Villanacci V, Mora A, Bertolazzi S, Turini D, et al. Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet. Aliment Pharmacol Ther 2009;29:1299-308
22. Hayat M, Cairns A, Dixon MF, O'Mahony S. Quantitation of intraepithelial lymphocytes in human Duodenum: What is normal?. J Clin Pathol 2002;55:393-4
23. Monsuur AJ, Wijmenga C. Understanding the molecular basis of celiac disease: What genetic studies reveal. Ann Med 2006;38:578-91
24. Mazzarella G, Maglio M, Paparo F, Nardone G, Stefanile R, Greco L, et al. An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLADQ8 negative coeliac patients. Gut 2003;52:57-62
25. Wahnschaffe U, Ullrich R, Riecken EO, Schulzke JD. Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology 2001;121: 1329-38
26. Wahnschaffe U, Schulzke JD, Zeitz M, Ullrich R. Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2007;5:844-50
27. Volta U, Tovoli F, Cicola R, Parisi C, Fabbri A, Piscaglia M, et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol 2012; 46:680-5
28. Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, De RM, et al. Divergence of gut permeability and mucosal immune gene expression in two glutenassociated conditions: Celiac disease and gluten sensitivity. BMC Med 2011;9:23
29. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, et al. Spectrum of gluten-related disorders: Consensus on new nomenclature and classification. BMC Med 2012;10:13
30. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, et al. The Oslo definitions for coeliac disease and related terms. Gut 2013;62:43-52
31. Carroccio A, Mansueto P, Iacono G, Soresi M, D'Alcamo A, Cavataio F, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: Exploring a new clinical entity. Am J Gastroenterol 2012;107:1898-906; quiz 1907
32. Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 2006;131:1981-2002
33. Rosinach M, Esteve M, Gonzalez C, Temino R, Marine M, Monzon H, et al. Lymphocytic duodenosis: Aetiology and long-Term response to specific treatment. Dig Liver Dis 2012; 44:643-8
34. Barbara G, De GR, Stanghellini V, Cremon C, Corinaldesi R. A role for inflammation in irritable bowel syndrome?. Gut 2002;51:i41-4
35. Barbara G, Stanghellini V, De GR, Cremon C, Cottrell GS, Santini D, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004;126:693-702
36. Chadwick VS, Chen W, Shu D, Paulus B, Bethwaite P, Tie A, et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002;122: 1778-83
37. Evans KE, Aziz I, Cross SS, Sahota GR, Hopper AD, Hadjivassiliou M, et al. A prospective study of duodenal bulb biopsy in newly diagnosed and established adult celiac disease. Am J Gastroenterol 2011;106:1837-742
38. Walker MM, Murray JA, Ronkainen J, Aro P, Storskrubb T, D'Amato M, et al. Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 2010;139: 112-19.