Genetically engineered silk-collagen-like copolymer for biomedical applications: Production, characterization and evaluation of cellular response

Acta Biomaterialia

Volumn 10, Issue 8, 2014, Pages 3620-3629

  Włodarczyk Biegun, Małgorzata K ^a   Werten, Marc W T ^a   De Wolf, Frits A ^a   Van Den Beucken, Jeroen J J P ^b   Leeuwenburgh, Sander C G ^b   Kamperman, Marleen ^a   Cohen Stuart, Martien A ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cellular response; Genetically engineered protein polymers; Hydrogels; Pichia pastoris; Silk collagen like block copolymers

Indexed keywords

AMINO ACIDS; BIOMECHANICS; BLOCK COPOLYMERS; CELL CULTURE; COLLAGEN; GENETIC ENGINEERING; MEDICAL APPLICATIONS; RECOMBINANT PROTEINS; SILK; YEAST;

BIOMEDICAL APPLICATIONS; BLOCK CO POLYMERS; CELLULAR RESPONSE; GENETICALLY ENGINEERED PROTEIN; GENETICALLY ENGINEERED PROTEIN POLYMER; MULTI-FUNCTIONAL MATERIALS; PICHIA PASTORIS; PROTEIN POLYMERS; SILK-COLLAGEN-LIKE BLOCK COPOLYMER; STRUCTURES AND PROPERTIES;

HYDROGELS;

ALKALINE PHOSPHATASE; CALCIUM; COLLAGEN; COPOLYMER; GENETICALLY ENGINEERED PROTEIN POLYMER; HISTIDINE; RECOMBINANT PROTEIN; SILK; UNCLASSIFIED DRUG; BIOMATERIAL; HYDROGEL;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BIOMECHANICS; BIOREACTOR; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLOW KINETICS; HYDROGEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; MINERALIZATION; NONHUMAN; PH; PICHIA PASTORIS; PRIORITY JOURNAL; SUPRAMOLECULAR CHEMISTRY; TISSUE ENGINEERING; ANIMAL; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; GENETICS; MATERIALS TESTING; METABOLISM; PHYSIOLOGY; PICHIA; PROCEDURES; PROTEIN ENGINEERING; RAT; SOLUBILITY;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE MARROW CELLS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN; HYDROGELS; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; PICHIA; PROTEIN ENGINEERING; RATS; RECOMBINANT PROTEINS; SILK; SOLUBILITY;

EID: 84903555006     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.05.006     Document Type: Article

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