The effect of gabapentin versus intrathecal fentanyl on postoperative pain and morphine consumption in cesarean delivery: A prospective, randomized, double-blind study

Archives of Gynecology and Obstetrics

Volumn 290, Issue 1, 2014, Pages 47-52

  Najafi Anaraki, Abdolreza ^a   Mirzaei, Kamran ^a  

^a BUSHEHR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cesarean section; Gabapentin; Intrathecal fentanyl; Pain; Postoperative

Indexed keywords

ANALGESIC AGENT; BUPIVACAINE; FENTANYL; GABAPENTIN; GAPTINE; MORPHINE; UNCLASSIFIED DRUG;

ADULT; APGAR SCORE; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CASE STUDY; CESAREAN SECTION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEADACHE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; NEUROLOGICAL COMPLICATION; NEWBORN; PATIENT SATISFACTION; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIMIPARA; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; RISK REDUCTION; SEDATION; SHIVERING; VISUAL ANALOG SCALE; VOMITING;

ADULT; AMINES; ANALGESICS; ANESTHETICS, INTRAVENOUS; ANESTHETICS, LOCAL; BUPIVACAINE; CESAREAN SECTION; CROSS-SECTIONAL STUDIES; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; FEMALE; FENTANYL; GAMMA-AMINOBUTYRIC ACID; HUMANS; INFANT, NEWBORN; MORPHINE; OUTCOME ASSESSMENT (HEALTH CARE); PAIN, POSTOPERATIVE; PREGNANCY; PROSPECTIVE STUDIES;

EID: 84903553930     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-014-3152-5     Document Type: Article

References (19)

1. Eltzschig HK, Lieberman ES, Camann WR (2003) Regional anesthesia and analgesia for labor and delivery. N Engl J Med 23(348):319-332 (Pubitemid 36119988)
2. Halpern SH, Walsh VL (2001) Multimodal therapy for post-cesarean delivery pain. Reg Anesth Pain Med 26:298-300 (Pubitemid 32667223)
3. Miovech SM, Knapp H, Borucki L, Roncoli M, Arnold L, Brooten D (1994) Major concerns of women after cesarean delivery. J Obstet Gynecol Neonatal Nurs 23:53-59
4. Fukushima S, Takenami T, Yagishita S, Nara Y, Hoka S, Okamoto H (2011) Neurotoxicity of intrathecally administered fentanyl in a rat spinal model. Pain Med 12:717-725. doi:10.1111/j.1526-4637.2011.01084.x
5. Etches R, Sandler A, Daley M (1989) Respiratory depression and spinal opioids. Can J Anaesth 36:165-185 (Pubitemid 19110401)
6. Chaney M (1995) Side effects of intrathecal and epidural opioids. Can J Anaesth 42:891-903
7. Rorarius MG, Mennander S, Suominen P, Rintala S, Puura A, Pirhonen R, Salmelin R, Haanpää M, Kujansuu E, Yli-Hankala A (2004) Gabapentin for the prevention of postoperative pain after vaginal hysterectomy. Pain 110:175-181 (Pubitemid 38953281)
8. Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G (2000) Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg 91:185-191 (Pubitemid 30437084)
9. Montouris G (2003) Gabapentin exposure in human pregnancy: results from the gabapentin pregnancy registry. Epilepsy Behav 4:310-317
10. Ohman I, Vitols S, Tomson T (2005) Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy? Epilepsia 46:1621-1624 (Pubitemid 44921936)
11. Kainu JP, Sarvela J, Tiippana E, Halmesmäki E, Korttila KT (2010) Persistent pain after caesarean section and vaginal birth: a cohort study. Int J Obstet Anesth 19:4-9. doi:10.1016/j.ijoa.2009.03.013
12. Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA, Tesoro EP, Elswick RK (2002) The Richmond agitation-sedation scale. Am J Respir Crit Care Med 15(166):1338-1344
13. Wilson E, David A, MacKenzie N, Grant IS (1990) Sedation during spinal anaesthesia: comparison of propofol and midazolam. Br J Anaesth 64:48-52 (Pubitemid 20035242)
14. Christensen M, Thomson V, Letson GW (2008) Evaluating the reach of universal newborn hearing screening in Colorado. Am J Prev Med 35(6):594-597. doi:10.1016/j.amepre.2008.09.007
15. Dahlgren G, Hultstrand C, Jakobsson J, Norman M, Eriksson EW, Martin H (1997) Intrathecal sufentanil, fentanyl, or placebo added to bupivacaine for cesarean section. Anesth Analg 85:1288-1293 (Pubitemid 28130527)
16. Moore A, Costello J, Wieczorek P, Shah V, Taddio A, Carvalho JCA (2011) Gabapentin improves postcesarean delivery pain management: a randomized, placebo-controlled trial. Anesth Analg 112:167-173. doi:10.1213/ANE. 0b013e3181fdf5ee
17. Ajori L, Nazari L, Mazloomfard MM, Amiri Z (2012) Effects of gabapentin on postoperative pain, nausea and vomiting after abdominal hysterectomy: a double blind randomized clinical trial. Arch Gynecol Obstet 285:677-682. doi:10.1007/s00404-011-2023-6
18. Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB (2002) A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 97:560-564 (Pubitemid 34977313)
19. Short J, Downey K, Bernstein P, Shah V, Carvalho JC (2012) A single preoperative dose of gabapentin does not improve postcesarean delivery pain management: a randomized, double-blind, placebo-controlled dose-finding trial. Anesth Analg 115:1336-1342. doi:10.1213/ANE.0b013e31826ac3b9