Estradiol increases mucus synthesis in bronchial epithelial cells

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Tam, Anthony ^a   Wadsworth, Samuel ^a   Dorscheid, Delbert ^a   Man, Shu Fan Paul ^a   Sin, Don D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR BETA; MESSENGER RNA; MUCIN 5AC; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; FUCOSYLTRANSFERASE; MUC5AC PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; BRONCHUS MUCOSA; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FUT 4 GENE; FUT 5 GENE; FUT 6 GENE; GENE; GENE EXPRESSION; HORMONE ACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MUCIN 5AC GENE; MUCUS SECRETION; PROTEIN EXPRESSION; PROTEIN PROCESSING; APOPTOSIS; BRONCHUS; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; GOBLET CELL; METABOLISM; MIDDLE AGED; MUCUS; PERIODIC ACID SCHIFF STAIN; YOUNG ADULT;

ADOLESCENT; ADULT; APOPTOSIS; BRONCHI; CELL COUNT; CELL PROLIFERATION; EPITHELIAL CELLS; ESTRADIOL; ESTROGEN RECEPTOR BETA; FEMALE; FUCOSYLTRANSFERASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GOBLET CELLS; HUMANS; MIDDLE AGED; MUCIN 5AC; MUCUS; NFATC TRANSCRIPTION FACTORS; PERIODIC ACID-SCHIFF REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 84903542975     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100633     Document Type: Article

References (25)

1. Farha S, Asosingh K, Laskowski D, Hammel J, Dweik RA, et al. (2009) Effects of the menstrual cycle on lung function variables in women with asthma. Am J Respir Crit Care Med 180: 304-310.
2. Johannesson M, Ludviksdottir D, Janson C (2000) Lung function changes in relation to menstrual cycle in females with cystic fibrosis. Respir Med 94: 1043-1046.
3. Hogg JC, Chu FS, Tan WC, Sin DD, Patel SA, et al. (2007) Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology. Am J Respir Crit Care Med 176: 454-459. (Pubitemid 47358099)
4. Sheehan JK, Kirkham S, Howard M, Woodman P, Kutay S, et al. (2004) Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem 279: 15698-15705. (Pubitemid 38618972)
5. Hovenberg HW, Davies JR, Carlstedt I (1996) Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells. Biochem J 318 (Pt 1): 319-324. (Pubitemid 26283662)
6. Wickstrom C, Davies JR, Eriksen GV, Veerman EC, Carlstedt I (1998) MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J 334 (Pt 3): 685-693. (Pubitemid 28457218)
7. Thornton DJ, Rousseau K, McGuckin MA (2008) Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 70: 459-486. (Pubitemid 351738188)
8. Smirnova MG, Guo L, Birchall JP, Pearson JP (2003) LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells. Cell Immunol 221: 42-49. (Pubitemid 36555393)
9. Yoon JH, Kim KS, Kim HU, Linton JA, Lee JG (1999) Effects of TNF-alpha and IL-1 beta on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells. Acta Otolaryngol 119: 905-910. (Pubitemid 30126643)
10. Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, et al. (2003) Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/ autocrine loop. J Biol Chem 278: 17036-17043. (Pubitemid 36799579)
11. Danahay H, Atherton H, Jones G, Bridges RJ, Poll CT (2002) Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 282: L226-236. (Pubitemid 34654674)
12. Voynow JA, Young LR, Wang Y, Horger T, Rose MC, et al. (1999) Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 276: L835-843. (Pubitemid 29249637)
13. Takeyama K, Dabbagh K, Lee HM, Agusti C, Lausier JA, et al. (1999) Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A 96: 3081-3086. (Pubitemid 29148847)
14. Shao MX, Nakanaga T, Nadel JA (2004) Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol 287: L420-427. (Pubitemid 38943925)
15. Kohri K, Ueki IF, Shim JJ, Burgel PR, Oh YM, et al. (2002) Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor. Eur Respir J 20: 1263-1270. (Pubitemid 35331887)
16. Dougherty SM, Mazhawidza W, Bohn AR, Robinson KA, Mattingly KA, et al. (2006) Gender difference in the activity but not expression of estrogen receptors alpha and beta in human lung adenocarcinoma cells. Endocr Relat Cancer 13: 113-134.
17. Voynow JA, Rubin BK (2009) Mucins, mucus, and sputum. Chest 135: 505-512.
18. Gruenert DC, Basbaum CB, Welsh MJ, Li M, Finkbeiner WE, et al. (1988) Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proc Natl Acad Sci U S A 85: 5951-5955.
19. Lamblin G, Degroote S, Perini JM, Delmotte P, Scharfman A, et al. (2001) Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis. Glycoconj J 18: 661-684. (Pubitemid 35402107)
20. Dave V, Childs T, Xu Y, Ikegami M, Besnard V, et al. (2006) Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest 116: 2597-2609. (Pubitemid 44511624)
21. Dave V, Childs T, Whitsett JA (2004) Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells. J Biol Chem 279: 34578-34588. (Pubitemid 39318087)
22. Smith PL, Myers JT, Rogers CE, Zhou L, Petryniak B, et al. (2002) Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. J Cell Biol 158: 801-815. (Pubitemid 34920117)
23. Becker DJ, Lowe JB (2003) Fucose: biosynthesis and biological function in mammals. Glycobiology 13: 41R-53R. (Pubitemid 36850123)
24. Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, et al. (2004) Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity. J Med Chem 47: 5872-5893. (Pubitemid 39507333)
25. Sun J, Huang YR, Harrington WR, Sheng S, Katzenellenbogen JA, et al. (2002) Antagonists selective for estrogen receptor alpha. Endocrinology 143: 941-947. (Pubitemid 34168188)