Altered autophagy induction by sera from pregnant women with pre-eclampsia: A case-control study

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 121, Issue 8, 2014, Pages 958-964

  Kanninen, T T ^a   Jayaram, A ^a   Jaffe Lifshitz, S ^a   Witkin, S S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Autophagy; endoglin; p62; pre eclampsia; pregnancy; transforming growth factor 1

Indexed keywords

ENDOGLIN; INTERLEUKIN 13; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1;

ADOLESCENT; ADULT; ARTICLE; AUTOPHAGY; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PREECLAMPSIA; PREGNANT WOMAN; PRIORITY JOURNAL; SERUM;

AUTOPHAGY; ENDOGLIN; P62; PRE-ECLAMPSIA; PREGNANCY; TRANSFORMING GROWTH FACTOR Β1;

ADOLESCENT; ADULT; ANTIGENS, CD; AUTOPHAGY; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GESTATIONAL AGE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-13; LEUKOCYTES, MONONUCLEAR; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, CELL SURFACE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84903540488     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/1471-0528.12755     Document Type: Article

References (22)

1. Mizushima N,. Physiological functions of autophagy. Curr Top Microbiol Immunol 2009; 335: 71-84.
2. Roberts JM, Redman CWG,. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 1993; 341: 1447-51.
3. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R,. Preeclampsia. Lancet 2010; 376: 631-44.
4. Oh SY, Choi SJ, Kim KH, Cho EY, Kim JH, Roh CR,. Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod Sci 2008; 15: 912-20.
5. Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, et al. Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnancy period, is involved in poor placentation in preeclampsia. Autophagy 2013; 9: 303-16.
6. Kanninen TT, de Andrade Ramos BR, Jaffe S, Bongiovanni AM, Linhares IM, Di Renzo GC, et al. Inhibition of Autophagy by Sera From Pregnant Women. Reprod Sci 2013; 20: 1327-31.
7. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002.ACOG Committee on Practice Bulletins-Obstetrics. Obstet Gynecol 2002; 99: 159-67.
8. Massey DO, Bredin F, Parkes M,. Use of sirolimus (rapamycin) to treat refractory Crohn's disease. Gut 2008; 57: 1294-6.
9. Levine B, Mizushima N, Virgin HW,. Autophagy in immunity and inflammation. Nature 2011; 469: 323-35.
10. Kuballa P, Nolte WM, Castoreno AB, Xavier RJ,. Autophagy and the immune system. Annu Rev Immunol 2012; 30: 611-46.
11. Redman CW, Sargent IL,. Preeclampsia, the placenta and the maternal systemic inflammatory response-a review. Placenta 2003; 24 (suppl A): S21-7.
12. Giorgi VS, Peracoli MT, Peracoli JC, Witkin SS, Bannwart-Castro CF,. Silibinin modulates the NF-κB pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. J Reprod Immunol 2012; 95: 67-72.
13. Borzychowski AM, Sargent IL, Redman CW,. Inflammation and pre-eclampsia. Semin Fetal Neonatal Med 2006; 11: 309-16.
14. Roberts JM, Bell MJ,. If we know so much about preeclampsia, why haven't we cured the disease? J Reprod Immunol 2013; 99: 1-9.
15. Hirota Y, Cha J, Yoshie M, Daikoku T, Dey SK,. Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice. Proc Natl Acad Sci USA 2011; 108: 10873-8.
16. Signorelli P, Avagliano L, Virgili E, Gagliostro V, Doi P, Braidotti P, et al. Autophagy in term normal human placentas. Placenta 2011; 32: 482-5.
17. Doulaveris G, Orfanelli T, Benn K, Zervoudakis I, Skupski D, Witkin SS,. A polymorphism in an autophagy-related gene, ATG16L1, influences time to delivery in women with an unfavorable cervix who require labor induction. J Perinat Med 2013; 41: 411-14.
18. Ghadimi D, de Vrese M, Heller KJ, Schrezenmeir J,. Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1-autophagy-promoting cytokine (IFN-γ) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. Int Immunopharmacol 2010; 10: 694-706.
19. Sobolewska A, Gajewska M, Zarzynska J, Gajkowska B, Motyl J,. IGF-1, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathway. Eur J Cell Biol 2009; 88: 117-30.
20. Bainbridge SA, Roberts JM,. Uric acid as a pathogenic factor in preeclampsia. Placenta 2008; 29 (Suppl A): S67-72.
21. Hahn S, Holzgreve W,. Fetal cells and cell-free fetal DNA in maternal blood: new insights into pre-eclampsia. Hum Reprod Update 2002; 8: 501-8.
22. Redman CW, Tannetta DS, Dragovic RA, Gandiner C, Southcomb JH, Sargent IL,. Review: does size matter? Placental debris and the pathophysiology of pre-eclampsia. Placenta 2012; 33 (Suppl): S48-54.