Pathways linking regional hyperintensities in the brain and slower gait

NeuroImage

Volumn 99, Issue , 2014, Pages 7-13

  Bolandzadeh, Niousha ^a,b   Liu Ambrose, Teresa ^a,b   Aizenstein, Howard ^c   Harris, Tamara ^d   Launer, Lenore ^d   Yaffe, Kristine ^e   Kritchevsky, Stephen B ^f   Newman, Anne ^g   Rosano, Caterina ^g  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f WAKE FOREST SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Cognitive function; Executive function; Gait speed; Mediation; Mobility; White matter hyperintensities

Indexed keywords

AGED; ARTICLE; BRAIN HYPERINTENSITY; COMPARATIVE STUDY; CORPUS CALLOSUM; CROSS-SECTIONAL STUDY; EXECUTIVE FUNCTION; FEMALE; HUMAN; HUMAN EXPERIMENT; INFORMATION PROCESSING; MALE; NEUROIMAGING; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; WALKING SPEED; WHITE MATTER; AGING; BODY MASS; BRAIN; CHRONIC PAIN; COGNITION; EDUCATIONAL STATUS; GAIT; HYPERTENSION; NERVE TRACT; NEUROLOGIC GAIT DISORDER; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BODY MASS INDEX; BRAIN; CHRONIC PAIN; COGNITION; CROSS-SECTIONAL STUDIES; EDUCATIONAL STATUS; FEMALE; GAIT; GAIT DISORDERS, NEUROLOGIC; HUMANS; HYPERTENSION; MALE; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; WHITE MATTER;

EID: 84903532454     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2014.05.017     Document Type: Article

References (47)

1. Abellan van Kan G., Rolland Y., Andrieu S., et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J. Nutr. Health Aging 2009, 13(10):881-889. (Dec).
2. Annweiler C., Montero-Odasso M. Vascular burden as a substrate for higher-level gait disorders in older adults. A review of brain mapping literature. Panminerva Med. 2012, 54(3):189-204. (Sep).
3. Ball K., Berch D.B., Helmers K.F., et al. Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA 2002, 288(18):2271-2281. (Nov 13).
4. Bolandzadeh N., Davis J.C., Tam R., Handy T.C., Liu-Ambrose T. The association between cognitive function and white matter lesion location in older adults: a systematic review. BMC Neurol. 2012, 12:126.
5. Breteler M.M., van Swieten J.C., Bots M.L., et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994, 44(7):1246-1252. (Jul).
6. Buckalew N., Haut M.W., Aizenstein H., et al. White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?. PM R 2013, 5(6):471-480. (Jun, quiz 480).
7. Colcombe S., Kramer A.F. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol. Sci. 2003, 14(2):125-130. (Mar).
8. Cyarto E.V., Lautenschlager N.T., Desmond P.M., et al. Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial. BMC Psychiatry 2012, 12:167.
9. de Laat K.F., Tuladhar A.M., van Norden A.G., Norris D.G., Zwiers M.P., de Leeuw F.E. Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. Brain 2011, 134(Pt 1):73-83. (Jan).
10. Duering M., Zieren N., Herve D., et al. Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL. Brain 2011, 134(Pt 8):2366-2375. (Aug).
11. Filley C.M. The behavioral neurology of cerebral white matter. Neurology 1998, 50(6):1535-1540. (Jun).
12. Frisoni G.B., Galluzzi S., Pantoni L., Filippi M. The effect of white matter lesions on cognition in the elderly-small but detectable. Nat. Clin. Pract. Neurol. 2007, 3(11):620-627. (Nov).
13. Galluzzi S., Lanni C., Pantoni L., Filippi M., Frisoni G.B. White matter lesions in the elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve. J. Neurol. Sci. 2008, 273(1-2):3-9. (Oct 15).
14. Gunning-Dixon F.M., Raz N. The cognitive correlates of white matter abnormalities in normal aging: a quantitative review. Neuropsychology 2000, 14(2):224-232. (Apr).
15. Guttmann C.R., Benson R., Warfield S.K., et al. White matter abnormalities in mobility-impaired older persons. Neurology 2000, 54(6):1277-1283. (Mar 28).
16. Hayes A. PROCESS: a versatile computational tool for observed variable mediation, moderation, and conditional process modeling (Accessed 10/02/2013). http://www.afhayes.com/public/process2012.pdf.
17. Hua K., Zhang J., Wakana S., et al. Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification. Neuroimage 2008, 39(1):336-347. (Jan 1).
18. Jokinen H., Ryberg C., Kalska H., et al. Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study. J. Neurol. Neurosurg. Psychiatry 2007, 78(5):491-496. (May).
19. Jokinen H., Frederiksen K.S., Garde E., et al. Callosal tissue loss parallels subtle decline in psychomotor speed. A longitudinal quantitative MRI study. The LADIS Study. Neuropsychologia 2012, 50(7):1650-1655. (Jun).
20. Kuo H.K., Lipsitz L.A. Cerebral white matter changes and geriatric syndromes: is there a link?. J. Gerontol. A: Biol. Med. Sci. 2004, 59(8):818-826. (Aug).
21. Lezak M.D. Neuropsychological Assessment 1995, Oxford University Press, New York. 3rd ed.
22. Lindgren A., Roijer A., Rudling O., et al. Cerebral lesions on magnetic resonance imaging, heart disease, and vascular risk factors in subjects without stroke. A population-based study. Stroke 1994, 25(5):929-934. (May).
23. Liu-Ambrose T., Nagamatsu L.S., Graf P., Beattie B.L., Ashe M.C., Handy T.C. Resistance training and executive functions: a 12-month randomized controlled trial. Arch. Intern. Med. 2010, 170(2):170-178. (Jan 25).
24. Malouin F., Richards C.L., Jackson P.L., Dumas F., Doyon J. Brain activations during motor imagery of locomotor-related tasks: a PET study. Hum. Brain Mapp. 2003, 19(1):47-62. (May).
25. Nagamatsu L.S., Handy T.C., Hsu C.L., Voss M., Liu-Ambrose T. Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. Arch. Intern. Med. 2012, 172(8):666-668. (Apr 23).
26. Odenheimer G., Funkenstein H.H., Beckett L., et al. Comparison of neurologic changes in 'successfully aging' persons vs the total aging population. Arch. Neurol. 1994, 51(6):573-580. (Jun).
27. Rosano C., Simonsick E.M., Harris T.B., et al. Association between physical and cognitive function in healthy elderly: the health, aging and body composition study. Neuroepidemiology 2005, 24(1-2):8-14.
28. Rosano C., Kuller L.H., Chung H., Arnold A.M., Longstreth W.T., Newman A.B. Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults. J. Am. Geriatr. Soc. 2005, 53(4):649-654. (Apr).
29. Rosano C., Sigurdsson S., Siggeirsdottir K., et al. Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women. Neurobiol. Aging 2010, 31(7):1197-1204. (Jul).
30. Rosano C., Longstreth W.T., Boudreau R., et al. High blood pressure accelerates gait slowing in well-functioning older adults over 18-years of follow-up. J. Am. Geriatr. Soc. 2011, 59(3):390-397. (Mar).
31. Soumare A., Elbaz A., Zhu Y., et al. White matter lesions volume and motor performances in the elderly. Ann. Neurol. 2009, 65(6):706-715. (Jun).
32. Srikanth V., Phan T.G., Chen J., Beare R., Stapleton J.M., Reutens D.C. The location of white matter lesions and gait-a voxel-based study. Ann. Neurol. 2010, 67(2):265-269. (Feb).
33. Starr J.M., Leaper S.A., Murray A.D., et al. Brain white matter lesions detected by magnetic resonance [correction of resosnance] imaging are associated with balance and gait speed. J. Neurol. Neurosurg. Psychiatry 2003, 74(1):94-98. (Jan).
34. Studenski S., Perera S., Patel K., et al. Gait speed and survival in older adults. JAMA 2011, 305(1):50-58. (Jan 5).
35. Teng E.L., Chui H.C. The Modified Mini-Mental State (3MS) examination. J. Clin. Psychiatry 1987, 48(8):314-318. (Aug).
36. Verghese J., Mahoney J., Ambrose A.F., Wang C., Holtzer R. Effect of cognitive remediation on gait in sedentary seniors. J. Gerontol. A: Biol. Med. Sci. 2010, 65(12):1338-1343. (Dec).
37. Wakana S., Caprihan A., Panzenboeck M.M., et al. Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage 2007, 36(3):630-644. (Jul 1).
38. Wakefield D.B., Moscufo N., Guttmann C.R., et al. White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults. J. Am. Geriatr. Soc. 2010, 58(2):275-281. (Feb).
39. Walter S., Tiemeier H. Variable selection: current practice in epidemiological studies. Eur. J. Epidemiol. 2009, 24(12):733-736.
40. Whitman G.T., Tang Y., Lin A., Baloh R.W. A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Neurology 2001, 57(6):990-994. (Sep 25).
41. Willis S.L., Tennstedt S.L., Marsiske M., et al. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA 2006, 296(23):2805-2814. (Dec 20).
42. Woollacott M., Shumway-Cook A. Attention and the control of posture and gait: a review of an emerging area of research. Gait Posture 2002, 16(1):1-14. (Aug).
43. Wu M., Rosano C., Butters M., et al. A fully automated method for quantifying and localizing white matter hyperintensities on MR images. Psychiatry Res. 2006, 148(2-3):133-142. (Dec 1).
44. Yogev-Seligmann G., Hausdorff J.M., Giladi N. The role of executive function and attention in gait. Mov. Disord. 2008, 23(3):329-342. (Feb 15, quiz 472).
45. Zheng J.J., Delbaere K., Close J.C., Sachdev P.S., Lord S.R. Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review. Stroke 2011, 42(7):2086-2090. (Jul).
46. Zheng J.J., Delbaere K., Close J.C., et al. White matter hyperintensities are an independent predictor of physical decline in community-dwelling older people. Gerontology 2012, 58(5):398-406.
47. Zou H. Regilarization and variable selection via the elastic net. J. R. Stat. Soc. 2005, 301-320.