From implantation to degradation - are poly (L-lactide)/multiwall carbon nanotube composite materials really cytocompatible?

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 10, Issue 5, 2014, Pages e1041-e1051

  Obarzanek Fojt, Magdalena ^a   Elbs Glatz, Yvonne ^a   Lizundia, Erlantz ^b   Diener, Liliane ^a   Sarasua, Jose Ramon ^b   Bruinink, Arie ^a  

^a Laboratory for Materials Biology Interactions   (Switzerland)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Biocompatibility; Bone regeneration; Cytotoxicity; MWCNT; Polylactic acid

Indexed keywords

BIOCOMPATIBILITY; BONE; CELL PROLIFERATION; CYTOTOXICITY; DEGRADATION; LACTIC ACID; MEDICAL APPLICATIONS; NANOCOMPOSITES; REINFORCED PLASTICS; REINFORCEMENT; TISSUE; YARN;

BONE REGENERATION; CARBON-NANOTUBE COMPOSITES; COMPREHENSIVE EVALUATION; HUMAN BONE MARROW STROMAL CELLS; MWCNT; NANOSTRUCTURED COMPOSITES; ORTHOPAEDIC APPLICATIONS; POLY LACTIC ACID;

MULTIWALLED CARBON NANOTUBES (MWCN);

MULTI WALLED NANOTUBE; NANOCOMPOSITE; POLYLACTIDE; BIOMATERIAL; CARBON NANOTUBE; POLYESTER;

ARTICLE; BIOCOMPATIBILITY; CELL SPREADING; COMPOSITE MATERIAL; DEGRADATION; IMMUNOFLUORESCENCE; IN VITRO STUDY; REAL TIME POLYMERASE CHAIN REACTION; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY; CELL LINE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; HUMAN;

BIOCOMPATIBLE MATERIALS; CELL LINE; CELL PROLIFERATION; HUMANS; NANOTUBES, CARBON; POLYESTERS;

EID: 84903522881     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2013.12.012     Document Type: Article

References (45)

1. Barca F., Busa R. Resorbable poly-l-lactic acid mini-staples for the fixation of Akin osteotomies. J Foot Ankle Surg 1997, 36(2):106-111. discussion 60.
2. Brunon J., Duthel R., Fotso M.J., Tudor C. Anterior osteosynthesis of the cervical spine by phusiline bioresorbable screws and plates. Initial results apropos of 5 cases. Neurochirurgie 1994, 40(3):196-202.
3. Burns A.E., Varin J. Poly-l-lactic acid rod fixation results in foot surgery. J Foot Ankle Surg 1998, 37(1):37-41.
4. Pihlajamaki H., Bostman O., Rokkanen P. A biodegradable expansion plug for fixation of the coracoid bone block in the Bristow-Latarjet operation. Int Orthop 1994, 18(2):66-71.
5. Waris T., Pohjonen T., Törmälä P. Self-reinforced absorbable polylactide (SR-PLLA) plates in craniofacial surgery. Eur J Plast Surg 1994, 17(5):236-238.
6. Supronowicz P.R., Ajayan P.M., Ullmann K.R., Arulanandam B.P., Metzger D.W., Bizios R. Novel current-conducting composite substrates for exposing osteoblasts to alternating current stimulation. J Biomed Mater Res 2002, 59(3):499-506.
7. Moon S.-I., Jin F., Lee C.-j., Tsutsumi S., Hyon S.-H. Novel carbon nanotube/poly(l-lactic acid) nanocomposites; their modulus, thermal stability, and electrical conductivity. Macromol Symp 2005, 224(1):287-296.
8. Lee H.H., Sang Shin U., Lee J.H., Kim H.W. Biomedical nanocomposites of poly(lactic acid) and calcium phosphate hybridized with modified carbon nanotubes for hard tissue implants. J Biomed Mater Res B Appl Biomater 2011 Aug, 98B(2):246-254.
9. Zhang D., Kandadai M.A., Cech J., Roth S., Curran S.A. Poly(l-lactide) (PLLA)/multiwalled carbon nanotube (MWCNT) composite: characterization and biocompatibility evaluation. J Phys Chem B 2006, 110(26):12910-12915.
10. Lizundia E., Sarasua J.R., D'Angelo F., Orlacchio A., Martino S., Kenny J.M., et al. Biocompatible poly(l-lactide)/MWCNT nanocomposites: morphological characterization, electrical properties, and stem cell interaction. Macromol Biosci 2012 Jul, 12(7):870-881.
11. Montesano S., Lizundia E., D'Angelo F., Fortunati E., Mattioli S., Morena F., et al. Nanocomposites based on PLLA and multi walled carbon nanotubes support the myogenic differentiation of murine myoblast cell line. ISRN Tissue Engineering 2013, 2013:8.
12. Nair L.S., Laurencin C.T. Biodegradable polymers as biomaterials. Prog Polym Sci 2007, 32(8-9):762-798.
13. Lahiri D., Benaduce A.P., Kos L., Agarwal A. Quantification of carbon nanotube induced adhesion of osteoblast on hydroxyapatite using nano-scratch technique. Nanotechnology 2011, 22(35):957-4484.
14. Hirata E., Uo M., Takita H., Akasaka T., Watari F., Yokoyama A. Development of a 3D collagen scaffold coated with multiwalled carbon nanotubes. J Biomed Mater Res B Appl Biomater 2009, 90B(2):629-634.
15. Li X., Liu H., Niu X., Yu B., Fan Y., Feng Q., et al. The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo. Biomaterials 2012, 33(19):4818-4827.
16. Lizundia E., Oleaga A., Salazar A., Sarasua J.R. Nano- and microstructural effects on thermal properties of poly (l-lactide)/multi-wall carbon nanotube composites. Polymer 2012, 53(12):2412-2421.
17. Lizundia E., Petisco S., Sarasua J.R. Phase-structure and mechanical properties of isothermally melt-and cold-crystallized poly (l-lactide). J Mech Behav Biomed Mater 2013, 17:242-251.
18. Thurnherr T., Su D.S., Diener L., Weinberg G., Manser P., Pfänder N., et al. Comprehensive evaluation of in vitro toxicity of three large-scale produced carbon nanotubes on human Jurkat T cells and a comparison to crocidolite asbestos. Nanotoxicology 2009, 3(4):319-338.
19. Reynolds E.S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 1963, 17:208-212.
20. Athanasiou K.A., Niederauer G.G., Agrawal C.M. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 1996, 17(2):93-102.
21. Waris E., Ashammakhi N., Happonen H., Raatikainen T., Kaarela O., Tormala P., et al. Bioabsorbable miniplating versus metallic fixation for metacarpal fractures. Clin Orthop Relat Res 2003, 410:310-319.
22. Waris E., Ashammakhi N., Raatikainen T., Tormala P., Santavirta S., Konttinen Y.T. Self-reinforced bioabsorbable versus metallic fixation systems for metacarpal and phalangeal fractures: a biomechanical study. J Hand Surg [Am] 2002, 27(5):902-909.
23. Wong E.W., Sheehan P.E., Lieber C.M. Nanobeam mechanics: elasticity, strength, and toughness of nanorods and nanotubes. Science 1997, 277(5334):1971-1975.
24. Overney G., Zhong W., Tománek D. Structural rigidity and low frequency vibrational modes of long carbon tubules. Z Phys D-Atoms, Molecules and Clusters. 1993, 27(1):93-96.
25. Lin C., Wang Y., Lai Y., Yang W., Jiao F., Zhang H., et al. Incorporation of carboxylation multiwalled carbon nanotubes into biodegradable poly(lactic-co-glycolic acid) for bone tissue engineering. Colloids Surf B: Biointerfaces 2011, 83(2):367-375.
26. Krul L.P., Volozhyn A.I., Belov D.A., Poloiko N.A., Artushkevich A.S., Zhdanok S.A., et al. Nanocomposites based on poly-d,l-lactide and multiwall carbon nanotubes. Biomol Eng 2007, 24(1):93-95.
27. Colom X., Carrasco F., Pages P., Canavate J. Effects of different treatments on the interface of HDPE/lignocellulosic fiber composites. Compos Sci Technol 2003, 63(2):161-169.
28. Lizundia E SJ, Armentano I, Kenny JM. Crystallization behavior in PLLA/MWCNT and PLLA/MWCNT-COOH nanocomposites. 2012 [cited 8 04]; 112-8].
29. van der Elst M., Kuiper I., Klein C.P., Patka P., Haarman H.J. The burst phenomenon, an animal model simulating the long-term tissue response on PLLA interlocking nails. J Biomed Mater Res 1996, 30(2):139-143.
30. Misra S.K., Ohashi F., Valappil S.P., Knowles J.C., Roy I., Silva S.R., et al. Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications. Acta Biomater 2010, 6(3):735-742.
31. Usui Y., Aoki K., Narita N., Murakami N., Nakamura I., Nakamura K., et al. Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects. Small 2008, 4(2):240-246.
32. Avti P.K., Sitharaman B. Luminescent single-walled carbon nanotube-sensitized europium nanoprobes for cellular imaging. Int J Nanomedicine 2012, 7:1953-1964.
33. Hirano S., Fujitani Y., Furuyama A., Kanno S. Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells. Toxicol Appl Pharmacol 2010, 249(1):8-15.
34. Tang S., Tang Y., Zhong L., Murat K., Asan G., Yu J., et al. Short- and long-term toxicities of multi-walled carbon nanotubes in vivo and in vitro. J Appl Toxicol 2012 Nov, 32(11):900-912.
35. Rozema F.R., Bergsma J.E., Bos R.R.M., Boering G., Nijenhuis A.J., Pennings A.J., et al. Late degradation simulation of poly(l-lactide). J Mater Sci Mater Med 1994, 5(9-10):575-581.
36. Meyer F., Wardale J., Best S., Cameron R., Rushton N., Brooks R. Effects of lactic acid and glycolic acid on human osteoblasts: a way to understand PLGA involvement in PLGA/calcium phosphate composite failure. J Orthop Res 2012, 30(6):864-871.
37. Dietl K., Renner K., Dettmer K., Timischl B., Eberhart K., Dorn C., et al. Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. J Immunol 2010, 184(3):1200-1209.
38. Wick P., Manser P., Limbach L.K., Dettlaff-Weglikowska U., Krumeich F., Roth S., et al. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 2007, 168(2):121-131.
39. Tang S., Tang Y., Zhong L., Murat K., Asan G., Yu J., et al. Short- and long-term toxicities of multi-walled carbon nanotubes in vivo and in vitro. J Appl Toxicol 2012, 32(11):900-912.
40. Shvedova A., Castranova V., Kisin E., Schwegler-Berry D., Murray A., Gandelsman V., et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxic Environ Health A 2003, 66(20):1909-1926.
41. Mooney E., Dockery P., Greiser U., Murphy M., Barron V. Carbon nanotubes and mesenchymal stem cells: biocompatibility, proliferation and differentiation. Nano Lett 2008, 8(8):2137-2143.
42. Bardi G., Tognini P., Ciofani G., Raffa V., Costa M., Pizzorusso T. Pluronic-coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro. Nanomedicine 2009, 5(1):96-104.
43. Movia D., Prina-Mello A., Bazou D., Volkov Y., Giordani S. Screening the cytotoxicity of single-walled carbon nanotubes using novel 3D tissue-mimetic models. ACS nano 2011, 5(11):9278-9290.
44. Lee H.J., Park J., Yoon O.J., Kim H.W., Lee do Y., Kim do H., et al. Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model. Nature nanotechnology 2011, 6(2):121-125.
45. Hitoshi K., Katoh M., Suzuki T., Ando Y., Nadai M. Differential effects of single-walled carbon nanotubes on cell viability of human lung and pharynx carcinoma cell lines. J Toxicol Sci 2011, 36(3):379-387.