메뉴 건너뛰기




Volumn 55, Issue 7, 2014, Pages 1591-1595

Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: Association with hepatotoxicity

Author keywords

Children; Hepatotoxicity; High dose methotrexate; Homocysteine; Methionine; S adenosylhomocysteine

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINO ACID; BILIRUBIN; FOLINIC ACID; HOMOCYSTEINE; METHIONINE; METHOTREXATE; S ADENOSYLHOMOCYSTEINE; SULFUR; ANTINEOPLASTIC ANTIMETABOLITE;

EID: 84903437101     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2013.850684     Document Type: Article
Times cited : (18)

References (35)
  • 1
    • 0033657707 scopus 로고    scopus 로고
    • High-dose methotrexate in childhood all
    • Moe PJ, Holen A. High-dose methotrexate in childhood ALL.Pediatr Hematol Oncol 2000 ; 17 : 615-622.
    • (2000) Pediatr Hematol Oncol , vol.17 , pp. 615-622
    • Moe, P.J.1    Holen, A.2
  • 2
    • 79551646260 scopus 로고    scopus 로고
    • Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocolfor the treatment of B-cell non-Hodgkin lymphoma and matureB-cell acute lymphoblastic leukemia in childhood
    • Fujita N, Kobayashi R, Takimoto T, et al. Results of the JapanAssociation of Childhood Leukemia Study (JACLS) NHL-98 protocolfor the treatment of B-cell non-Hodgkin lymphoma and matureB-cell acute lymphoblastic leukemia in childhood. Leuk Lymphoma2011 ; 52 : 223-229.
    • (2011) Leuk Lymphoma , vol.52 , pp. 223-229
    • Fujita, N.1    Kobayashi, R.2    Takimoto, T.3
  • 3
    • 0344542098 scopus 로고    scopus 로고
    • Acute neurotoxicityin children with B-precursor acute lymphoid leukemia: An associationwith intermediate-dose intravenous methotrexate and intrathecaltriple therapy-A pediatric oncology group study
    • Mahoney D H J r, Shuster J J, Nitschke R, et al. Acute neurotoxicityin children with B-precursor acute lymphoid leukemia: an associationwith intermediate-dose intravenous methotrexate and intrathecaltriple therapy-a Pediatric Oncology Group study. J Clin Oncol1998 ; 16 : 1712-1722.
    • (1998) J Clin Oncol , vol.16 , pp. 1712-1722
    • Mahoney Jr., D.H.1    Shuster, J.J.2    Nitschke, R.3
  • 4
    • 0031780255 scopus 로고    scopus 로고
    • Clinical and pharmacokineticrisk factors for high-dose methotrexate-induced toxicity in childrenwith acute lymphoblastic leukemia-A logistic regression analysis
    • Rask C, Albertioni F, Bentzen S M, et al. Clinical and pharmacokineticrisk factors for high-dose methotrexate-induced toxicity in childrenwith acute lymphoblastic leukemia-a logistic regression analysis.Acta Oncol 1998 ; 37 : 277-284.
    • (1998) Acta Oncol , vol.37 , pp. 277-284
    • Rask, C.1    Albertioni, F.2    Bentzen, S.M.3
  • 5
    • 42449136257 scopus 로고    scopus 로고
    • Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in childrenwith cancer
    • Cheng K K. Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in childrenwith cancer. Eur J Cancer Care (Engl) 2008; 17: 306-311.
    • (2008) Eur J Cancer Care (Engl) , vol.17 , pp. 306-311
    • Cheng, K.K.1
  • 6
    • 83155176036 scopus 로고    scopus 로고
    • High dose methotrexatechemotherapy: Pharmacokinetics folate and toxicity in osteosarcomapatients
    • Holmboe L, Andersen AM, Mørkrid L, et al. High dose methotrexatechemotherapy: pharmacokinetics, folate and toxicity in osteosarcomapatients. Br J Clin Pharmacol 2012; 73: 106-114.
    • (2012) Br J Clin Pharmacol , vol.73 , pp. 106-114
    • Holmboe, L.1    Andersen, A.M.2    Mørkrid, L.3
  • 7
    • 84873080402 scopus 로고    scopus 로고
    • Comparison of pharmacokineticsand toxicity after high-dose methotrexate treatments in children withacute lymphoblastic leukemia
    • Csordas K, Hegyi M, Eipel OT, et al. Comparison of pharmacokineticsand toxicity after high-dose methotrexate treatments in children withacute lymphoblastic leukemia. Anticancer Drugs 2013; 24: 189-197.
    • (2013) Anticancer Drugs , vol.24 , pp. 189-197
    • Csordas, K.1    Hegyi, M.2    Eipel, O.T.3
  • 8
    • 0021838288 scopus 로고
    • The cellular pharmacology ofmethotrexate
    • Goldman ID, Matherly LH. The cellular pharmacology ofmethotrexate. Pharmacol Ther 1985 ; 28 : 77-102.
    • (1985) Pharmacol Ther , vol.28 , pp. 77-102
    • Goldman, I.D.1    Matherly, L.H.2
  • 9
    • 0021213943 scopus 로고
    • Biological effects of folic acid antagonists withantineoplastic activity
    • Jackson RC. Biological Effects of folic acid antagonists withantineoplastic activity. Pharmacol Ther 1984 ; 25 : 61-82.
    • (1984) Pharmacol Ther , vol.25 , pp. 61-82
    • Jackson, R.C.1
  • 10
    • 0024425508 scopus 로고
    • Changes in plasmamethionine and total homocysteine levels in patients receivingmethotrexate infusions
    • Broxson EH Jr, Stork LC, Allen RH, et al. Changes in plasmamethionine and total homocysteine levels in patients receivingmethotrexate infusions. Cancer Res 1989; 49: 5879-5883.
    • (1989) Cancer Res , vol.49 , pp. 5879-5883
    • Broxson Jr., E.H.1    Stork, L.C.2    Allen, R.H.3
  • 11
    • 0026096815 scopus 로고
    • Plasma homocysteinein children with acute lymphoblastic leukemia: Changes during achemotherapeutic regimen including methotrexate
    • Refsum H, Wesenberg F, Ueland P M. Plasma homocysteinein children with acute lymphoblastic leukemia: changes during achemotherapeutic regimen including methotrexate. Cancer Res1991 ; 51 : 828-835.
    • (1991) Cancer Res , vol.51 , pp. 828-835
    • Refsum, H.1    Wesenberg, F.2    Ueland, P.M.3
  • 12
    • 0042914711 scopus 로고    scopus 로고
    • Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia
    • Kishi S, Griener J, Cheng C, et al. Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia. J Clin Oncol 2003 ; 21 :3084-3091.
    • (2003) J Clin Oncol , vol.21 , pp. 3084-3091
    • Kishi, S.1    Griener, J.2    Cheng, C.3
  • 13
    • 26444433185 scopus 로고    scopus 로고
    • Severe encephalopathy inducedby the fi rst but not the second course of high-dose methotrexatemirrored by plasma homocysteine elevations and preceded byextreme diff erences in pretreatment plasma folate
    • Valik D, Sterba J, Bajciova V, et al. Severe encephalopathy inducedby the fi rst but not the second course of high-dose methotrexatemirrored by plasma homocysteine elevations and preceded byextreme diff erences in pretreatment plasma folate. Oncology 2005 ;69 : 269-272.
    • (2005) Oncology , vol.69 , pp. 269-272
    • Valik, D.1    Sterba, J.2    Bajciova, V.3
  • 14
    • 0034663306 scopus 로고    scopus 로고
    • Evidence for hypomethylation in twochildren with acute lymphoblastic leukemia and leukoencephalopathy
    • Kishi T, Tanaka Y, Ueda K. Evidence for hypomethylation in twochildren with acute lymphoblastic leukemia and leukoencephalopathy.Cancer 2000 ; 89 : 925-931.
    • (2000) Cancer , vol.89 , pp. 925-931
    • Kishi, T.1    Tanaka, Y.2    Ueda, K.3
  • 15
    • 57049127093 scopus 로고    scopus 로고
    • Folate homeostasisin cerebrospinal fl uid during therapy for acute lymphoblastic leukemia
    • Cole PD, Beckwith KA, Vijayanathan V, et al. Folate homeostasisin cerebrospinal fl uid during therapy for acute lymphoblastic leukemia.Pediatr Neurol 2009 ; 40 : 34-41.
    • (2009) Pediatr Neurol , vol.40 , pp. 34-41
    • Cole, P.D.1    Beckwith, K.A.2    Vijayanathan, V.3
  • 16
    • 0023628783 scopus 로고
    • Determination of free and total homocysteinein human plasma by high-performance liquid chromatography withfl uorescence detection
    • Araki A, Sako Y. Determination of free and total homocysteinein human plasma by high-performance liquid chromatography withfl uorescence detection. JChromatogr 1987 ; 422 : 43-52.
    • (1987) J Chromatogr , vol.422 , pp. 43-52
    • Araki, A.1    Sako, Y.2
  • 17
    • 0028566941 scopus 로고
    • Asimple HPLC method for thedetermination of S-adenosylmethionine and S-adenosylhomocysteinein rat tissues: The Effect of vitamin B 6 defi ciency on theseconcentra tions in rat liver
    • She QB, Nagao I, Hayakawa T, et al. Asimple HPLC method for thedetermination of S-adenosylmethionine and S-adenosylhomocysteinein rat tissues: the Effect of vitamin B 6 defi ciency on theseconcentra tions in rat liver. Biochem Biophys Res Commun 1994: 205;1748-1754.
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 1748-1754
    • She, Q.B.1    Nagao, I.2    Hayakawa, T.3
  • 18
    • 40749099021 scopus 로고    scopus 로고
    • Current management and challenges ofmalignant disease in the CNS in paediatric leukaemia
    • Pui C H, Howard S C. Current management and challenges ofmalignant disease in the CNS in paediatric leukaemia. Lancet Oncol2008 ; 9 : 257-268.
    • (2008) Lancet Oncol , vol.9 , pp. 257-268
    • Pui, C.H.1    Howard, S.C.2
  • 19
    • 68949217376 scopus 로고    scopus 로고
    • Advances in individual prediction of methotrexatetoxicity: A review
    • Schmiegelow K. Advances in individual prediction of methotrexatetoxicity: a review. Br J Haematol 2009 ; 146 : 489-503.
    • (2009) Br J Haematol , vol.146 , pp. 489-503
    • Schmiegelow, K.1
  • 20
    • 33745647522 scopus 로고    scopus 로고
    • Understanding and managingmethotrexate nephrotoxicity
    • Widemann BC, Adamson PC. Understanding and managingmethotrexate nephrotoxicity. Oncologist 2006 ; 11 : 694-703.
    • (2006) Oncologist , vol.11 , pp. 694-703
    • Widemann, B.C.1    Adamson, P.C.2
  • 21
    • 84866735479 scopus 로고    scopus 로고
    • Clinical relations ofmethotrexate pharmacokinetics in the treatment for pediatricosteosarcoma
    • Hegyi M, Gulácsi A, Cságoly E, et al. Clinical relations ofmethotrexate pharmacokinetics in the treatment for pediatricosteosarcoma. JCancer Res Clin Oncol 2012 ; 138 : 1697-1702.
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 1697-1702
    • Hegyi, M.1    Gulácsi, A.2    Cságoly, E.3
  • 22
    • 28044447631 scopus 로고    scopus 로고
    • 5, 10-Methylenetetrahydrofolate reductase polymorphismand pharmacogenetics: A new role of single nucleotide polymorphismsin the folate metabolic pathway in human health and disease
    • Kim YI. 5, 10-Methylenetetrahydrofolate reductase polymorphismand pharmacogenetics: a new role of single nucleotide polymorphismsin the folate metabolic pathway in human health and disease. Nutr Rev2005 ; 63 : 398-407.
    • (2005) Nutr Rev , vol.63 , pp. 398-407
    • Kim, Y.I.1
  • 23
    • 33646809781 scopus 로고    scopus 로고
    • The sulfur-containing amino acids: Anoverview
    • Brosnan J T, Brosnan M E. The sulfur-containing amino acids: anoverview. JNutr 2006; 136(6 Suppl.): 1636S-1640S.
    • (2006) JNutr , vol.136 , Issue.6 SUPPL.
    • Brosnan, J.T.1    Brosnan, M.E.2
  • 24
    • 0030966942 scopus 로고    scopus 로고
    • Abnormalhomocysteine metabolism in rheumatoid arthritis
    • Roubenoff R, Dellaripa P, Nadeau M R, et al. Abnormalhomocysteine metabolism in rheumatoid arthritis. Arthritis Rheum1997 ; 40 : 718-722.
    • (1997) Arthritis Rheum , vol.40 , pp. 718-722
    • Roubenoff, R.1    Dellaripa, P.2    Nadeau, M.R.3
  • 25
    • 0037454801 scopus 로고    scopus 로고
    • Effect ofmethylenetetrahydrofolate reductase 677C → T polymorphism ontoxicity and homocysteine plasma level after chronic methotrexatetreatment of ovarian cancer patients
    • Toffoli G, Russo A, Innocenti F, et al. Effect ofmethylenetetrahydrofolate reductase 677C → T polymorphism ontoxicity and homocysteine plasma level after chronic methotrexatetreatment of ovarian cancer patients. Int J Cancer 2003 ; 103 :294-299.
    • (2003) Int J Cancer , vol.103 , pp. 294-299
    • Toffoli, G.1    Russo, A.2    Innocenti, F.3
  • 26
    • 30744436574 scopus 로고    scopus 로고
    • Relationship between plasmaS-adenosylhomocysteine concentration and glomerular fi ltration ratein children
    • Jabs K, Koury M J, Dupont W D, et al. Relationship between plasmaS-adenosylhomocysteine concentration and glomerular fi ltration ratein children. Metabolism 2006; 55: 252-257.
    • (2006) Metabolism , vol.55 , pp. 252-257
    • Jabs, K.1    Koury, M.J.2    Dupont, W.D.3
  • 27
    • 38949111041 scopus 로고    scopus 로고
    • Plasma S-adenosylhomocysteineis a better biomarker of atherosclerosis than homocysteine inapolipoprotein E-defi cient mice fed high dietary methionine
    • Liu C, Wang Q, Guo H, et al. plasma S-adenosylhomocysteineis a better biomarker of atherosclerosis than homocysteine inapolipoprotein E-defi cient mice fed high dietary methionine. JNutr2008 ; 138 : 311-315.
    • (2008) JNutr , vol.138 , pp. 311-315
    • Liu, C.1    Wang, Q.2    Guo, H.3
  • 28
    • 84903455892 scopus 로고    scopus 로고
    • The role of the MTHFR677C T polymorphism in methotrexate-induced liver toxicity: Ameta-analysis in patients with cancer
    • May 7. [Epub ahead of print]
    • Hagleitner MM, Coenen MJ, Aplenc R, et al. The role of the MTHFR677C-T polymorphism in methotrexate-induced liver toxicity: ameta-analysis in patients with cancer. Pharmacogenomics J 2013May 7. [Epub ahead of print]
    • (2013) Pharmacogenomics J
    • Hagleitner, M.M.1    Coenen, M.J.2    Aplenc, R.3
  • 29
    • 68449090047 scopus 로고    scopus 로고
    • Methylenetetrahydrofolatereductase C677T and A1298C gene polymorphism and therapyrelatedtoxicity in children treated for acute lymphoblastic leukemiaand non-Hodgkin lymphoma
    • Kantar M, Kosova B, Cetingul N, et al. Methylenetetrahydrofolatereductase C677T and A1298C gene polymorphism and therapyrelatedtoxicity in children treated for acute lymphoblastic leukemiaand non-Hodgkin lymphoma. Leuk Lymphoma 2009; 50: 912-917.
    • (2009) Leuk Lymphoma , vol.50 , pp. 912-917
    • Kantar, M.1    Kosova, B.2    Cetingul, N.3
  • 30
    • 67649980707 scopus 로고    scopus 로고
    • Alcoholic liver disease and methioninemetabolism
    • Kharbanda K K. Alcoholic liver disease and methioninemetabolism. Semin Liver Dis 2009; 29: 155-165.
    • (2009) Semin Liver Dis , vol.29 , pp. 155-165
    • Kharbanda, K.K.1
  • 31
    • 10044236724 scopus 로고    scopus 로고
    • Folate, homocysteine, and cobalamin status in patients with rheumatoidarthritis treated with methotrexate, and the Effect of low dose folic acidsupplement
    • Homung N, Ellingsen T, Stengaard-Pedersen K, et al. Folate, homocysteine, and cobalamin status in patients with rheumatoidarthritis treated with methotrexate, and the Effect of low dose folic acidsupplement. JRheumatol 2004 ; 31 : 2374-2381.
    • (2004) J Rheumatol , vol.31 , pp. 2374-2381
    • Homung, N.1    Ellingsen, T.2    Stengaard-Pedersen, K.3
  • 32
    • 0014473826 scopus 로고
    • Hypoalbuminemicand hypocholesteroemic Effect of L-asparaginase (NSC-109 229)treatment in man-A preliminary report
    • Canellos G P, Haskell C M, Arseneau J, et al. Hypoalbuminemicand hypocholesteroemic Effect of L-asparaginase (NSC-109, 229)treatment in man-a preliminary report. Cancer Chemother Rep1969 ; 53 : 67-69.
    • (1969) Cancer Chemother Rep , vol.53 , pp. 67-69
    • Canellos, G.P.1    Haskell, C.M.2    Arseneau, J.3
  • 33
    • 60749116860 scopus 로고    scopus 로고
    • Oxidative and nitrosativestress and apoptosis in the liver of rats fed on high methionine diet: Protective Effect of taurine
    • Yalçinkaya S, Unlüçerçi Y, Giris ? M, et al. Oxidative and nitrosativestress and apoptosis in the liver of rats fed on high methionine diet:protective Effect of taurine. Nutrition 2009 ; 25 : 436-444.
    • (2009) Nutrition , vol.25 , pp. 436-444
    • Yalçinkaya, S.1    Unlüçerçi, Y.2    Giris, M.3
  • 34
    • 84863027351 scopus 로고    scopus 로고
    • Folic acid supplementation reducesoxidative stress and hepatic toxicity in rats treated chronically withethanol
    • Lee S J, Kang M H, Min H. Folic acid supplementation reducesoxidative stress and hepatic toxicity in rats treated chronically withethanol. Nutr Res Pract 2011; 5: 520-526.
    • (2011) Nutr Res Pract , vol.5 , pp. 520-526
    • Lee, S.J.1    Kang, M.H.2    Min, H.3
  • 35
    • 80052461557 scopus 로고    scopus 로고
    • Hyper-homocysteinemia: Aa novel risk factoror a powerful marker for cardiovascular diseases? Pathogenetic andtherapeutical uncertainties
    • Cacciapuoti F. Hyper-homocysteinemia: a novel risk factoror a powerful marker for cardiovascular diseases? Pathogenetic andtherapeutical uncertainties. JTh romb Th rombolysis 2011; 32: 82-88.
    • (2011) JTh Romb Th Rombolysis , vol.32 , pp. 82-88
    • Cacciapuoti, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.