High dose methotrexate chemotherapy: Pharmacokinetics, folate and toxicity in osteosarcoma patients

British Journal of Clinical Pharmacology

Volumn 73, Issue 1, 2012, Pages 106-114

  Holmboe, Laila ^a,e   Andersen, Anders M ^a   Mørkrid, Lars ^a,b   Slørdal, Lars ^c,d   Hall, Kirsten Sundby ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^e ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

7 hydroxy methotrexate; Folate; Gender; Methotrexate; Osteosarcoma; Toxicity

Indexed keywords

FOLIC ACID; METHOTREXATE;

ADOLESCENT; ADVERSE OUTCOME; AREA UNDER THE CURVE; ARTICLE; BLOOD TOXICITY; DERMATITIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG MEGADOSE; DRUG METABOLISM; ERYTHROCYTE; FEMALE; HUMAN; LABORATORY TEST; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MUCOSAL DISEASE; MULTIPLE CYCLE TREATMENT; NEPHROTOXICITY; OSTEOSARCOMA; PLEURISY; PRIORITY JOURNAL; SIDE EFFECT;

ADOLESCENT; ADULT; AGE FACTORS; ANTIMETABOLITES, ANTINEOPLASTIC; AREA UNDER CURVE; BONE NEOPLASMS; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLIC ACID; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; OSTEOSARCOMA; REDUCED FOLATE CARRIER PROTEIN; SEX FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 83155176036     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2011.04054.x     Document Type: Article

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