RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Yu, Ze Yan ^a,b,c   Tan, Ju Chiat ^a   McMahon, Aisling C ^a,b   Iismaa, Siiri E ^a,c   Xiao, Hui ^a   Kesteven, Scott H ^a   Reichelt, Melissa E ^a   Mohl, Marion C ^a   Smith, Nicola J ^a,c   Fatkin, Diane ^a,b,c   Allen, David ^d   Head, Stewart I ^c   Graham, Robert M ^a,b,c   Feneley, Michael P ^a,b,c  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; ANGIOTENSIN II; CALCIUM ION; CARDIAC MYOSIN LIGHT CHAIN 2; MYOSIN; MYOSIN PHOSPHATASE TARGETING SUBUNIT 1; N [5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 5,6,7,8 TETRAHYDRO 2 HYDROXY 1 NAPHTHYL]METHANESULFONAMIDE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM; ROCK1 PROTEIN, MOUSE;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM EFFECT; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MALE; MOUSE; NONHUMAN; PLEIOTROPY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; ANIMAL; HEART CONTRACTION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CALCIUM; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, ALPHA-1; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84903398816     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099024     Document Type: Article

References (25)

1. Lin F, Owens WA, Chen S, Stevens ME, Kesteven S, et al. (2001) Targeted alpha(1A)- adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy. Circ Res 89: 343-350. (Pubitemid 34132673)
2. Knowlton KU, Michel MC, Itani M, Shubeita HE, Ishihara K, et al. (1993) The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem 268: 15374-15380. (Pubitemid 23222024)
3. Du XJ, Fang L, Gao XM, Kiriazis H, Feng X, et al. (2004) Genetic enhancement of ventricular contractility protects against pressure- overloadinduced cardiac dysfunction. J Mol Cell Cardiol 37: 979-987. (Pubitemid 39446823)
4. Du XJ, Gao XM, Kiriazis H, Moore XL, Ming Z, et al. (2006) Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival. Cardiovasc Res 71: 735-743. (Pubitemid 44848290)
5. Chaulet H, Lin F, Guo J, Owens WA, Michalicek J, et al. (2006) Sustained augmentation of cardiac alpha1A-adrenergic drive results in pathological remodeling with contractile dysfunction, progressive fibrosis and reactivation of matricellular protein genes. J Mol Cell Cardiol 40: 540-552.
6. Head SI, Stephenson DG, Williams DA (1990) Properties of enzymatically isolated skeletal fibres from mice with muscular dystrophy. J Physiol 422: 351-367. (Pubitemid 20109864)
7. Mohl MC, Iismaa SE, Xiao XH, Friedrich O, Wagner S, et al. (2011) Regulation of murine cardiac contractility by activation of alpha(1A)-adrenergic receptor-operated Ca(2+) entry. Cardiovasc Res 91: 310-319.
8. D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, et al. (1997) Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A 94: 8121-8126. (Pubitemid 27343787)
9. Paradis P, Dali-Youcef N, Paradis FW, Thibault G, Nemer M (2000) Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci U S A 97: 931-936. (Pubitemid 30070412)
10. Zhao X, Park J, Ho D, Gao S, Yan L, et al. (2012) Cardiomyocyte overexpression of the alpha1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning. Am J Physiol Heart Circ Physiol 302: H1614-1624.
11. Satoh N, Suter TM, Liao R, Colucci WS (2000) Chronic alpha-adrenergic receptor stimulation modulates the contractile phenotype of cardiac myocytes in vitro. Circulation 102: 2249-2254.
12. Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, et al. (1994) Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science 264: 582-586.
13. Solaro RJ, de Tombe PP (2008) Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function. Cardiovasc Res 77: 616-618. (Pubitemid 351301879)
14. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, et al. (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273: 245-248. (Pubitemid 26285892)
15. Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, et al. (2004) PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med 10: 248-254. (Pubitemid 38667614)
16. Perez DM, Hwa J, Gaivin R, Mathur M, Brown F, et al. (1996) Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor. Mol Pharmacol 49: 112-122. (Pubitemid 26037325)
17. Smith NJ, Chan HW, Qian H, Bourne AM, Hannan KM, et al. (2011) Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy. Hypertension 57: 973-980.
18. DerMardirossian C, Bokoch GM (2005) GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol 15: 356-363.
19. van der Velden J, Papp Z, Zaremba R, Boontje NM, de Jong JW, et al. (2003) Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins. Cardiovasc Res 57: 37-47.
20. Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, et al. (2012) Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation 126: 2575-2588.
21. Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, et al. (2004) Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109: 2234-2239. (Pubitemid 38625402)
22. Kobayashi N, Horinaka S, Mita S, Nakano S, Honda T, et al. (2002) Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts. Cardiovasc Res 55: 757-767.
23. Chu L, Norota I, Endoh M (2005) Differential inhibition by the Rho kinase inhibitor Y-27632 of the increases in contractility and Ca2+ transients induced by endothelin-1 in rabbit ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol 371: 185-194. (Pubitemid 40768410)
24. Hamid SA, Bower HS, Baxter GF (2007) Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium. Am J Physiol Heart Circ Physiol 292: H2598-2606. (Pubitemid 47084509)
25. Lin G, Craig GP, Zhang L, Yuen VG, Allard M, et al. (2007) Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats. Cardiovasc Res 75: 51-58. (Pubitemid 46873512)