-
1
-
-
0032101159
-
Implications of critical illness, injury, and sepsis on lean body mass and nutritional needs
-
Hill GL (1998) Implications of critical illness, injury, and sepsis on lean body mass and nutritional needs. Nutrition 14: 557-558.
-
(1998)
Nutrition
, vol.14
, pp. 557-558
-
-
Hill, G.L.1
-
2
-
-
52449093714
-
Pathophysiologic response to severe burn injury
-
Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, et al. (2008) Pathophysiologic response to severe burn injury. Ann Surg 248: 387-401.
-
(2008)
Ann Surg
, vol.248
, pp. 387-401
-
-
Jeschke, M.G.1
Chinkes, D.L.2
Finnerty, C.C.3
Kulp, G.4
Suman, O.E.5
-
3
-
-
0017149373
-
Nutritional care of the injured and/or septic patient
-
Blackburn GL, Bistrian BR (1976) Nutritional care of the injured and/or septic patient. Surg Clin North Am 56: 1195-1224.
-
(1976)
Surg Clin North Am
, vol.56
, pp. 1195-1224
-
-
Blackburn, G.L.1
Bistrian, B.R.2
-
5
-
-
79955022431
-
Quantification of lean tissue losses during cancer and HIV infection/AIDS
-
Thibault R, Cano N, Pichard C (2011) Quantification of lean tissue losses during cancer and HIV infection/AIDS. Curr Opin Clin Nutr Metab Care 14: 261-267.
-
(2011)
Curr Opin Clin Nutr Metab Care
, vol.14
, pp. 261-267
-
-
Thibault, R.1
Cano, N.2
Pichard, C.3
-
6
-
-
79951882924
-
Cancer cachexia: Traditional therapies and novel molecular mechanism-based approaches to treatment
-
Kumar NB, Kazi A, Smith T, Crocker T, Yu D, et al. (2010) Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment. Curr Treat Options Oncol 11: 107-117.
-
(2010)
Curr Treat Options Oncol
, vol.11
, pp. 107-117
-
-
Kumar, N.B.1
Kazi, A.2
Smith, T.3
Crocker, T.4
Yu, D.5
-
8
-
-
79955133814
-
mTor signaling in skeletal muscle during sepsis and inflammation: Where does it all go wrong?
-
Frost RA, Lang CH (2011) mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong? Physiology (Bethesda) 26: 83-96.
-
(2011)
Physiology (Bethesda)
, vol.26
, pp. 83-96
-
-
Frost, R.A.1
Lang, C.H.2
-
9
-
-
33947687136
-
Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle
-
DOI 10.2119/2006-00071.Lang
-
Lang CH, Frost RA (2006) Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle. Mol Med 12: 291-299. (Pubitemid 46489822)
-
(2006)
Molecular Medicine
, vol.12
, Issue.11-12
, pp. 291-299
-
-
Lang, C.H.1
Frost, R.A.2
-
10
-
-
71949105169
-
Age and tissue specific differences in the development of acute insulin resistance following injury
-
Zhai L, Messina JL (2009) Age and tissue specific differences in the development of acute insulin resistance following injury. J Endocrinol 203: 365-374.
-
(2009)
J Endocrinol
, vol.203
, pp. 365-374
-
-
Zhai, L.1
Messina, J.L.2
-
11
-
-
0038001595
-
Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation
-
Hong-Brown LQ, Brown CR, Cooney RN, Frost RA, Lang CH (2003) Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Am J Physiol Endocrinol Metab 285: E63-72. (Pubitemid 36736362)
-
(2003)
American Journal of Physiology - Endocrinology and Metabolism
, vol.285
, Issue.1
-
-
Hong-Brown, L.Q.1
Brown, C.R.2
Cooney, R.N.3
Frost, R.A.4
Lang, C.H.5
-
12
-
-
78751628125
-
Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis
-
Kazi AA, Pruznak AM, Frost RA, Lang CH (2011) Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis. Shock 35: 117-125.
-
(2011)
Shock
, vol.35
, pp. 117-125
-
-
Kazi, A.A.1
Pruznak, A.M.2
Frost, R.A.3
Lang, C.H.4
-
13
-
-
77952662500
-
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine
-
Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC (2010) Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab 298: E1283-1294.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
-
-
Lang, C.H.1
Frost, R.A.2
Bronson, S.K.3
Lynch, C.J.4
Vary, T.C.5
-
14
-
-
78650809483
-
Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes
-
Frost RA, Pereyra E, Lang CH (2011) Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes. Endocrinology 152: 151-163.
-
(2011)
Endocrinology
, vol.152
, pp. 151-163
-
-
Frost, R.A.1
Pereyra, E.2
Lang, C.H.3
-
15
-
-
70349664576
-
Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity
-
Frost RA, Nystrom GJ, Lang CH (2009) Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity. Shock 32: 416-426.
-
(2009)
Shock
, vol.32
, pp. 416-426
-
-
Frost, R.A.1
Nystrom, G.J.2
Lang, C.H.3
-
16
-
-
33845222306
-
Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha
-
DOI 10.1016/j.metabol.2006.08.025, PII S0026049506003180
-
Lang CH, Frost RA (2007) Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha. Metabolism 56: 49-57. (Pubitemid 44855012)
-
(2007)
Metabolism: Clinical and Experimental
, vol.56
, Issue.1
, pp. 49-57
-
-
Lang, C.H.1
Frost, R.A.2
-
17
-
-
18444389773
-
TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and elF4E in cardiac muscle
-
DOI 10.1002/jcb.20311
-
Lang CH, Pruznak AM, Frost RA (2005) TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle. J Cell Biochem 94: 419-431. (Pubitemid 41420318)
-
(2005)
Journal of Cellular Biochemistry
, vol.94
, Issue.2
, pp. 419-431
-
-
Lang, C.H.1
Pruznak, A.M.2
Frost, R.A.3
-
18
-
-
0029984415
-
IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis
-
Lang CH, Fan J, Cooney R, Vary TC (1996) IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis. Am J Physiol 270: E430-437.
-
(1996)
Am J Physiol
, vol.270
-
-
Lang, C.H.1
Fan, J.2
Cooney, R.3
Vary, T.C.4
-
19
-
-
79960831814
-
Novel events in the molecular regulation of muscle mass in critically ill patients
-
Constantin D, McCullough J, Mahajan RP, Greenhaff PL (2011) Novel events in the molecular regulation of muscle mass in critically ill patients. J Physiol 589: 3883-3895.
-
(2011)
J Physiol
, vol.589
, pp. 3883-3895
-
-
Constantin, D.1
McCullough, J.2
Mahajan, R.P.3
Greenhaff, P.L.4
-
20
-
-
84884676252
-
Nutrient signaling to mTOR and cell growth
-
Jewell JL, Guan KL (2013) Nutrient signaling to mTOR and cell growth. Trends Biochem Sci 38: 233-242.
-
(2013)
Trends Biochem Sci
, vol.38
, pp. 233-242
-
-
Jewell, J.L.1
Guan, K.L.2
-
21
-
-
0030806524
-
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin- sensitive point immediately upstream of p70(s6k)
-
von Manteuffel SR, Dennis PB, Pullen N, Gingras AC, Sonenberg N, et al. (1997) The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol Cell Biol 17: 5426-5436. (Pubitemid 27357640)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.9
, pp. 5426-5436
-
-
Von Manteuffel, S.R.1
Dennis, P.B.2
Pullen, N.3
Gingras, A.-C.4
Sonenberg, N.5
Thomas, G.6
-
22
-
-
33846806078
-
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
-
DOI 10.1172/JCI29528
-
Le Bacquer O, Petroulakis E, Paglialunga S, Poulin F, Richard D, et al. (2007) Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest 117: 387-396. (Pubitemid 46203967)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.2
, pp. 387-396
-
-
Le, B.O.1
Petroulakis, E.2
Paglialunga, S.3
Poulin, F.4
Richard, D.5
Cianflone, K.6
Sonenberg, N.7
-
23
-
-
0034770191
-
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
-
DOI 10.1038/nm1001-1128
-
Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, et al. (2001) Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med 7: 1128-1132. (Pubitemid 33010021)
-
(2001)
Nature Medicine
, vol.7
, Issue.10
, pp. 1128-1132
-
-
Tsukiyama-Kohara, K.1
Poulin, F.2
Kohara, M.3
DeMaria, C.T.4
Cheng, A.5
Wu, Z.6
Gingras, A.-C.7
Katsume, A.8
Elchebly, M.9
Spiegelman, B.M.10
Harper, M.-E.11
Tremblay, M.L.12
Sonenberg, N.13
-
24
-
-
0032577691
-
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
-
DOI 10.1074/jbc.273.22.14002
-
Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (1998) 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem 273: 14002-14007. (Pubitemid 28268456)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.22
, pp. 14002-14007
-
-
Poulin, F.1
Gingras, A.-C.2
Olsen, H.3
Chevalier, S.4
Sonenberg, N.5
-
25
-
-
0028034233
-
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
-
Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, et al. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371: 762-767.
-
(1994)
Nature
, vol.371
, pp. 762-767
-
-
Pause, A.1
Belsham, G.J.2
Gingras, A.C.3
Donze, O.4
Lin, T.A.5
-
26
-
-
0028786952
-
Repression of cap-dependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E
-
Haghighat A, Mader S, Pause A, Sonenberg N (1995) Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J 14: 5701-5709.
-
(1995)
EMBO J
, vol.14
, pp. 5701-5709
-
-
Haghighat, A.1
Mader, S.2
Pause, A.3
Sonenberg, N.4
-
27
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
-
Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N (1998) 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 12: 502-513. (Pubitemid 28101013)
-
(1998)
Genes and Development
, vol.12
, Issue.4
, pp. 502-513
-
-
Gingras, A.-C.1
Kennedy, S.G.2
O'Leary, M.A.3
Sonenberg, N.4
Hay, N.5
-
28
-
-
77956679005
-
BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice
-
Lang CH, Lynch CJ, Vary TC (2010) BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice. Am J Physiol Regul Integr Comp Physiol 299: R935-944.
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.299
-
-
Lang, C.H.1
Lynch, C.J.2
Vary, T.C.3
-
29
-
-
65549162587
-
Local insulin-like growth factor I prevents sepsis-induced muscle atrophy
-
Nystrom G, Pruznak A, Huber D, Frost RA, Lang CH (2009) Local insulin-like growth factor I prevents sepsis-induced muscle atrophy. Metabolism 58: 787-797.
-
(2009)
Metabolism
, vol.58
, pp. 787-797
-
-
Nystrom, G.1
Pruznak, A.2
Huber, D.3
Frost, R.A.4
Lang, C.H.5
-
30
-
-
68049100485
-
Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle
-
Nystrom GJ, Lang CH (2008) Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle. Int J Clin Exp Med 1: 50-63.
-
(2008)
Int J Clin Exp Med
, vol.1
, pp. 50-63
-
-
Nystrom, G.J.1
Lang, C.H.2
-
31
-
-
33646464984
-
Animal research. Harmonization of animal care and use guidance
-
Demers G, Griffin G, De Vroey G, Haywood JR, Zurlo J, et al. (2006) Animal research. Harmonization of animal care and use guidance. Science 312: 700-701.
-
(2006)
Science
, vol.312
, pp. 700-701
-
-
Demers, G.1
Griffin, G.2
De Vroey, G.3
Haywood, J.R.4
Zurlo, J.5
-
32
-
-
84862660964
-
Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice
-
Lang SM, Kazi AA, Hong-Brown L, Lang CH (2012) Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice. PLoS One 7: e38910.
-
(2012)
PLoS One
, vol.7
-
-
Lang, S.M.1
Kazi, A.A.2
Hong-Brown, L.3
Lang, C.H.4
-
33
-
-
79952702945
-
Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis
-
Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, et al. (2011) Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Mol Psychiatry 16: 569-581.
-
(2011)
Mol Psychiatry
, vol.16
, pp. 569-581
-
-
Albaugh, V.L.1
Judson, J.G.2
She, P.3
Lang, C.H.4
Maresca, K.P.5
-
34
-
-
84934435176
-
Assessing effects of alcohol consumption on protein synthesis in striated muscles
-
Vary TC, Lang CH (2008) Assessing effects of alcohol consumption on protein synthesis in striated muscles. Methods Mol Biol 447: 343-355.
-
(2008)
Methods Mol Biol
, vol.447
, pp. 343-355
-
-
Vary, T.C.1
Lang, C.H.2
-
35
-
-
61949099952
-
Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes
-
Huang BP, Wang Y, Wang X, Wang Z, Proud CG (2009) Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes. Am J Physiol Heart Circ Physiol 296: H505-514.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.296
-
-
Huang, B.P.1
Wang, Y.2
Wang, X.3
Wang, Z.4
Proud, C.G.5
-
36
-
-
84871178729
-
Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis
-
Dennis MD, Jefferson LS, Kimball SR (2012) Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J Biol Chem 287: 42890-42899.
-
(2012)
J Biol Chem
, vol.287
, pp. 42890-42899
-
-
Dennis, M.D.1
Jefferson, L.S.2
Kimball, S.R.3
-
37
-
-
1642355123
-
A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin
-
DOI 10.1128/MCB.24.7.2986-2997.2004
-
Browne GJ, Proud CG (2004) A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol 24: 2986-2997. (Pubitemid 38381287)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.7
, pp. 2986-2997
-
-
Browne, G.J.1
Proud, C.G.2
-
38
-
-
0035941020
-
Identification of ubiquitin ligases required for skeletal Muscle Atrophy
-
DOI 10.1126/science.1065874
-
Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, et al. (2001) Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294: 1704-1708. (Pubitemid 33104839)
-
(2001)
Science
, vol.294
, Issue.5547
, pp. 1704-1708
-
-
Bodine, S.C.1
Latres, E.2
Baumhueter, S.3
Lai, V.K.-M.4
Nunez, L.5
Clarke, B.A.6
Poueymirou, W.T.7
Panaro, F.J.8
Erqian, N.9
Dharmarajan, K.10
Pan, Z.-Q.11
Valenzuela, D.M.12
Dechiara, T.M.13
Stitt, T.N.14
Yancopoulos, G.D.15
Glass, D.J.16
-
39
-
-
84882733761
-
Mechanisms regulating skeletal muscle growth and atrophy
-
Schiaffino S, Dyar KA, Ciciliot S, Blaauw B, Sandri M (2013) Mechanisms regulating skeletal muscle growth and atrophy. FEBS J 280: 4294-4314.
-
(2013)
FEBS J
, vol.280
, pp. 4294-4314
-
-
Schiaffino, S.1
Dyar, K.A.2
Ciciliot, S.3
Blaauw, B.4
Sandri, M.5
-
40
-
-
34447644976
-
Protein kinase B/Akt: A nexus of growth factor and cytokine signaling in determining muscle mass
-
Frost RA, Lang CH (2007) Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass. J Appl Physiol (1985) 103: 378-387.
-
(2007)
J Appl Physiol (1985)
, vol.103
, pp. 378-387
-
-
Frost, R.A.1
Lang, C.H.2
-
41
-
-
69749089808
-
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle
-
Phillips SM, Glover EI, Rennie MJ (2009) Alterations of protein turnover underlying disuse atrophy in human skeletal muscle. J Appl Physiol (1985) 107: 645-654.
-
(2009)
J Appl Physiol (1985)
, vol.107
, pp. 645-654
-
-
Phillips, S.M.1
Glover, E.I.2
Rennie, M.J.3
-
42
-
-
33846875462
-
Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle
-
DOI 10.1152/ajpendo.00359.2006
-
Frost RA, Nystrom GJ, Jefferson LS, Lang CH (2007) Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle. Am J Physiol Endocrinol Metab 292: E501-512. (Pubitemid 46220575)
-
(2007)
American Journal of Physiology - Endocrinology and Metabolism
, vol.292
, Issue.2
-
-
Frost, R.A.1
Nystrom, G.J.2
Jefferson, L.S.3
Lang, C.H.4
-
43
-
-
79957563749
-
A class IA PI3K controls inflammatory cytokine production in human neutrophils
-
Fortin CF, Cloutier A, Ear T, Sylvain-Prevost S, Mayer TZ, et al. (2011) A class IA PI3K controls inflammatory cytokine production in human neutrophils. Eur J Immunol 41: 1709-1719.
-
(2011)
Eur J Immunol
, vol.41
, pp. 1709-1719
-
-
Fortin, C.F.1
Cloutier, A.2
Ear, T.3
Sylvain-Prevost, S.4
Mayer, T.Z.5
-
44
-
-
1942453838
-
A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 Is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A
-
DOI 10.1128/MCB.24.9.3894-3906.2004
-
Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, et al. (2004) A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol 24: 3894-3906. (Pubitemid 38496167)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.9
, pp. 3894-3906
-
-
Yang, H.-S.1
Cho, M.-H.2
Zakowicz, H.3
Hegamyer, G.4
Sonenberg, N.5
Colburn, N.H.6
-
45
-
-
79954609242
-
Synergistic activation of eIF4A by eIF4B and eIF4G
-
Nielsen KH, Behrens MA, He Y, Oliveira CL, Jensen LS, et al. (2011) Synergistic activation of eIF4A by eIF4B and eIF4G. Nucleic Acids Res 39: 2678-2689.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 2678-2689
-
-
Nielsen, K.H.1
Behrens, M.A.2
He, Y.3
Oliveira, C.L.4
Jensen, L.S.5
|