A Computational Model of the Fetal Circulation to Quantify Blood Redistribution in Intrauterine Growth Restriction

PLoS Computational Biology

Volumn 10, Issue 6, 2014, Pages

  Garcia Canadilla, Patricia ^a,b   Rudenick, Paula A ^c   Crispi, Fatima ^a   Cruz Lemini, Monica ^a   Palau, Georgina ^b   Camara, Oscar ^b   Gratacos, Eduard ^a   Bijens, Bart H ^b,d  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; COMPUTATION THEORY; COMPUTATIONAL METHODS; HEMODYNAMICS;

BLOOD FLOW; CLINICAL PRACTICES; CLINICAL STUDY; COMPUTATIONAL MODELLING; FETAL CIRCULATION; FLOW CHANGES; FLOW REDISTRIBUTION; INTRAUTERINE GROWTH RESTRICTION; MIDDLE CEREBRAL ARTERY; OXYGENATED BLOOD;

BRAIN;

ALGORITHM; ARTERY BLOOD FLOW; ARTICLE; ASCENDING AORTA; BRAIN VASCULAR RESISTANCE; CALIBRATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DATA ANALYSIS; DESCENDING AORTA; DISEASE SEVERITY; DOPPLER FLOWMETRY; DUCTUS ARTERIOSUS; FETUS CIRCULATION; GESTATIONAL AGE; HEMODYNAMICS; INTERNAL CAROTID ARTERY; INTRAUTERINE GROWTH RETARDATION; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MIDDLE CEREBRAL ARTERY; PULMONARY ARTERY; SUBCLAVIAN ARTERY; YOUNG MODULUS; AORTA; BIOLOGICAL MODEL; COMPUTER SIMULATION; FEMALE; FETUS; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA; PREGNANCY; THIRD TRIMESTER PREGNANCY; VASCULARIZATION;

AORTA; COMPUTER SIMULATION; FEMALE; FETAL GROWTH RETARDATION; FETUS; HEMODYNAMICS; HUMANS; MIDDLE CEREBRAL ARTERY; MODELS, CARDIOVASCULAR; PLACENTA; PREGNANCY; PREGNANCY TRIMESTER, THIRD;

EID: 84903388629     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003667     Document Type: Article

References (53)

1. Alberry M, Soothill P, (2007) Management of fetal growth restriction. Arch Dis Child Fetal Neonatal Ed 92: F62-67.
2. Gratacos E, (2013) Towards an integrated third-trimester screening in pregnancy. Fetal Diagn Ther 33: 141-142.
3. Cruz-Lemini M, Crispi F, Van Mieghem T, Pedraza D, Cruz-Martinez R, et al. (2012) Risk of perinatal death in early-onset intrauterine growth restriction according to gestational age and cardiovascular Doppler indices: a multicenter study. Fetal Diagn Ther 32: 116-122.
4. Eixarch E, Meler E, Iraola A, Illa M, Crispi F, et al. (2008) Neurodevelopmental outcome in 2-year-old infants who were small-for-gestational age term fetuses with cerebral blood flow redistribution. Ultrasound Obstet Gynecol 32: 894-899.
5. Figueras F, Cruz-Martinez R, Sanz-Cortes M, Arranz A, Illa M, et al. (2011) Neurobehavioral outcomes in preterm, growth-restricted infants with and without prenatal advanced signs of brain-sparing. Ultrasound Obstet Gynecol 38: 288-294.
6. Fouron JC, Gosselin J, Raboisson MJ, Lamoureux J, Tison CA, et al. (2005) The relationship between an aortic isthmus blood flow velocity index and the postnatal neurodevelopmental status of fetuses with placental circulatory insufficiency. Am J Obstet Gynecol 192: 497-503.
7. Hernandez-Andrade E, Crispi F, Benavides-Serralde JA, Plasencia W, Diesel HF, et al. (2009) Contribution of the myocardial performance index and aortic isthmus blood flow index to predicting mortality in preterm growth-restricted fetuses. Ultrasound Obstet Gynecol 34: 430-436.
8. Figueras F, Benavides A, Del Rio M, Crispi F, Eixarch E, et al. (2009) Monitoring of fetuses with intrauterine growth restriction: longitudinal changes in ductus venosus and aortic isthmus flow. Ultrasound Obstet Gynecol 33: 39-43.
9. Makikallio K, Jouppila P, Rasanen J, (2002) Retrograde net blood flow in the aortic isthmus in relation to human fetal arterial and venous circulations. Ultrasound Obstet Gynecol 19: 147-152.
10. Kiserud T, Ebbing C, Kessler J, Rasmussen S, (2006) Fetal cardiac output, distribution to the placenta and impact of placental compromise. Ultrasound Obstet Gynecol 28: 126-136.
11. Acharya G, Tronnes A, Rasanen J, (2011) Aortic isthmus and cardiac monitoring of the growth-restricted fetus. Clin Perinatol 38: 113-125, vi-vii.
12. Bonnin P, Fouron JC, Teyssier G, Sonesson SE, Skoll A, (1993) Quantitative assessment of circulatory changes in the fetal aortic isthmus during progressive increase of resistance to umbilical blood flow. Circulation 88: 216-222.
13. Fouron JC, Skoll A, Sonesson SE, Pfizenmaier M, Jaeggi E, et al. (1999) Relationship between flow through the fetal aortic isthmus and cerebral oxygenation during acute placental circulatory insufficiency in ovine fetuses. Am J Obstet Gynecol 181: 1102-1107.
14. Fouron JC, Teyssier G, Maroto E, Lessard M, Marquette G, (1991) Diastolic circulatory dynamics in the presence of elevated placental resistance and retrograde diastolic flow in the umbilical artery: a Doppler echographic study in lambs. Am J Obstet Gynecol 164: 195-203.
15. Couto PMS, van Meurs WL, Bernardes JF, de Sa JPM, Goodwin JA, (2002) Mathematical model for educational simulation of the oxygen delivery to the fetus. Control Engineering Practice 10: 59-66.
16. Guettouche A, Challier JC, Ito Y, Papapanayotou C, Cherruault Y, et al. (1992) Mathematical modeling of the human fetal arterial blood circulation. Int J Biomed Comput 31: 127-139.
17. Huikeshoven FJ, Hope ID, Power GG, Gilbert RD, Longo LD, (1985) Mathematical model of fetal circulation and oxygen delivery. Am J Physiol 249: R192-202.
18. Menigault E, Berson M, Vieyres P, Lepoivre B, Pourcelot D, et al. (1998) Feto-maternal circulation: mathematical model and comparison with Doppler measurements. Eur J Ultrasound 7: 129-143.
19. Myers LJ, Capper WL, (2002) A transmission line model of the human foetal circulatory system. Medical Engineering & Physics 24: 285-294.
20. Pennati G, Bellotti M, Fumero R, (1997) Mathematical modelling of the human foetal cardiovascular system based on Doppler ultrasound data. Medical Engineering & Physics 19: 327-335.
21. van den Wijngaard JP, Westerhof BE, Faber DJ, Ramsay MM, Westerhof N, et al. (2006) Abnormal arterial flows by a distributed model of the fetal circulation. Am J Physiol Regul Integr Comp Physiol 291: R1222-1233.
22. Garcia-Canadilla P, Rudenick. P., Crispi, F., Cruz-Lemini, M., Palau, G., Gratacos, E., Bijnens, B. H. Understanding Prenatal Brain Sparing by Flow Redistribution Based on a Lumped Model of the Fetal Circulation. Lecture Notes in Computer Science; 2013 June 20-22, 2013; London, UK. Springer Berlin Heidelberg. pp. 123-131.
23. Hadlock FP, Harrist RB, Shah YP, King DE, Park SK, et al. (1987) Estimating fetal age using multiple parameters: a prospective evaluation in a racially mixed population. Am J Obstet Gynecol 156: 955-957.
24. Figueras F, Meler E, Iraola A, Eixarch E, Coll O, et al. (2008) Customized birthweight standards for a Spanish population. Eur J Obstet Gynecol Reprod Biol 136: 20-24.
25. Baschat AA, Gembruch U, (2003) The cerebroplacental Doppler ratio revisited. Ultrasound Obstet Gynecol 21: 124-127.
26. Crispi F, Hernandez-Andrade E, Pelsers MM, Plasencia W, Benavides-Serralde JA, et al. (2008) Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. Am J Obstet Gynecol 199: 254 e251-258.
27. Arduini D, Rizzo G, (1990) Normal values of Pulsatility Index from fetal vessels: a cross-sectional study on 1556 healthy fetuses. J Perinat Med 18: 165-172.
28. Del Rio M, Martinez JM, Figueras F, Lopez M, Palacio M, et al. (2006) Reference ranges for Doppler parameters of the fetal aortic isthmus during the second half of pregnancy. Ultrasound Obstet Gynecol 28: 71-76.
29. Schneider C, McCrindle BW, Carvalho JS, Hornberger LK, McCarthy KP, et al. (2005) Development of Z-scores for fetal cardiac dimensions from echocardiography. Ultrasound Obstet Gynecol 26: 599-605.
30. Ruskamp J, Fouron JC, Gosselin J, Raboisson MJ, Infante-Rivard C, et al. (2003) Reference values for an index of fetal aortic isthmus blood flow during the second half of pregnancy. Ultrasound Obstet Gynecol 21: 441-444.
31. Milisic V, Quarteroni A, (2004) Analysis of lumped parameter models for blood flow simulations and their relation with 1D models. Esaim-Mathematical Modelling and Numerical Analysis-Modelisation Mathematique Et Analyse Numerique 38: 613-632.
32. Shi Y, Lawford P, Hose R, (2011) Review of zero-D and 1-D models of blood flow in the cardiovascular system. Biomed Eng Online 10: 33.
33. Alastruey J, Parker KH, Peiro J, Byrd SM, Sherwin SJ, (2007) Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows. J Biomech 40: 1794-1805.
34. Guettouche A, Papapanayotou C, Cherruault Y, Azancot-Benisty A, Challier JC, (1993) Optimization and resolution algorithm of the human fetal blood circulation model. Math Comput Model 18: 1-8.
35. Nowak D, Kozłowska H, Żurada A, Gielecki J, (2011) The development of the aortic isthmus in human fetal life. Polish Annals of Medicine 18: 42-51.
36. Ruano R, de Fatima Yukie Maeda M, Niigaki JI, Zugaib M, (2007) Pulmonary artery diameters in healthy fetuses from 19 to 40 weeks' gestation. J Ultrasound Med 26: 309-316.
37. Szpinda M, (2007) The normal growth of the thoracic aorta in human foetuses. Folia Morphol (Warsz) 66: 131-137.
38. Szpinda M, (2007) The normal growth of the pulmonary trunk in human foetuses. Folia Morphol (Warsz) 66: 126-130.
39. Szpinda M, (2008) Length growth of the various aortic segments in human foetuses. Folia Morphol (Warsz) 67: 245-250.
40. Szpinda M, Flisinski P, Elminowska-Wenda G, Flisinski M, Krakowiak-Sarnowska E, (2005) The variability and morphometry of the brachiocephalic trunk in human foetuses. Folia Morphol (Warsz) 64: 309-314.
41. Szpinda M, Flisinski P, Szwesta A, Wisniewski M, Dombek M, et al. (2008) Quantitative morphology of the left subclavian artery in human fetuses. Adv Med Sci 53: 69-75.
42. Szpinda M, Flisinski P, Wisniewski M, Dombek M, Krakowiak-Sarnowska E, (2008) Digital-image analysis of the left common carotid artery in human foetuses. Folia Morphol (Warsz) 67: 186-192.
43. Szpinda M, Szpinda A, Wozniak A, Mila-Kierzenkowska C, Kosinski A, et al. (2012) Quantitative anatomy of the growing abdominal aorta in human fetuses: an anatomical, digital and statistical study. Med Sci Monit 18: BR419-426.
44. Szpinda M, Szwesta A, Szpinda E, (2007) Morphometric study of the ductus arteriosus during human development. Ann Anat 189: 47-52.
45. Struijk PC, Mathews VJ, Loupas T, Stewart PA, Clark EB, et al. (2008) Blood pressure estimation in the human fetal descending aorta. Ultrasound Obstet Gynecol 32: 673-681.
46. Kiserud T, (2005) Physiology of the fetal circulation. Semin Fetal Neonatal Med 10: 493-503.
47. Seed M, van Amerom JF, Yoo SJ, Al Nafisi B, Grosse-Wortmann L, et al. (2012) Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson 14: 79.
48. Pennati G, Fumero R, (2000) Scaling approach to study the changes through the gestation of human fetal cardiac and circulatory behaviors. Ann Biomed Eng 28: 442-452.
49. Gallivan S, Robson SC, Chang TC, Vaughan J, Spencer JA, (1993) An investigation of fetal growth using serial ultrasound data. Ultrasound Obstet Gynecol 3: 109-114.
50. Cruz-Martinez R, Figueras F, Hernandez-Andrade E, Oros D, Gratacos E, (2011) Changes in myocardial performance index and aortic isthmus and ductus venosus Doppler in term, small-for-gestational age fetuses with normal umbilical artery pulsatility index. Ultrasound Obstet Gynecol 38: 400-405.
51. Reed KL, Anderson CF, Shenker L, (1987) Changes in intracardiac Doppler blood flow velocities in fetuses with absent umbilical artery diastolic flow. Am J Obstet Gynecol 157: 774-779.
52. Weiner Z, Farmakides G, Schulman H, Penny B, (1994) Central and peripheral hemodynamic changes in fetuses with absent end-diastolic velocity in umbilical artery: correlation with computerized fetal heart rate pattern. Am J Obstet Gynecol 170: 509-515.
53. Akalin-Sel T, Nicolaides KH, Peacock J, Campbell S, (1994) Doppler dynamics and their complex interrelation with fetal oxygen pressure, carbon dioxide pressure, and pH in growth-retarded fetuses. Obstet Gynecol 84: 439-444.