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Volumn 41, Issue 7, 2014, Pages 4507-4512

Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition

Author keywords

EMT; Gallbladder cancer; mTOR; TGF

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VIMENTIN; CADHERIN; IMMUNOSUPPRESSIVE AGENT; MULTIPROTEIN COMPLEX; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

EID: 84903379888     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-014-3321-4     Document Type: Article
Times cited : (76)

References (19)
  • 2
    • 84876543858 scopus 로고    scopus 로고
    • Immunohistochemical expression of phosphomTOR is associated with poor prognosis in patients with gallbladder adenocarcinoma
    • Leal P et al (2013) Immunohistochemical expression of phosphomTOR is associated with poor prognosis in patients with gallbladder adenocarcinoma. Arch Pathol Lab Med 137:552-557
    • (2013) Arch Pathol Lab Med , vol.137 , pp. 552-557
    • Leal, P.1
  • 3
    • 0030981075 scopus 로고    scopus 로고
    • Curative resection in potentially resectable tumours of the gallbladder
    • de Aretxabala XA et al (1997) Curative resection in potentially resectable tumours of the gallbladder. Eur J Surg 163:419-426
    • (1997) Eur J Surg , vol.163 , pp. 419-426
    • De Aretxabala, X.A.1
  • 4
    • 3042606326 scopus 로고    scopus 로고
    • Laparoscopic cholecystectomy: Its effect on the prognosis of patients with gallbladder cancer
    • de Aretxabala XA et al (2004) Laparoscopic cholecystectomy: its effect on the prognosis of patients with gallbladder cancer. World J Surg 28:544-547
    • (2004) World J Surg , vol.28 , pp. 544-547
    • De Aretxabala, X.A.1
  • 5
    • 78649806812 scopus 로고    scopus 로고
    • Chemotherapy in gallbladder carcinoma
    • Abahssain H et al (2010) Chemotherapy in gallbladder carcinoma. Presse Med 39:1238-1245
    • (2010) Presse Med , vol.39 , pp. 1238-1245
    • Abahssain, H.1
  • 6
    • 12544253221 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiotherapy in gallbladder cancer
    • de Aretxabala X et al (2004) Neoadjuvant chemoradiotherapy in gallbladder cancer. Rev Med Chil 132:51-57
    • (2004) Rev Med Chil , vol.132 , pp. 51-57
    • De Aretxabala, X.1
  • 7
    • 0036261550 scopus 로고    scopus 로고
    • Chemotherapy with gemcitabine in patients with gall-bladder carcinoma
    • Rudi J (2002) Chemotherapy with gemcitabine in patients with gall-bladder carcinoma. Ann Oncol 13:807
    • (2002) Ann Oncol , vol.13 , pp. 807
    • Rudi, J.1
  • 8
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420-1428
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 9
    • 84886296996 scopus 로고    scopus 로고
    • Role of the epithelial-mesenchymal transition in bladder cancer: From prognosis to therapeutic target
    • Yun SJ, Kim WJ (2013) Role of the epithelial-mesenchymal transition in bladder cancer: from prognosis to therapeutic target. Korean J Urol 54:645-650
    • (2013) Korean J Urol , vol.54 , pp. 645-650
    • Yun, S.J.1    Kim, W.J.2
  • 10
    • 84885236367 scopus 로고    scopus 로고
    • AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
    • Leal P et al (2013) AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines. Onco Targets Ther 6:1373-1384
    • (2013) Onco Targets Ther , vol.6 , pp. 1373-1384
    • Leal, P.1
  • 12
    • 84885398079 scopus 로고    scopus 로고
    • Combination of rapamycin, CI-1040, and 17-AAG inhibits metastatic capacity of prostate cancer via Slug inhibition
    • Ding G et al (2013) Combination of rapamycin, CI-1040, and 17-AAG inhibits metastatic capacity of prostate cancer via Slug inhibition. PLoS ONE 8:e77400
    • (2013) PLoS ONE , vol.8
    • Ding, G.1
  • 13
    • 84888345142 scopus 로고    scopus 로고
    • Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-beta-independent mechanism
    • Mikaelian I et al (2013) Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-beta-independent mechanism. Cancer Res 73:6621-6631
    • (2013) Cancer Res , vol.73 , pp. 6621-6631
    • Mikaelian, I.1
  • 14
    • 84877713771 scopus 로고    scopus 로고
    • Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2
    • Wen H et al (2013) Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2. Ann Diagn Pathol 17:259-264
    • (2013) Ann Diagn Pathol , vol.17 , pp. 259-264
    • Wen, H.1
  • 15
    • 79955486858 scopus 로고    scopus 로고
    • mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
    • Gulhati P et al (2011) mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71:3246-3256
    • (2011) Cancer Res , vol.71 , pp. 3246-3256
    • Gulhati, P.1
  • 16
    • 33750858427 scopus 로고    scopus 로고
    • Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
    • DOI 10.1038/sj.onc.1209691, PII 1209691
    • Liu L et al (2006) Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 25:7029-7040 (Pubitemid 44722071)
    • (2006) Oncogene , vol.25 , Issue.53 , pp. 7029-7040
    • Liu, L.1    Li, F.2    Cardelli, J.A.3    Martin, K.A.4    Blenis, J.5    Huang, S.6
  • 18
    • 77951229151 scopus 로고    scopus 로고
    • Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1
    • Moss SC, Lightell DJ Jr, Marx SO, Marks AR, Woods TC (2010) Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem 285:11991-11997
    • (2010) J Biol Chem , vol.285 , pp. 11991-11997
    • Moss, S.C.1    Lightell Jr., D.J.2    Marx, S.O.3    Marks, A.R.4    Woods, T.C.5
  • 19
    • 84861448736 scopus 로고    scopus 로고
    • TGF-beta-induced activation of mTOR complex 2 drives epithelial- mesenchymal transition and cell invasion
    • Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R (2012) TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci 125:1259-1273
    • (2012) J Cell Sci , vol.125 , pp. 1259-1273
    • Lamouille, S.1    Connolly, E.2    Smyth, J.W.3    Akhurst, R.J.4    Derynck, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.