메뉴 건너뛰기




Volumn 6, Issue , 2013, Pages 1373-1384

AKT/mTOR substrate p70S6k is frequently phosphorylated in gallbladder cancer tissue and cell lines

Author keywords

AKT; Cell line; Gallbladder cancer; Migration; mTOR inhibitor; p70s6k

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AZD 8055; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN P70S6K; RAPAMYCIN; UNCLASSIFIED DRUG;

EID: 84885236367     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S46897     Document Type: Article
Times cited : (33)

References (59)
  • 1
    • 0035572863 scopus 로고    scopus 로고
    • Epidemiology and molecular pathology of gallbladder cancer
    • Lazcano-Ponce EC, Miquel JF, Munoz N, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 2001;51: 349-364.
    • (2001) CA Cancer J Clin , vol.51 , pp. 349-364
    • Lazcano-Ponce, E.C.1    Miquel, J.F.2    Munoz, N.3
  • 2
    • 33644848963 scopus 로고    scopus 로고
    • Gallbladder cancer worldwide: Geographical distribution and risk factors
    • Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118: 1591-1602.
    • (2006) Int J Cancer , vol.118 , pp. 1591-1602
    • Randi, G.1    Franceschi, S.2    la Vecchia, C.3
  • 3
    • 0036139720 scopus 로고    scopus 로고
    • Adjuvant external beam radiation therapy with concurrent chemotherapy in the management of gallbladder carcinoma
    • Kresl JJ, Schild SE, Henning GT, et al. Adjuvant external beam radiation therapy with concurrent chemotherapy in the management of gallbladder carcinoma. Int J Radiat Oncol Biol Phys. 2002;52:167-175.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 167-175
    • Kresl, J.J.1    Schild, S.E.2    Henning, G.T.3
  • 4
    • 0037392970 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin is a highly effective combination chemotherapy in patients with advanced cancer of the gallbladder
    • Malik IA, Aziz Z, Zaidi SH, Sethuraman G. Gemcitabine and cisplatin is a highly effective combination chemotherapy in patients with advanced cancer of the gallbladder. Am J Clin Oncol. 2003;26:174-177.
    • (2003) Am J Clin Oncol , vol.26 , pp. 174-177
    • Malik, I.A.1    Aziz, Z.2    Zaidi, S.H.3    Sethuraman, G.4
  • 6
    • 77950822827 scopus 로고    scopus 로고
    • Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer
    • Valle J, Wasan H, Palmer DH, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010;362: 1273-1281.
    • (2010) N Engl J Med , vol.362 , pp. 1273-1281
    • Valle, J.1    Wasan, H.2    Palmer, D.H.3
  • 8
  • 10
    • 77955293298 scopus 로고    scopus 로고
    • Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: A Phase II Consortium study
    • Lubner SJ, Mahoney MR, Kolesar JL, et al. Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a Phase II Consortium study. J Clin Oncol. 2010;28:3491-3497.
    • (2010) J Clin Oncol , vol.28 , pp. 3491-3497
    • Lubner, S.J.1    Mahoney, M.R.2    Kolesar, J.L.3
  • 11
    • 73249128451 scopus 로고    scopus 로고
    • Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: A phase 2study
    • Zhu AX, Meyerhardt JA, Blaszkowsky LS, et al. Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2study. Lancet Oncol. 2010;11:48-54.
    • (2010) Lancet Oncol , vol.11 , pp. 48-54
    • Zhu, A.X.1    Meyerhardt, J.A.2    Blaszkowsky, L.S.3
  • 12
    • 74249098818 scopus 로고    scopus 로고
    • Sorafenib in patients with advanced biliary tract carcinoma: A phase II trial
    • Bengala C, Bertolini F, Malavasi N, et al. Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial. Br J Cancer. 2010;102: 68-72.
    • (2010) Br J Cancer , vol.102 , pp. 68-72
    • Bengala, C.1    Bertolini, F.2    Malavasi, N.3
  • 13
    • 84856294957 scopus 로고    scopus 로고
    • Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101
    • Chiorean EG, Ramasubbaiah R, Yu M, et al. Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101. Oncologist. 2012;17:13.
    • (2012) Oncologist , vol.17 , pp. 13
    • Chiorean, E.G.1    Ramasubbaiah, R.2    Yu, M.3
  • 14
    • 84856476387 scopus 로고    scopus 로고
    • Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: A multicentre, openlabel, randomised, phase 3study
    • Lee J, Park SH, Chang HM, et al. Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, openlabel, randomised, phase 3study. Lancet Oncol. 2012;13:181-188.
    • (2012) Lancet Oncol , vol.13 , pp. 181-188
    • Lee, J.1    Park, S.H.2    Chang, H.M.3
  • 15
    • 78649581706 scopus 로고    scopus 로고
    • Cetuximab, gemcitabine, and oxaliplatin in patients with unresectable advanced or metastatic biliary tract cancer: A phase 2study
    • Gruenberger B, Schueller J, Heubrandtner U, et al. Cetuximab, gemcitabine, and oxaliplatin in patients with unresectable advanced or metastatic biliary tract cancer: a phase 2study. Lancet Oncol. 2010;11: 1142-1148.
    • (2010) Lancet Oncol , vol.11 , pp. 1142-1148
    • Gruenberger, B.1    Schueller, J.2    Heubrandtner, U.3
  • 16
    • 84876543858 scopus 로고    scopus 로고
    • Immunohistochemical expression of phospho-mTOR is associated with poor prognosis in patients with gall-bladder adenocarcinoma
    • Leal P, Garcia P, Sandoval A, et al. Immunohistochemical expression of phospho-mTOR is associated with poor prognosis in patients with gall-bladder adenocarcinoma. Arch Pathol Lab Med. 2013;137:552-557.
    • (2013) Arch Pathol Lab Med , vol.137 , pp. 552-557
    • Leal, P.1    Garcia, P.2    Sandoval, A.3
  • 17
    • 34248580938 scopus 로고    scopus 로고
    • Therapeutic effect of rapamy-cin on gallbladder cancer in a transgenic mouse model
    • Wu Q, Kiguchi K, Kawamoto T, et al. Therapeutic effect of rapamy-cin on gallbladder cancer in a transgenic mouse model. Cancer Res. 2007;67:3794-3800.
    • (2007) Cancer Res , vol.67 , pp. 3794-3800
    • Wu, Q.1    Kiguchi, K.2    Kawamoto, T.3
  • 19
    • 84885210066 scopus 로고    scopus 로고
    • MK2206 in Treating Patients With Advanced Refractory Biliary Cancer That Cannot Be Removed by Surgery
    • National Cancer Institute In, [website on the Internet]. Bethesda, MD: US National Library of Medicine, [updated May 28, 2013]. Available from: NLM identifier: NCT01425879. Accessed August 28, 2013
    • National Cancer Institute. MK2206 in Treating Patients With Advanced Refractory Biliary Cancer That Cannot Be Removed by Surgery. In: ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011 [updated May 28, 2013]. Available from: http://clinicaltrials.gov/show/NCT01425879. NLM identifier: NCT01425879. Accessed August 28, 2013.
    • (2011) ClinicalTrials.gov
  • 20
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin DA, Sabatini DM. The pharmacology of mTOR inhibition. Sci Signal. 2009;2:pe24.
    • (2009) Sci Signal , vol.2 , pp. 24
    • Guertin, D.A.1    Sabatini, D.M.2
  • 22
    • 77949452524 scopus 로고    scopus 로고
    • The PKB/AKT pathway in cancer
    • Carnero A. The PKB/AKT pathway in cancer. Curr Pharm Des. 2010;16:34-44.
    • (2010) Curr Pharm Des , vol.16 , pp. 34-44
    • Carnero, A.1
  • 23
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 24
    • 84862772241 scopus 로고    scopus 로고
    • p70S6 kinase phosphorylation for pharmacodynamic monitoring
    • Hartmann B. p70S6 kinase phosphorylation for pharmacodynamic monitoring. Clin Chim Acta. 2012;413:1387-1390.
    • (2012) Clin Chim Acta , vol.413 , pp. 1387-1390
    • Hartmann, B.1
  • 25
    • 4143111260 scopus 로고    scopus 로고
    • AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    • Altomare DA, Wang HQ, Skele KL, et al. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. 2004;23:5853-5857.
    • (2004) Oncogene , vol.23 , pp. 5853-5857
    • Altomare, D.A.1    Wang, H.Q.2    Skele, K.L.3
  • 26
    • 4043050174 scopus 로고    scopus 로고
    • G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/ p70S6K1signaling in human ovarian cancer cells
    • Gao N, Flynn DC, Zhang Z, et al. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/ p70S6K1signaling in human ovarian cancer cells. Am J Physiol Cell Physiol. 2004;287:C281-C291.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Gao, N.1    Flynn, D.C.2    Zhang, Z.3
  • 27
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • Gao N, Zhang Z, Jiang BH, Shi X. Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun. 2003;310:1124-1132.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 1124-1132
    • Gao, N.1    Zhang, Z.2    Jiang, B.H.3    Shi, X.4
  • 28
    • 33750285711 scopus 로고    scopus 로고
    • Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
    • Meng Q, Xia C, Fang J, Rojanasakul Y, Jiang BH. Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. Cell Signal. 2006;18: 2262-2271.
    • (2006) Cell Signal , vol.18 , pp. 2262-2271
    • Meng, Q.1    Xia, C.2    Fang, J.3    Rojanasakul, Y.4    Jiang, B.H.5
  • 29
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • Zhou X, Tan M, Stone Hawthorne V, et al. Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res. 2004;10:6779-6788.
    • (2004) Clin Cancer Res , vol.10 , pp. 6779-6788
    • Zhou, X.1    Tan, M.2    Stone Hawthorne, V.3
  • 30
    • 84869162108 scopus 로고    scopus 로고
    • Everolimus and its role in hormoneresistant and trastuzumab-resistant metastatic breast cancer
    • Keck S, Glencer AC, Rugo HS. Everolimus and its role in hormoneresistant and trastuzumab-resistant metastatic breast cancer. Future Oncol. 2012;8:1383-1396.
    • (2012) Future Oncol , vol.8 , pp. 1383-1396
    • Keck, S.1    Glencer, A.C.2    Rugo, H.S.3
  • 31
    • 34547130295 scopus 로고    scopus 로고
    • RAD001inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model
    • Mabuchi S, Altomare DA, Cheung M, et al. RAD001inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res. 2007;13:4261-4270.
    • (2007) Clin Cancer Res , vol.13 , pp. 4261-4270
    • Mabuchi, S.1    Altomare, D.A.2    Cheung, M.3
  • 32
    • 84862543359 scopus 로고    scopus 로고
    • Combination of RAD001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells
    • Tai S, Sun Y, Liu N, et al. Combination of RAD001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. Mol Cancer Ther. 2012;11: 1320-1331.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1320-1331
    • Tai, S.1    Sun, Y.2    Liu, N.3
  • 34
    • 84866648354 scopus 로고    scopus 로고
    • mTOR inhibition, the second generation: ATP-competitive mTOR inhibitor initiates unexpected receptor tyrosine kinase-driven feedback loop
    • Keniry M, Parsons R. mTOR inhibition, the second generation: ATP-competitive mTOR inhibitor initiates unexpected receptor tyrosine kinase-driven feedback loop. Cancer Discov. 2011;1:203-204.
    • (2011) Cancer Discov , vol.1 , pp. 203-204
    • Keniry, M.1    Parsons, R.2
  • 35
    • 75149112670 scopus 로고    scopus 로고
    • AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
    • Chresta CM, Davies BR, Hickson I, et al. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 2010;70:288-298.
    • (2010) Cancer Res , vol.70 , pp. 288-298
    • Chresta, C.M.1    Davies, B.R.2    Hickson, I.3
  • 36
    • 84872714173 scopus 로고    scopus 로고
    • Combined inhibition of mTORC1 and mTORC2signaling pathways is a promising therapeutic option in inhibiting pheochromocytoma tumor growth: In vitro and in vivo studies in female athymic nude mice
    • Giubellino A, Bullova P, Nolting S, et al. Combined inhibition of mTORC1 and mTORC2signaling pathways is a promising therapeutic option in inhibiting pheochromocytoma tumor growth: in vitro and in vivo studies in female athymic nude mice. Endocrinology. 2013;154: 646-655.
    • (2013) Endocrinology , vol.154 , pp. 646-655
    • Giubellino, A.1    Bullova, P.2    Nolting, S.3
  • 37
    • 84859412782 scopus 로고    scopus 로고
    • Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055)
    • Holt SV, Logie A, Davies BR, et al. Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055). Cancer Res. 2012;72: 1804-1813.
    • (2012) Cancer Res , vol.72 , pp. 1804-1813
    • Holt, S.V.1    Logie, A.2    Davies, B.R.3
  • 38
    • 77953703298 scopus 로고    scopus 로고
    • Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055induces autophagy and cell death in cancer cells
    • Sini P, James D, Chresta C, Guichard S. Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055induces autophagy and cell death in cancer cells. Autophagy. 2010;6: 553-554.
    • (2010) Autophagy , vol.6 , pp. 553-554
    • Sini, P.1    James, D.2    Chresta, C.3    Guichard, S.4
  • 39
    • 84874670919 scopus 로고    scopus 로고
    • Connective tissue growth factor immunohistochemical expression is associated with gallbladder cancer progression
    • Garcia P, Leal P, Alvarez H, et al. Connective tissue growth factor immunohistochemical expression is associated with gallbladder cancer progression. Arch Pathol Lab Med. 2013;137:245-250.
    • (2013) Arch Pathol Lab Med , vol.137 , pp. 245-250
    • Garcia, P.1    Leal, P.2    Alvarez, H.3
  • 40
    • 77957352037 scopus 로고    scopus 로고
    • PTEN, PIK3CA, p-AKT, and p-p70S6K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer
    • Esteva FJ, Guo H, Zhang S, et al. PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol. 2010;177:1647-1656.
    • (2010) Am J Pathol , vol.177 , pp. 1647-1656
    • Esteva, F.J.1    Guo, H.2    Zhang, S.3
  • 41
    • 50049129087 scopus 로고    scopus 로고
    • Oestrogen receptor status of breast carcinoma: Allred/H score conversion table
    • Shousha S. Oestrogen receptor status of breast carcinoma: Allred/H score conversion table. Histopathology. 2008;53:346-347.
    • (2008) Histopathology , vol.53 , pp. 346-347
    • Shousha, S.1
  • 42
    • 70350418625 scopus 로고    scopus 로고
    • mTOR signaling at a glance
    • Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci. 2009;122:3589-3594.
    • (2009) J Cell Sci , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 43
    • 70049113978 scopus 로고    scopus 로고
    • Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics
    • Dai B, Kong YY, Ye DW, et al. Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics. BJU Int. 2009;104: 1009-1016.
    • (2009) BJU Int , vol.104 , pp. 1009-1016
    • Dai, B.1    Kong, Y.Y.2    Ye, D.W.3
  • 44
    • 79956196878 scopus 로고    scopus 로고
    • Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 protein
    • Egervari G, Mark A, Hajdu M, et al. Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 protein. Histochem Cell Biol. 2011;135:409-417.
    • (2011) Histochem Cell Biol , vol.135 , pp. 409-417
    • Egervari, G.1    Mark, A.2    Hajdu, M.3
  • 45
    • 48849086912 scopus 로고    scopus 로고
    • Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
    • Heinonen H, Nieminen A, Saarela M, et al. Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer. BMC Genomics. 2008;9:348.
    • (2008) BMC Genomics , vol.9 , pp. 348
    • Heinonen, H.1    Nieminen, A.2    Saarela, M.3
  • 46
    • 33947099498 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model
    • Lang SA, Gaumann A, Koehl GE, et al. Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model. Int J Cancer. 2007;120:1803-1810.
    • (2007) Int J Cancer , vol.120 , pp. 1803-1810
    • Lang, S.A.1    Gaumann, A.2    Koehl, G.E.3
  • 47
    • 0037295455 scopus 로고    scopus 로고
    • Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues
    • Miyakawa M, Tsushima T, Murakami H, et al. Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues. Endocr J. 2003;50:77-83.
    • (2003) Endocr J , vol.50 , pp. 77-83
    • Miyakawa, M.1    Tsushima, T.2    Murakami, H.3
  • 48
    • 79952818313 scopus 로고    scopus 로고
    • Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer
    • No JH, Jeon YT, Park IA, et al. Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer. Gynecol Oncol. 2011;121:8-12.
    • (2011) Gynecol Oncol , vol.121 , pp. 8-12
    • No, J.H.1    Jeon, Y.T.2    Park, I.A.3
  • 49
    • 84863833291 scopus 로고    scopus 로고
    • Immunohistochemical analysis of the mTOR pathway in intrahepatic cholangiocarcinoma
    • Wang Z, Zheng T, Wu Q, Wang J, Wu C. Immunohistochemical analysis of the mTOR pathway in intrahepatic cholangiocarcinoma. Neoplasma. 2012;59:137-141.
    • (2012) Neoplasma , vol.59 , pp. 137-141
    • Wang, Z.1    Zheng, T.2    Wu, Q.3    Wang, J.4    Wu, C.5
  • 50
    • 74949110996 scopus 로고    scopus 로고
    • The role of mTOR and phosphop70S6K in pathogenesis and progression of gastric carcinomas: An immunohistochemical study on tissue microarray
    • Xiao L, Wang YC, Li WS, Du Y. The role of mTOR and phosphop70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray. J Exp Clin Cancer Res. 2009;28:152.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 152
    • Xiao, L.1    Wang, Y.C.2    Li, W.S.3    Du, Y.4
  • 51
    • 33645856178 scopus 로고    scopus 로고
    • Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor mediated invasion in human ovarian cancer cells
    • Zhou HY, Wong AS. Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor mediated invasion in human ovarian cancer cells. Endocrinology. 2006;147:2557-2566.
    • (2006) Endocrinology , vol.147 , pp. 2557-2566
    • Zhou, H.Y.1    Wong, A.S.2
  • 52
    • 45849084692 scopus 로고    scopus 로고
    • Constitutive activation of p70S6 kinase is associated with intrinsic resistance to cisplatin
    • Dhar R, Basu A. Constitutive activation of p70S6 kinase is associated with intrinsic resistance to cisplatin. Int J Oncol. 2008;32: 1133-1137.
    • (2008) Int J Oncol , vol.32 , pp. 1133-1137
    • Dhar, R.1    Basu, A.2
  • 53
    • 79151470770 scopus 로고    scopus 로고
    • Phosphorylated S6K1 is a possible marker for endocrine therapy resistance in hormone receptor-positive breast cancer
    • Kim EK, Kim HA, Koh JS, et al. Phosphorylated S6K1 is a possible marker for endocrine therapy resistance in hormone receptor-positive breast cancer. Breast Cancer Res Treat. 2011;126:93-99.
    • (2011) Breast Cancer Res Treat , vol.126 , pp. 93-99
    • Kim, E.K.1    Kim, H.A.2    Koh, J.S.3
  • 54
    • 34447125097 scopus 로고    scopus 로고
    • AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway
    • Liu LZ, Zhou XD, Qian G, et al. AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. Cancer Res. 2007;67:6325-6332.
    • (2007) Cancer Res , vol.67 , pp. 6325-6332
    • Liu, L.Z.1    Zhou, X.D.2    Qian, G.3
  • 55
    • 84855351685 scopus 로고    scopus 로고
    • The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas
    • Lee D, Do IG, Choi K, et al. The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. Mod Pathol. 2012;25:131-139.
    • (2012) Mod Pathol , vol.25 , pp. 131-139
    • Lee, D.1    Do, I.G.2    Choi, K.3
  • 56
    • 0018941550 scopus 로고
    • Establishment of a cell line (G-415) from a human gallbladder carcinoma
    • Koyama S, Yoshioka T, Mizushima A, et al. Establishment of a cell line (G-415) from a human gallbladder carcinoma. Gann. 1980;71:574-575.
    • (1980) Gann , vol.71 , pp. 574-575
    • Koyama, S.1    Yoshioka, T.2    Mizushima, A.3
  • 57
    • 4544295901 scopus 로고    scopus 로고
    • Establishment and characterization of unique human gallbladder cancer cell lines
    • Ghosh M, Koike N, Yanagimoto G, et al. Establishment and characterization of unique human gallbladder cancer cell lines. Int J Oncol. 2004;24:1189-1196.
    • (2004) Int J Oncol , vol.24 , pp. 1189-1196
    • Ghosh, M.1    Koike, N.2    Yanagimoto, G.3
  • 58
    • 79957599658 scopus 로고    scopus 로고
    • p70S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells
    • Ip CK, Cheung AN, Ngan HY, Wong AS. p70S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene. 2011;30:2420-2432.
    • (2011) Oncogene , vol.30 , pp. 2420-2432
    • Ip, C.K.1    Cheung, A.N.2    Ngan, H.Y.3    Wong, A.S.4
  • 59
    • 84876726023 scopus 로고    scopus 로고
    • First-in-human phase I study of LY2780301, an oral P70S6K/AKT inhibitor, in patients with refractory solid tumors
    • Abstr 3005
    • Calvo et al. First-in-human phase I study of LY2780301, an oral P70S6K/AKT inhibitor, in patients with refractory solid tumors. J Clin Oncol. 2012;30 Suppl:Abstr 3005.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Calvo1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.