Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C-induced degradation

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 25, 2014, Pages 5932-5938

  Liao, Jiahn Haur ^a   Lin, I Lin ^b   Huang, Kai Fa ^a   Kuo, Pei Ting ^b   Wu, Shih Hsiung ^a   Wu, Tzu Hua ^b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

calpain proteolysis; carnosine; lens turbidity; molecular modeling; UV insults

Indexed keywords

IRRADIATION; MOLECULAR MODELING; PROTEINS; PROTEOLYSIS;

CALPAINS; CARNOSINE; CATARACT FORMATION; DIFFERENTIAL EFFECT; IN-VITRO MODELS; ULTRAVIOLET IRRADIATIONS; UV INSULTS; UV-B IRRADIATIONS; INDUCED DEGRADATION;

TURBIDITY;

SUS;

CALPAIN; CALPASTATIN; CARNOSINE; CRYSTALLIN; GLYCOPROTEIN;

AMINO ACID SEQUENCE; ANIMAL; CATARACT; CHEMISTRY; GENETICS; HUMAN; LENS; METABOLISM; MOLECULAR GENETICS; PROTEIN DEGRADATION; RADIATION RESPONSE; SEQUENCE ALIGNMENT; SWINE; ULTRAVIOLET RADIATION;

AMINO ACID SEQUENCE; ANIMALS; CALPAIN; CARNOSINE; CATARACT; CRYSTALLINS; GLYCOPROTEINS; HUMANS; LENS, CRYSTALLINE; MOLECULAR SEQUENCE DATA; PROTEOLYSIS; SEQUENCE ALIGNMENT; SWINE; ULTRAVIOLET RAYS;

EID: 84903291698     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf5017708     Document Type: Article

References (39)

1. Boldyrev, A. A.; Aldini, G.; Derave, W. Physiology and pathophysiology of carnosine Physiol. Rev. 2013, 93, 1803-1845
2. Quinn, P. J.; Boldyrev, A. A.; Formazuyk, V. E. Carnosine: its properties, functions and potential therapeutic applications Mol. Aspects Med. 1992, 13, 379-444
3. Babizhayev, M. A. Antioxidant activity of l -carnosine, a natural histidine-containing dipeptide in crystalline lens Biochim. Biophys. Acta 1989, 1004, 363-371
4. Babizhayev, M. A.; Seguin, M. C.; Gueyne, J.; Evstigneeva, R. P.; Ageyeva, E. A.; Zheltukhina, G. A. l -Carnosine (β-alanyl- l -histidine) and carcinine (β-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities Biochem. J. 1994, 304 (Part 2) 509-516
5. Hipkiss, A. R.; Brownson, C.; Carrier, M. J. Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups Mech. Ageing Dev. 2001, 122, 1431-1445
6. Attanasio, F.; Cataldo, S.; Fisichella, S.; Nicoletti, S.; Nicoletti, V. G.; Pignataro, B.; Savarino, A.; Rizzarelli, E. Protective effects of l-and d -carnosine on α-crystallin amyloid fibril formation: implications for cataract disease Biochemistry 2009, 48, 6522-6531
7. Seidler, N. W.; Yeargans, G. S.; Morgan, T. G. Carnosine disaggregates glycated α-crystallin: an in vitro study Arch. Biochem. Biophys. 2004, 427, 110-115
8. Yan, H.; Harding, J. J. Carnosine inhibits modifications and decreased molecular chaperone activity of lens α-crystallin induced by ribose and fructose 6-phosphate Mol. Vis. 2006, 12, 205-214
9. Biswas, S.; Harris, F.; Dennison, S.; Singh, J.; Phoenix, D. A. Calpains: targets of cataract prevention? Trends Mol. Med. 2004, 10, 78-84
10. David, L. L.; Shearer, T. R. Purification of calpain II from rat lens and determination of endogenous substrates Exp. Eye Res. 1986, 42, 227-238
11. Andersson, M.; Sjostrand, J.; Andersson, A. K.; Andersen, B.; Karlsson, J. O. Calpains in lens epithelium from patients with cataract Exp. Eye Res. 1994, 59, 359-364
12. 2+-induced protein loss, vimentin cleavage and opacification Invest. Ophthalmol. Vis. Sci. 2000, 41, 2255-2261
13. Carragher, N. O. Calpain inhibition: a therapeutic strategy targeting multiple disease states Curr. Pharm. Des. 2006, 12, 615-638
14. Hollows, F.; Moran, D. Cataract-the ultraviolet risk factor Lancet 1981, 2, 1249-1250
15. Taylor, H. R.; West, S. K.; Rosenthal, F. S.; Munoz, B.; Newland, H. S.; Abbey, H.; Emmett, E. A. Effect of ultraviolet radiation on cataract formation N. Engl. J. Med. 1988, 319, 1429-1433
16. Sommerburg, O.; Ullrich, O.; Sitte, N.; von Zglinicki, D.; Siems, W.; Grune, T. Dose- and wavelength-dependent oxidation of crystallins by UV light-selective recognition and degradation by the 20S proteasome Free Radical Biol. Med. 1998, 24, 1369-1374
17. Fujii, N.; Uchida, H.; Saito, T. The damaging effect of UV-C irradiation on lens α-crystallin Mol. Vis. 2004, 10, 814-820
18. Hu, C.-C.; Liao, J.-H.; Hsu, K.-Y.; Lin, I. L.; Tsai, M.-H.; Wu, W.-H.; Wei, T.-T.; Huang, Y.-S.; Chiu, S.-J.; Chen, H.-Y.; Wu, S.-H.; Wu, T.-H. Role of pirenoxine in the effects of catalin on in vitro ultraviolet-induced lens protein turbidity and selenite-induced cataractogenesis in vivo Mol. Vis. 2011, 17, 1862-1870
19. Liao, J.-H.; Wu, T.-H.; Hsu, F.-L.; Huang, Y.-S.; Chiang, P.-H.; Huang, Z.-Y.; Huang, C.-H.; Wu, S.-H.; Lin, M.-H. Anti-UVC irradiation and metal chelation properties of 6-benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: an implications for anti-cataract agent Int. J. Mol. Sci. 2011, 12, 7059-7076
20. Liao, J.-H.; Chen, C.-S.; Hu, C.-C.; Chen, W.-T.; Wang, S.-P.; Lin, I. L.; Huang, Y.-H.; Tsai, M.-H.; Wu, T.-H.; Huang, F.-Y.; Wu, S.-H. Ditopic complexation of selenite anions or calcium cations by pirenoxine: an implication for anti-cataractogenesis Inorg. Chem. 2011, 50, 365-377
21. 2+ complex formation in the deceleration of cis/trans isomerization Org. Lett. 2007, 9, 2985-2988
22. Wu, T.-H.; Liao, J.-H.; Hou, W.-C.; Huang, F.-Y.; Maher, T. J.; Hu, C.-C. Astaxanthin protects against oxidative stress and calcium-induced porcine lens protein degradation J. Agric. Food Chem. 2006, 54, 2418-2423
23. Babizhayev, M. A.; Deyev, A. I.; Yermakova, V. N.; Semiletov, Y. A.; Davydova, N. G.; Kurysheva, N. I.; Zhukotskii, A. V.; Goldman, I. M. N -Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts Peptides 2001, 22, 979-994
24. Babizhayev, M. A.; Khoroshilova-Maslova, I. P.; Kasus-Jacobi, A. Novel intraocular and systemic absorption drug delivery and efficacy of N -acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care Fundam. Clin. Pharmacol. 2012, 26, 644-678
25. Dizhevskaya, A. K.; Muranov, K. O.; Boldyrev, A. A.; Ostrovsky, M. A. Natural dipeptides as mini-chaperones: molecular mechanism of inhibition of lens β- l -crystallin aggregation Curr. Aging Sci. 2012, 5, 236-241
26. Liao, J.-H.; Lee, J.-S.; Chiou, S.-H. C-terminal lysine truncation increases thermostability and enhances chaperone-like function of porcine αB-crystallin Biochem. Biophys. Res. Commun. 2002, 297, 309-316
27. Shih, M.; David, L. L.; Lampi, K. J.; Ma, H.; Fukiage, C.; Azuma, M.; Shearer, T. R. Proteolysis by m-calpain enhances in vitro light scattering by crystallins from human and bovine lenses Curr. Eye Res. 2001, 22, 458-469
28. Liao, J. H.; Lee, J. S.; Chiou, S. H. Distinct roles of αA- and αB-crystallins under thermal and UV stresses Biochem. Biophys. Res. Commun. 2002, 295, 854-861
29. Andley, U. P.; Clark, B. A. Spectroscopic studies on the photooxidation of calf-lens γ-crystallin Curr. Eye Res. 1988, 7, 571-579
30. Hanna, R. A.; Campbell, R. L.; Davies, P. L. Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin Nature 2008, 456, 409-412
31. David, L. L.; Shearer, T. R. β-Crystallins insolubilized by calpain II in vitro contain cleavage sites similar to β-crystallins insolubilized during cataract FEBS Lett. 1993, 324, 265-270
32. 13C NMR relaxation investigation of the calcium complex of β-alanyl- l -histidine (carnosine) in aqueous solution J. Chem. Soc., Perkin Trans. 2 1990, 401-406
33. Brow, C. E. Chelation chemistry of carnosine. Evidence that mixed complexes may occur in vivo J. Phys. Chem. 1979, 83, 3314-3319
34. Babizhayev, M. A.; Yermakova, V. N.; Semiletov, Y. A.; Deyev, A. I. The natural histidine-containing dipeptide α-acetylcarnosine as an antioxidant for ophthalmic use Biochemistry (Moscow) 2000, 65, 588-598
35. Aristoy, M.-C. n.; Soler, C.; Toldrá, F. A simple, fast and reliable methodology for the analysis of histidine dipeptides as markers of the presence of animal origin proteins in feeds for ruminants Food Chem. 2004, 84, 485-491
36. Andley, U. P.; Clark, B. A. Generation of oxidants in the near-UV photooxidation of human lens α-crystallin Invest. Ophthalmol. Vis. Sci. 1989, 30, 706-713
37. Wu, K.; Kojima, M.; Shui, Y. B.; Sasaki, K.; Hockwin, O. In vitro UV-B effect on lens protein solutions Ophthalmic Res. 1997, 29, 75-82
38. Wang, S. S. S.; Wen, W.-S. Examining the influence of ultraviolet C irradiation on recombinant human γ- d -crystallin Mol. Vis. 2010, 16, 2777-2790
39. Yan, H.; Guo, Y.; Zhang, J.; Ding, Z.; Ha, W.; Harding, J. J. Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats Mol. Vis. 2008, 14, 2282-2291