Oral delivery of paclitaxel nanocrystal (PNC) with a dual Pgp-CYP3A4 inhibitor: Preparation, characterization and antitumor activity

International Journal of Pharmaceutics

Volumn 472, Issue 1-2, 2014, Pages 214-223

  Patel, Ketan ^a   Patil, Anand ^b   Mehta, Miten ^b   Gota, Vikram ^b   Vavia, Pradeep ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b TATA MEMORIAL HOSPITAL   (India)

Author keywords

Cationic nanoparticles; Nanosuspension; Oral anticancer; Oral delivery; Paclitaxel; Pgp inhibitors

Indexed keywords

ARGININE; CLARITHROMYCIN; CYCLOSPORIN A; NANOCRYSTAL; PACLITAXEL; SURFACTANT; ANTINEOPLASTIC AGENT; CYCLOSPORIN; CYTOCHROME P450 3A INHIBITOR; HYDROXYPROPYLMETHYLCELLULOSE; MULTIDRUG RESISTANCE PROTEIN; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENTIATION; DRUG SOLUBILITY; MELANOMA; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; SURFACE CHARGE; SURFACE PROPERTY; TUMOR MODEL; TUMOR VOLUME; TUMOR XENOGRAFT; X RAY DIFFRACTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CHEMISTRY; CHICKEN; DRUG EFFECTS; GASTROINTESTINAL TRACT; ILEUM; MELANOMA, EXPERIMENTAL; METABOLISM; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; PATHOLOGY; SKIN NEOPLASMS; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARGININE; CHICKENS; CLARITHROMYCIN; CYCLOSPORINE; CYTOCHROME P-450 CYP3A INHIBITORS; DRUG COMPOUNDING; GASTROINTESTINAL TRACT; HYPROMELLOSE DERIVATIVES; ILEUM; MELANOMA, EXPERIMENTAL; MICE; NANOPARTICLES; P-GLYCOPROTEIN; PACLITAXEL; PARTICLE SIZE; RATS, SPRAGUE-DAWLEY; SKIN NEOPLASMS; SURFACE PROPERTIES; TUMOR BURDEN;

EID: 84903287440     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.06.031     Document Type: Article

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