Effect of Rikkunshito on the expression of substance P and CGRP in dorsal root ganglion neurons and voluntary movement in rats with experimental reflux esophagitis

Neurogastroenterology and Motility

Volumn 26, Issue 7, 2014, Pages 913-921

  Kondo, T ^a   Oshima, T ^a   Koseki, J ^b   Hattori, T ^b   Kase, Y ^b   Tomita, T ^a   Fukui, H ^a   Watari, J ^a   Miwa, H ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b TSUMURA AND CO   (Japan)

Author keywords

CGRP; DRG; ERK1 2; Rikkunshito; SP

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CHROMIC ACID; HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OMEPRAZOLE; RIKKUNSHITO; SUBSTANCE P; UNCLASSIFIED DRUG; LIU-JUN-ZI-TANG; PROTON PUMP INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DYSPEPSIA; ESOPHAGUS INJURY; ESOPHAGUS MUCOSA; GENE EXPRESSION; HERBAL MEDICINE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFRARED SENSOR; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REFLUX ESOPHAGITIS; SENSOR; SENSORY NERVE; SPINAL GANGLION; VOLUNTARY MOVEMENT; WISTAR RAT; ANIMAL; DISEASE MODEL; DRUG EFFECTS; ESOPHAGITIS, PEPTIC; METABOLISM; MOVEMENT (PHYSIOLOGY); NERVE CELL; PATHOPHYSIOLOGY;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; ESOPHAGITIS, PEPTIC; GANGLIA, SPINAL; MALE; MOVEMENT; NEURONS; OMEPRAZOLE; PROTON PUMP INHIBITORS; RATS; RATS, WISTAR; SUBSTANCE P;

EID: 84903278802     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12342     Document Type: Article

References (49)

1. Tominaga K, Iwakiri R, Fujimoto K, Fujiwara Y, Tanaka M, Shimoyama Y, Umegaki E, Higuchi K et al. Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan. J Gastroenterol 2012; 47: 284-92.
2. Kawahara H, Kubota A, Hasegawa T, Okuyama H, Ueno T, Ida S, Fukuzawa M. Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux. Pediatr Surg Int 2007; 23: 1001-5.
3. Hiyama T, Yoshihara M, Tanaka S, Haruma K, Chayama K. Strategy for treatment of nonerosive reflux disease in Asia. World J Gastroenterol 2008; 14: 3123-8.
4. Tatsuta M, Iishi H. Effect of treatment with liu-jun-zi-tang (TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients. Aliment Pharmacol Ther 1993; 7: 459-62.
5. Yanai M, Mochiki E, Ogawa A, Morita H, Toyomasu Y, Ogata K, Tabe Y, Ando H et al. Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs. J Gastroenterol 2013; 48: 611-9.
6. Tominaga K, Arakawa T. Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application. J Gastroenterol 2013; 48: 452-62.
7. Hayakawa T, Arakawa T, Kase Y, Akiyama S, Ishige A, Takeda S, Sasaki H, Uno H et al. Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs. Drugs Exp Clin Res 1999; 25: 211-8.
8. Kido T, Nakai Y, Kase Y, Sakakibara I, Nomura M, Takeda S, Aburada M. Effects of rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by N(G)-nitro-L-arginine. J Pharmacol Sci 2005; 98: 161-7.
9. Nahata M, Muto S, Oridate N, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Hattori T et al. Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease. Am J Physiol Gastrointest Liver Physiol 2012; 303: G42-53.
10. Takeda H, Sadakane C, Hattori T, Katsurada T, Ohkawara T, Nagai K, Asaka M. Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology 2008; 134: 2004-13.
11. Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A. Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin. Biol Psychiatry 2009; 65: 748-59.
12. Knowles CH, Aziz Q. Visceral hypersensitivity in non-erosive reflux disease. Gut 2008; 57: 674-83.
13. Knowles CH, Aziz Q. Basic and clinical aspects of gastrointestinal pain. Pain 2009; 141: 191-209.
14. Xu X, Li Z, Zou D, Yang M, Liu Z, Wang X. High expression of calcitonin gene-related peptide and substance P in esophageal mucosa of patients with non-erosive reflux disease. Dig Dis Sci 2013; 58: 53-60.
15. Ma J, Altomare A, Rieder F, Behar J, Biancani P, Harnett KM. ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. Am J Physiol Gastrointest Liver Physiol 2011; 301: G1075-82.
16. Yoshida N, Kuroda M, Suzuki T, Kamada K, Uchiyama K, Handa O, Takagi T, Yoshikawa T et al. Role of Nociceptors/Neuropeptides in the Pathogenesis of Visceral Hypersensitivity of Nonerosive Reflux Disease. Dig Dis Sci 2013; 58: 2237-43.
17. Harnett KM, Rieder F, Behar J, Biancani P. Viewpoints on Acid-induced inflammatory mediators in esophageal mucosa. J Neurogastroenterol Motil 2010; 16: 374-88.
18. Banerjee B, Medda BK, Lazarova Z, Bansal N, Shaker R, Sengupta JN. Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats. Neurogastroenterol Motil 2007; 19: 681-91.
19. Dai Y, Iwata K, Fukuoka T, Kondo E, Tokunaga A, Yamanaka H, Tachibana T, Liu Y et al. Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci 2002; 22: 7737-45.
20. Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, Fukuoka T, Tokunaga A et al. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci 2004; 24: 10211-22.
21. Sakurai J, Obata K, Ozaki N, Tokunaga A, Kobayashi K, Yamanaka H, Dai Y, Kondo T et al. Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats. Gastroenterology 2008; 134: 1094-103.
22. Harrington AM, Brierley SM, Isaacs NJ, Young RL, Ashley Blackshaw L. Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterol Motil 2013; 25: e660-8.
23. Gao YJ, Ji RR. c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? Open Pain J 2009; 2: 11-7.
24. Qiao LY, Gulick MA, Bowers J, Kuemmerle JF, Grider JR. Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis. Neurogastroenterol Motil 2008; 20: 928-38.
25. Miwa H, Oshima T, Sakurai J, Tomita T, Matsumoto T, Iizuka S, Koseki J. Experimental oesophagitis in the rat is associated with decreased voluntary movement. Neurogastroenterol Motil 2009; 21: 296-303.
26. Miwa H, Koseki J, Oshima T, Kondo T, Tomita T, Watari J, Matsumoto T, Hattori T et al. Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa. J Gastroenterol 2010; 45: 478-87.
27. Omura N, Kashiwagi H, Chen G, Suzuki Y, Yano F, Aoki T. Establishment of surgically induced chronic acid reflux esophagitis in rats. Scand J Gastroenterol 1999; 34: 948-53.
28. Oshima T, Koseki J, Sakurai J, Watari J, Matsumoto T, Miwa H. NK-1 receptor is involved in the decreased movement in a rat chronic acid reflux oesophagitis model. Neurogastroenterol Motil 2010; 22: 579-84, e125.
29. Kondo T, Obata K, Miyoshi K, Sakurai J, Tanaka J, Miwa H, Noguchi K. Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats. Gut 2009; 58: 1342-52.
30. Michael GJ, Averill S, Nitkunan A, Rattray M, Bennett DL, Yan Q, Priestley JV. Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. J Neurosci 1997; 17: 8476-90.
31. Pandolfino JE, Kwiatek MA, Kahrilas PJ. The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease. Gastroenterol Clin North Am 2008; 37: 827-43, viii.
32. El-Serag HB. Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol 2007; 5: 17-26.
33. Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol 2009; 44: 518-34.
34. Miwa H, Sasaki M, Furuta T, Koike T, Habu Y, Ito M, Fujiwara Y, Wada T et al. Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease: a multicenter study from Japan. Aliment Pharmacol Ther 2007; 26: 69-77.
35. Bytzer P. What makes individuals with gastroesophageal reflux disease dissatisfied with their treatment? Clin Gastroenterol Hepatol 2009; 7: 816-22.
36. Dean BB, Gano AD Jr, Knight K, Ofman JJ, Fass R. Effectiveness of proton pump inhibitors in nonerosive reflux disease. Clin Gastroenterol Hepatol 2004; 2: 656-64.
37. Dellon ES, Shaheen NJ. Persistent reflux symptoms in the proton pump inhibitor era: the changing face of gastroesophageal reflux disease. Gastroenterology 2010; 139: 7-13 e13.
38. Aley KO, Martin A, McMahon T, Mok J, Levine JD, Messing RO. Nociceptor sensitization by extracellular signal-regulated kinases. J Neurosci 2001; 21: 6933-9.
39. Ma W, Zheng WH, Powell K, Jhamandas K, Quirion R. Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study. Eur J Neurosci 2001; 14: 1091-104.
40. Tang HB, Inoue A, Iwasa M, Hide I, Nakata Y. Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. J Neurochem 2006; 97: 1412-8.
41. Ang SF, Moochhala SM, MacAry PA, Bhatia M. Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-kappaB signaling. PLoS ONE 2011; 6: e24535.
42. Seino D, Tokunaga A, Tachibana T, Yoshiya S, Dai Y, Obata K, Yamanaka H, Kobayashi K et al. The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint. Pain 2006; 123: 193-203.
43. Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV. Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Mol Cell Neurosci 2001; 18: 183-96.
44. Rashid MH, Inoue M, Matsumoto M, Ueda H. Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice. J Pharmacol Exp Ther 2004; 308: 1158-64.
45. Chen X, Oshima T, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H. Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins. Am J Physiol Gastrointest Liver Physiol 2011; 301: G203-9.
46. Chen X, Oshima T, Shan J, Fukui H, Watari J, Miwa H. Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins. Am J Physiol Gastrointest Liver Physiol 2012; 303: G199-208.
47. Oshima T, Koseki J, Chen X, Matsumoto T, Miwa H. Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers. Lab Invest 2012; 92: 22-31.
48. Oguro M, Koike M, Ueno T, Asaoka D, Mori H, Nagahara A, Uchiyama Y, Watanabe S. Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease. J Gastroenterol 2011; 46: 629-38.
49. Kondo T, Oshima T, Obata K, Sakurai J, Knowles CH, Matsumoto T, Noguchi K, Miwa H. Role of transient receptor potential A1 in gastric nociception. Digestion 2010; 82: 150-5.