A Phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 89, Issue 4, 2014, Pages 830-838

  Hong, Theodore S ^a   Ryan, David P ^a   Borger, Darrell R ^a   Blaszkowsky, Lawrence S ^a   Yeap, Beow Y ^a   Ancukiewicz, Marek ^a   Deshpande, Vikram ^a   Shinagare, Shweta ^a   Wo, Jennifer Y ^a   Boucher, Yves ^a   Wadlow, Raymond C ^a   Kwak, Eunice L ^a   Allen, Jill N ^a   Clark, Jeffrey W ^a   Zhu, Andrew X ^a   Ferrone, Cristina R ^a   Mamon, Harvey J ^b   Adams, Judith ^a   Winrich, Barbara ^a   Grillo, Tarin ^a   Jain, Rakesh K ^a   Delaney, Thomas F ^a   Fernandez Del Castillo, Carlos ^a   Duda, Dan G ^a   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOMARKERS; CHEMORADIOTHERAPY; PROTON BEAMS; SURGERY; TOXICITY;

CHEST WALL PAINS; DUCTAL ADENOCARCINOMAS; EXPLORATORY ANALYSIS; METHODS AND MATERIALS; PERIPHERAL BLOOD; PRIMARY OBJECTIVE; PROGRESSION FREE SURVIVAL; SURGICAL SPECIMENS;

PROTON BEAM THERAPY;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ASPARTIC ACID; BILIRUBIN; BIOLOGICAL MARKER; CA 19-9 ANTIGEN; CAPECITABINE; CARCINOEMBRYONIC ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; GLYCINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; K RAS PROTEIN; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ABDOMINAL PAIN; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; COLITIS; CONSTIPATION; DEHYDRATION; DIARRHEA; FEMALE; FLATULENCE; FOLLOW UP; GENOTYPE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NAUSEA; NAUSEA AND VOMITING; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREATICODUODENECTOMY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; POINT MUTATION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTON THERAPY; RADIATION DOSE; REVIEW; THORAX PAIN; WEIGHT REDUCTION;

AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; CA-19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CARCINOMA, PANCREATIC DUCTAL; CHEMORADIOTHERAPY, ADJUVANT; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; GENES, RAS; HEPATOCYTE GROWTH FACTOR; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PANCREATICODUODENECTOMY; PROGNOSIS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS; PROTON THERAPY; RAS PROTEINS; RECEPTORS, CXCR; TUMOR MARKERS, BIOLOGICAL;

EID: 84903268334     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2014.03.034     Document Type: Article

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