The effect of intrathecal administration trpa1 antagonists in a rat model of neuropathic pain

Anesthesia and Analgesia

Volumn 119, Issue 1, 2014, Pages 179-185

  Zhang, Wei ^a   Liu, Yue ^a   Zhao, Xin ^a   Gu, Xiaoping ^a   Ma, Zhengliang ^a  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1 ANTAGONIST; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DORSAL ROOT; HYPERALGESIA; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPINAL CORD; UPREGULATION; WESTERN BLOTTING;

ACETANILIDES; ANIMALS; DISEASE MODELS, ANIMAL; HYPERALGESIA; INJECTIONS, SPINAL; MALE; NEURALGIA; PURINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TRPC CATION CHANNELS;

EID: 84903268005     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000000179     Document Type: Article

References (36)

1. Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov 2009;8:55-68
2. Moran MM, McAlexander MA, Bíró T, Szallasi A. Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov 2011;10:601-20
3. Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxi-dative stress. J Neurosci 2008;28:2485-94 (Pubitemid 351348185)
4. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 2004;41:849-57 (Pubitemid 38429729)
5. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and can-nabinoids excite sensory nerve fbres through the TRP channel ANKTM1. Nature 2004;427:260-5 (Pubitemid 38112043)
6. Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A. An ion channel essential for sensing chemical damage. J Neurosci 2007;27:11412-5 (Pubitemid 47621302)
7. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci USA 2007;104:13525-30 (Pubitemid 47293978)
8. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic infammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 2007;104:13519-24 (Pubitemid 47293977)
9. da Costa DS, Meotti FC, Andrade EL, Leal PC, Motta EM, Calixto JB. The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyper-algesia in persistent infammation. Pain 2010;148:431-7
10. Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, Henze DA, Kane SA, Urban MO. HC-030031, a TRPA1 selective antagonist, attenuates infammatory-and neuropathy-induced mechanical hypersensitivity. Mol Pain 2008;4:48
11. Kerstein PC, del Camino D, Moran MM, Stucky CL. Pharmacological blockade of TRPA1 inhibits mechanical fring in nociceptors. Mol Pain 2009;5:19
12. Kwan KY, Glazer JM, Corey DP, Rice FL, Stucky CL. TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci 2009;29:4808-19
13. Petrus M, Peier AM, Bandell M, Hwang SW, Huynh T, Olney N, Jegla T, Patapoutian A. A role of TRPA1 in mechanical hyperalge-sia is revealed by pharmacological inhibition. Mol Pain 2007;3:40
14. Wei H, Hämäläinen MM, Saarnilehto M, Koivisto A, Pertovaara A. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 2009;111:147-54
15. Wei H, Koivisto A, Saarnilehto M, Chapman H, Kuokkanen K, Hao B, Huang JL, Wang YX, Pertovaara A. Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain 2011;152:582-91
16. Wei H, Karimaa M, Korjamo T, Koivisto A, Pertovaara A. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology 2012;117:137-48
17. Uta D, Furue H, Pickering AE, Rashid MH, Mizuguchi-Takase H, Katafuchi T, Imoto K, Yoshimura M. TRPA1-expressing primary afferents synapse with a morphologically identifed subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur J Neurosci 2010;31:1960-73
18. Wrigley PJ, Jeong HJ, Vaughan CW. Primary afferents with TRPM8 and TRPA1 profles target distinct subpopulations of rat superfcial dorsal horn neurones. Br J Pharmacol 2009;157:371-80
19. Wei H, Chapman H, Saarnilehto M, Kuokkanen K, Koivisto A, Pertovaara A. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology 2010;58:578-84
20. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10 (Pubitemid 13058546)
21. Yaksh TL, Rudy TA. Chronic catheterization of the spinal sub-arachnoid space. Physiol Behav 1976;17:1031-6 (Pubitemid 8063691)
22. Gu X, Yang L, Wang S, Sung B, Lim G, Mao J, Zeng Q, Yang C, Mao J. A rat model of radicular pain induced by chronic compression of lumbar dorsal root ganglion with SURGIFLO. Anesthesiology 2008;108:113-21
23. Hu SJ, Xing JL. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain 1998;77:15-23
24. Song XJ, Hu SJ, Greenquist KW, Zhang JM, LaMotte RH. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol 1999;82:3347-58 (Pubitemid 30017459)
25. Bandell M, Macpherson LJ, Patapoutian A. From chills to chilis: mechanisms for thermosensation and chemesthesis via ther-moTRPs. Curr Opin Neurobiol 2007;17:490-7 (Pubitemid 47531955)
26. Andrade EL, Luiz AP, Ferreira J, Calixto JB. Pronociceptive response elicited by TRPA1 receptor activation in mice. Neuroscience 2008;152:511-20
27. Roberts K, Shenoy R, Anand P. A novel human volunteer pain model using contact heat evoked potentials (CHEP) following topical skin application of transient receptor potential agonists capsa-icin, menthol and cinnamaldehyde. J Clin Neurosci 2011;18:926-32
28. Pertovaara A, Koivisto A. TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic infammation. Eur J Pharmacol 2011;666:1-4
29. Kosugi M, Nakatsuka T, Fujita T, Kuroda Y, Kumamoto E. Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. J Neurosci 2007;27:4443-51 (Pubitemid 46640705)
30. Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, Ahn DK, Bae YC. Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn. J Comp Neurol 2010;518:687-98
31. Zhang W, Shi CX, Gu XP, Ma ZL, Zhu W. Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats. Anesth Analg 2009;108:1015-20
32. Guo W, Zou S, Guan Y, Ikeda T, Tal M, Dubner R, Ren K. Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of infammatory hyperalgesia. J Neurosci 2002;22:6208-17 (Pubitemid 35387661)
33. Yang Q, Liao ZH, Xiao YX, Lin QS, Zhu YS, Li ST. Hippocampal synaptic metaplasticity requires the activation of NR2B-containing NMDA receptors. Brain Res Bull 2011;84:137-43
34. Jung SC, Eun SY, Kim J, Hoffman DA. Kv4.2 block of long-term potentiation is partially dependent on synaptic NMDA receptor remodeling. Brain Res Bull 2011;84:17-21
35. Guo W, Wei F, Zou S, Robbins MT, Sugiyo S, Ikeda T, Tu JC, Worley PF, Dubner R, Ren K. Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with infammatory hyperalgesia. J Neurosci 2004;24:9161-73 (Pubitemid 39372260)
36. Klafke JZ, da Silva MA, Trevisan G, Rossato MF, da Silva CR, Guerra GP, Villarinho JG, Rigo FK, Dalmolin GD, Gomez MV, Rubin MA, Ferreira J. Involvement of the glutamatergic system in the nociception induced intrathecally for a TRPA1 agonist in rats. Neuroscience 2012;222:136-46