메뉴 건너뛰기




Volumn 27, Issue 3, 2014, Pages 166-172

The combination of neoadjuvant chemoradiotherapy and epidermal growth factor receptor inhibitors in the treatment of rectal adenocarcinoma;Neoadjuvantní chemoradioterapie karcinomu rekta v kombinaci s inhibitory receptoru pro ru°stový epidermální faktor

Author keywords

Chemoradiotherapy; Epidermal growth factor receptor; Monoclonal antibodies; Rectal cancer

Indexed keywords

CAPECITABINE; FLUOROURACIL; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 84903201270     PISSN: 0862495X     EISSN: 18025307     Source Type: Journal    
DOI: 10.14735/amko2014166     Document Type: Review
Times cited : (3)

References (81)
  • 2
    • 33750965568 scopus 로고    scopus 로고
    • Chemoradioterapie karcinomu konečníku
    • Šlampa P, Soumarov̌ R, Kocáková I et al. Praha: Galén
    • Kocáková I, Soumarová R. Chemoradioterapie karcinomu konečníku. In: Šlampa P, Soumarov̌ R, Kocáková I et al. Konkomitantní chemoradioterapie solidních nádoru̇. Praha: Galén 2005:62-72.
    • (2005) Konkomitantní Chemoradioterapie Solidních Nádoru̇ , pp. 62-72
    • Kocáková, I.1    Soumarová, R.2
  • 3
    • 0035922657 scopus 로고    scopus 로고
    • Adjuvant radiotherapy for rectal cancer: A systematic overview of 8507 patients from 22 randomised trials
    • DOI 10.1016/S0140-6736(01)06409-1
    • Gray R, Hills R, Stowe R et al. Adjuvant radiotherapy for rectal cancer, a systemic overview of 8507 patients from 22 randomised trials. Lancet 2001; 358(9290): 1291-1304. (Pubitemid 33016492)
    • (2001) Lancet , vol.358 , Issue.9290 , pp. 1291-1304
    • Gray, R.1    Hills, R.2    Stowe, R.3    Clarke, M.4    Peto, R.5    Buyse, M.6    Piedbois, P.7
  • 4
    • 84903210261 scopus 로고    scopus 로고
    • Karcinomy konečniku
    • Šlampa P et al (eds). Brno: Masaryku̇v onkologický ústav
    • Šlampa P, Lovas P, Lovasová Z et al. Karcinomy konečniku. In: Šlampa P et al (eds). Radiační onkologie v praxi. 3. vyd. Brno: Masaryku̇v onkologický ústav 2011: 70-78.
    • (2011) Radiační Onkologie V Praxi. 3. Vyd. , pp. 70-78
    • Šlampa, P.1    Lovas, P.2    Lovasová, Z.3
  • 5
    • 33747270013 scopus 로고    scopus 로고
    • Does rectal cancer shrinkage by preoperative radiochemotherapy increase the likelihood of anterior resection? A systemic review of randomised trilas
    • Bujko K, Kepka L, Michalski W et al. Does rectal cancer shrinkage by preoperative radiochemotherapy increase the likelihood of anterior resection? A systemic review of randomised trilas. Radiother Oncol 2006; 80(1): 4-12.
    • (2006) Radiother Oncol , vol.80 , Issue.1 , pp. 4-12
    • Bujko, K.1    Kepka, L.2    Michalski, W.3
  • 6
    • 35948978607 scopus 로고    scopus 로고
    • Pre-operative radiotherapy and curative surgery for the management of lacalized rectal carcinoma
    • Wong RK, Tandan V, De Silva S et al. Pre-operative radiotherapy and curative surgery for the management of lacalized rectal carcinoma. Cochrane Database Syst Rev 2007; CD002102.
    • (2007) Cochrane Database Syst Rev
    • Wong, R.K.1    Tandan, V.2    De Silva, S.3
  • 7
    • 85136397322 scopus 로고    scopus 로고
    • The oxygen effect and fractionated radiotherapy
    • Joiner M, van der Kogel London: Edward Arnold
    • Horsman MR, Wouters BG, Joiner MC et al (eds). The oxygen effect and fractionated radiotherapy. In: Joiner M, van der Kogel A Basic clinical radiobiology. 4th ed. London: Edward Arnold 2009: 207-216.
    • (2009) A Basic Clinical Radiobiology. 4th Ed. , pp. 207-216
    • Horsman, M.R.1    Wouters, B.G.2    Joiner, M.C.3
  • 8
    • 6044226542 scopus 로고    scopus 로고
    • Preoperative versus postoperative chemoradiotherapy for rectal cancer
    • Sauer R, Becker H, Hohenberger W et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351 (17): 1731-1740.
    • (2004) N Engl J Med , vol.351 , Issue.17 , pp. 1731-1740
    • Sauer, R.1    Becker, H.2    Hohenberger, W.3
  • 9
    • 84860918386 scopus 로고    scopus 로고
    • Preoperative versus postoperative chemoradiotherapy for rectal cancer: Results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years
    • doi: 10.1200/JCO.2011.40.1836.
    • Sauer R, LierschT, Merkel S et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol 2012; 30(16): 1926-1933. doi: 10.1200/JCO.2011.40.1836.
    • (2012) J Clin Oncol , vol.30 , Issue.16 , pp. 1926-1933
    • Sauer, R.1    Liersch, T.2    Merkel, S.3
  • 10
    • 24944499364 scopus 로고    scopus 로고
    • Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: Preliminary results EORTC 22921
    • Bosset JF, Calais G, Mineur L et al. Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results EORTC 22921. J Clin Oncol 2005; 23(24): 5620-5627.
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5620-5627
    • Bosset, J.F.1    Calais, G.2    Mineur, L.3
  • 11
    • 35348817933 scopus 로고    scopus 로고
    • Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: Does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group
    • DOI 10.1200/JCO.2007.11.9685
    • Collette L, Bosset JF, den Dulk M et al. Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or chemoradiotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the EORTC. J Clin Oncol 2007; 25(28): 4379-4386. (Pubitemid 350013843)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.28 , pp. 4379-4386
    • Collette, L.1    Bosset, J.-F.2    Den, D.M.3    Nguyen, F.4    Mineur, L.5    Maingon, P.6    Radosevic-Jelic, L.7    Pierart, M.8    Calais, G.9
  • 13
    • 68549125707 scopus 로고    scopus 로고
    • Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer
    • doi: 10.1002/14651858.CD006041.pub2
    • Ceelen WP, Van Nieuwenhove Y, Fierens K. Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer. Cochrane Database Syst Rev 2009: CD006041. doi: 10.1002/14651858.CD006041.pub2.
    • (2009) Cochrane Database Syst Rev
    • Ceelen, W.P.1    Van Nieuwenhove, Y.2    Fierens, K.3
  • 14
    • 84861547511 scopus 로고    scopus 로고
    • Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer a randomised, multicentre, non-inferiority, phase 3 trial
    • doi: 10.1016/S1470-20450270116-X
    • Hofheinz RD, Wenz F, Post S et al. Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer a randomised, multicentre, non-inferiority, phase 3 trial. Lancet Oncol 2012; 13(6): 579-588. doi: 10.1016/S1470-204502)70116-X.
    • (2012) Lancet Oncol , vol.13 , Issue.6 , pp. 579-588
    • Hofheinz, R.D.1    Wenz, F.2    Post, S.3
  • 15
    • 80053103472 scopus 로고    scopus 로고
    • The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rektum: NSABP R-04 (abstrakt)
    • Roh MS, Yothers GA, O'Connell MJ et al. The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rektum: NSABP R-04 (abstrakt). J Clin Oncol 2011; 29 (Suppl 15): 3503.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 15 , pp. 3503
    • Roh, M.S.1    Yothers, G.A.2    O'Connell, M.J.3
  • 16
    • 79960242791 scopus 로고    scopus 로고
    • Primary tumor response to preoperative chemoradiotion with or without oxaliplatin in locally advanced rectal cancer: Pathologic resuits of the STAR-01 randomized phase III trial
    • doi: 10.1200/JCO.2010.34.4911
    • Aschele C, Cionini L, Lonardi S et al. Primary tumor response to preoperative chemoradiotion with or without oxaliplatin in locally advanced rectal cancer: pathologic resuits of the STAR-01 randomized phase III trial. J Clin Oncol 2011; 29(20): 2773-2780. doi: 10.1200/JCO.2010.34.4911.
    • (2011) J Clin Oncol , vol.29 , Issue.20 , pp. 2773-2780
    • Aschele, C.1    Cionini, L.2    Lonardi, S.3
  • 17
    • 77950495945 scopus 로고    scopus 로고
    • Comparison of two neoadjuvant chemoradiotherapy regiment for locally advanced rectal cancer: Results of the phase III trial ACCORD 12/0405 - Prodige 2
    • doi: 10.1200/JCO.2009.25.8376
    • Gérard JR Azria D, Gourgou-Bourgade S et al. Comparison of two neoadjuvant chemoradiotherapy regiment for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405 - prodige 2. J Clin Oncol 2010; 28(10): 1638-1644. doi: 10.1200/JCO.2009.25.8376.
    • (2010) J Clin Oncol , vol.28 , Issue.10 , pp. 1638-1644
    • Gérard, J.R.1    Azria, D.2    Gourgou-Bourgade, S.3
  • 18
    • 84863106037 scopus 로고    scopus 로고
    • Preoperative chemoradiotherapy and post postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: Initial results of German CAO/ARO/AIO-04 randomised phase 3 trial
    • Rodel C, Liersch T, Becker H et al. Preoperative chemoradiotherapy and post postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol 2012.
    • (2012) Lancet Oncol
    • Rodel, C.1    Liersch, T.2    Becker, H.3
  • 20
    • 58149174388 scopus 로고    scopus 로고
    • Receptor pro epidermální ru̇stový faktor a jeho úloha v radioterapii
    • Sirák I, Hartlová J, Petera J et al. Receptor pro epidermální ru̇stový faktor a jeho úloha v radioterapii. Klin Okol 2008; 21 (6): 338-347.
    • (2008) Klin Okol , vol.21 , Issue.6 , pp. 338-347
    • Sirák, I.1    Hartlová, J.2    Petera, J.3
  • 22
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • PII S0959804901002301
    • Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanism and therapeutic opportunities. Eur J Cancer 2001; 37 (Suppl 4): S3-S8. (Pubitemid 32938123)
    • (2001) European Journal of Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 23
    • 41049084427 scopus 로고    scopus 로고
    • The status and role of ErbB receptors in human cancer
    • doi: 10.1016/j.yexmp.2007.12.002
    • Uberall I, Kolár Z, Trojanec R et al. The status and role of ErbB receptors in human cancer. Exp Mol Pathol 2008; 84(2): 79-89. doi: 10.1016/j.yexmp.2007.12.002.
    • (2008) Exp Mol Pathol , vol.84 , Issue.2 , pp. 79-89
    • Uberall, I.1    Kolár, Z.2    Trojanec, R.3
  • 24
    • 0032719534 scopus 로고    scopus 로고
    • Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas
    • Akimoto T, Hunter NR, Buchmiller L et al. Inverse relationship between epidermal growth factor expression and radiocurability of murine carcinomas. Clin Cancer Res 1999; 5(10): 2884-2890. (Pubitemid 29493967)
    • (1999) Clinical Cancer Research , vol.5 , Issue.10 , pp. 2884-2890
    • Akimoto, T.1    Hunter, N.R.2    Buchmiller, L.3    Mason, K.4    Ang, K.K.5    Milas, L.6
  • 26
    • 0032549570 scopus 로고    scopus 로고
    • Overexpression of EGFR and c-erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts
    • DOI 10.1016/S0014-5793(98)00224-5, PII S0014579398002245
    • Verbeek BS, Andriaansen-Slot SS, Vroom TM et al. Overexpression of EGFR and c-erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts. FEBS Lett 1998; 425(1): 145-150. (Pubitemid 28149759)
    • (1998) FEBS Letters , vol.425 , Issue.1 , pp. 145-150
    • Verbeek, B.S.1    Adriaansen-Slot, S.S.2    Vroom, T.M.3    Beckers, T.4    Rijksen, G.5
  • 27
    • 0025606461 scopus 로고
    • Epidermal growth factor receptor expression in colorectal cancer
    • Steele RJ, Kelly P, Ellul B et al. Epidermal growth factor receptor expression in colorectal cancer. Br J Surg 1990; 77(12): 1352-1354.
    • (1990) Br J Surg , vol.77 , Issue.12 , pp. 1352-1354
    • Steele, R.J.1    Kelly, P.2    Ellul, B.3
  • 28
    • 0027415146 scopus 로고
    • The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
    • Mayer A, Takimoto M, Fritz E et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and MDR gene expression in colorectal cancer. Cancer 1993; 71 (8): 2454-2460. (Pubitemid 23100476)
    • (1993) Cancer , vol.71 , Issue.8 , pp. 2454-2460
    • Mayer, A.1    Takimoto, M.2    Fritz, E.3    Schellander, G.4    Kofler, K.5    Ludwig, H.6
  • 29
    • 0037441914 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with stage II and stage III colon carcinoma: A role for the host response in prognosis
    • DOI 10.1002/cncr.11152
    • Khorana AA, Ryan CK, Cox et al. Vascular enndothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with stage II and stage III colon carcinoma: a role for the host response in prognosis. Cancer 2003; 97(4): 960-968. (Pubitemid 36173146)
    • (2003) Cancer , vol.97 , Issue.4 , pp. 960-968
    • Khorana, A.A.1    Ryan, C.K.2    Cox, C.3    Eberly, S.4    Sahasrabudhe, D.M.5
  • 30
    • 0042783111 scopus 로고    scopus 로고
    • Clinical implications of the EGF receptor ligand system for tumour progression and survival in gastrointestinal carcinomas: Evidence for new therapeutic options
    • Kopp R, Rothbauer E, Ruge M et al. Clinical implications of the EGF receptor ligand system for tumour progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options. Recent Results Cancer Res 2003; 162: 115-132.
    • (2003) Recent Results Cancer Res , vol.162 , pp. 115-132
    • Kopp, R.1    Rothbauer, E.2    Ruge, M.3
  • 32
    • 0031891006 scopus 로고    scopus 로고
    • Physical interaction between epidermal growth factor receptor and DNA- dependent protein kinase in mammalian cells
    • DOI 10.1074/jbc.273.3.1568
    • Bandyopathy D, Mandal M, Adam L et al. Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J Biol Chem 1998; 273(3): 1568-1573. (Pubitemid 28133681)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.3 , pp. 1568-1573
    • Bandyopadhyay, D.1    Mandal, M.2    Adam, L.3    Mendelsohn, J.4    Kumar, R.5
  • 33
    • 69949134989 scopus 로고    scopus 로고
    • Receptor signailing as a regulatory mechanism of DNA repair
    • doi: 10.1016/j.ra-donc.2009.06.031
    • Meyn RE, Munshi A, Haymach JV et al. Receptor signailing as a regulatory mechanism of DNA repair. Radiother Oncol 2009; 92(3): 316-322. doi: 10.1016/j.ra-donc.2009.06.031.
    • (2009) Radiother Oncol , vol.92 , Issue.3 , pp. 316-322
    • Meyn, R.E.1    Munshi, A.2    Haymach, J.V.3
  • 35
    • 0023894783 scopus 로고
    • The hazard of accelerated tumor donogen repopulation during radiotherapy
    • Withers HR, Taylor JM, Maciejewski B. The hazard of accelerated tumor donogen repopulation during radiotherapy. Acta Oncol 1988; 27(2): 131-146.
    • (1988) Acta Oncol , vol.27 , Issue.2 , pp. 131-146
    • Withers, H.R.1    Taylor, J.M.2    Maciejewski, B.3
  • 36
    • 0142234861 scopus 로고    scopus 로고
    • Mechanism of repopulation in experimental squamos cell carcinoma
    • Kogelnik HD, Lukas P, Sedlmayer F (eds). Bologna: Monduzzi
    • Baumann M, Petersen C, Eichler W et al. Mechanism of repopulation in experimental squamos cell carcinoma. In: Kogelnik HD, Lukas P, Sedlmayer F (eds). Progress in radiation-oncology, vol. 7. Bologna: Monduzzi 2002:417-422.
    • (2002) Progress in Radiation-oncology , vol.7 , pp. 417-422
    • Baumann, M.1    Petersen, C.2    Eichler, W.3
  • 37
    • 0028084788 scopus 로고
    • Prediction of repopulation rates and radiosensitivity in human tumours
    • Begg AC. Prediction of repopulation rates and radiosensitivity in human tumours. Int J Radiat Biol 1994; 65(1): 103-108. (Pubitemid 24063536)
    • (1994) International Journal of Radiation Biology , vol.65 , Issue.1 , pp. 103-108
    • Begg, A.C.1
  • 38
    • 0025719447 scopus 로고
    • Rapid repopulation in radiotherapy: A debate on mechanism. The phantom of tumor treatment -continually rapid proliferation inmasked
    • Fowler JF. Rapid repopulation in radiotherapy: a debate on mechanism. The phantom of tumor treatment -continually rapid proliferation inmasked. Radiother Oncol 1991; 22(3): 156-158.
    • (1991) Radiother Oncol , vol.22 , Issue.3 , pp. 156-158
    • Fowler, J.F.1
  • 40
    • 33646941041 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as a prognostic factor in locally advanced rectal cancer patiens treated with preoperative chemoradiotion
    • Li S, Kim JS, Kim JM et al. Epidermal growth factor receptor as a prognostic factor in locally advanced rectal cancer patiens treated with preoperative chemoradiotion. Int J Radiat Oncol Biol Phys 2006; 65(3): 1019-1028.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , Issue.3 , pp. 1019-1028
    • Li, S.1    Kim, J.S.2    Kim, J.M.3
  • 42
    • 34547445551 scopus 로고    scopus 로고
    • Prognostic and predictive value of baseline and post-treatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
    • Bertolini F, Bengala C, Losi L et al. Prognostic and predictive value of baseline and post-treatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. Int J Radiat Oncol Biol Phys 2007; 68(5): 1455-1468.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , Issue.5 , pp. 1455-1468
    • Bertolini, F.1    Bengala, C.2    Losi, L.3
  • 43
    • 38549120954 scopus 로고    scopus 로고
    • Combined analysis of VEGF and EGFR predicts komplete tumour response in rectal cancer treated with preoperative radiotherapy
    • doi: 10.1038/sj. bjc.6604172
    • Zlobec I, Vuong T, Compton CC et al. Combined analysis of VEGF and EGFR predicts komplete tumour response in rectal cancer treated with preoperative radiotherapy. Br J Cancer 2008; 98(2): 450-456. doi: 10.1038/sj. bjc.6604172.
    • (2008) Br J Cancer , vol.98 , Issue.2 , pp. 450-456
    • Zlobec, I.1    Vuong, T.2    Compton, C.C.3
  • 44
    • 26844465462 scopus 로고    scopus 로고
    • Prognostic impact of epidermal growth factor receptor (EGFR) expression on loco-regional recurrence after preoperative radiotherapy in rectal cancer
    • Azria D, Bibeau F, Barbier N et al. Prognostic impact of epidermal growth factor receptor (EGFR) expression on loco-regional recurrence after preoperative radiotherapy in rectal cancer. BMC Cancer 2005; 5:62.
    • (2005) BMC Cancer , vol.5 , pp. 62
    • Azria, D.1    Bibeau, F.2    Barbier, N.3
  • 45
    • 84896709127 scopus 로고    scopus 로고
    • The prognostic significance of changes of tumor epidermal growth factor receptor expression after neoadjuvant chemoradiation in patients with rectal adenocarcinoma
    • Dvořak J, Sitorová V, Ryška A et al. The prognostic significance of changes of tumor epidermal growth factor receptor expression after neoadjuvant chemoradiation in patients with rectal adenocarcinoma. Strahlenter Onkol 2012; 10: 145-147.
    • (2012) Strahlenter Onkol , vol.10 , pp. 145-147
    • Dvořak, J.1    Sitorová, V.2    Ryška, A.3
  • 47
    • 85047696958 scopus 로고    scopus 로고
    • ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model
    • Williams KJ, Telfer BA, Stratford U et al. ZD1839 (Iressa), a specific oral epidermal growth factor receptor tyrosine kinase inhibitor potentiates radiohterapy in a human colorectal cancer xenograft model. Br J Cancer 2002; 86(7): 1157-1161. (Pubitemid 34438090)
    • (2002) British Journal of Cancer , vol.86 , Issue.7 , pp. 1157-1161
    • Williams, K.J.1    Telfer, B.A.2    Stratford, I.J.3    Wedge, S.R.4
  • 48
    • 52949123178 scopus 로고    scopus 로고
    • Infusional 5-fluorouracil and ZD 1839 (gefitinib-lressa) in combination with preoperative radiotherapy in patiens with locally advanced rectal cancer: A phase I and II trial (18391L/0092)
    • doi: 10.1016/j-ijrobp.2008.01.046
    • Valentini V, De Paoli A, Gambacorta MA et al. Infusional 5-fluorouracil and ZD 1839 (gefitinib-lressa) in combination with preoperative radiotherapy in patiens with locally advanced rectal cancer: a phase I and II trial (18391L/0092). Int J Radiat Oncol Biol Phys 2008; 72(3): 644-649. doi: 10.1016/j-ijrobp.2008.01.046.
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , Issue.3 , pp. 644-649
    • Valentini, V.1    De Paoli, A.2    Gambacorta, M.A.3
  • 50
    • 39349083477 scopus 로고    scopus 로고
    • EGFR HER2, and K-ras as predictive factors for cetuximab sensitivity in colorectal cancer
    • Finocchiaro G, Capuzzo F, Janne PA et al. EGFR HER2, and K-ras as predictive factors for cetuximab sensitivity in colorectal cancer. J Clin Oncol 2007; 25: 168.
    • (2007) J Clin Oncol , vol.25 , pp. 168
    • Finocchiaro, G.1    Capuzzo, F.2    Janne, P.A.3
  • 51
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorine as fist-line treatment for metastatic colorectal cancer: Update analysis of overall survival according to tumor KRAS and BRAF station status
    • doi: 10.1200/JCO.2010.33.5091
    • Van Cutsem E, Köhne CH, Láng I et al. Cetuximab plus irinotecan, fluorouracil, and leucovorine as fist-line treatment for metastatic colorectal cancer: update analysis of overall survival according to tumor KRAS and BRAF station status. J Clin Oncol 2011; 29(15): 2011-2019. doi: 10.1200/JCO.2010.33.5091.
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 2011-2019
    • Van Cutsem, E.1    Köhne, C.H.2    Láng, I.3
  • 52
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • doi: 10.1200/JCO.2008.20.8397
    • Bokemeyer C, Bondarenko I, Makhson A et al. Fluorouracil, leucovorin and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009; 27(5): 663-671. doi: 10.1200/JCO.2008.20. 8397.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 53
    • 85100453011 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatine-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Maugham TS, Adams RA, Smith CG et al. Addition of cetuximab to oxaliplatine-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011; 377: 2013-2114.
    • (2011) Lancet , vol.377 , pp. 2013-2114
    • Maugham, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 54
    • 84861432557 scopus 로고    scopus 로고
    • Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorine and oxaliplatine (Nordic FLOX) versus FLOX alone in first-line treatment of metstatic colorectal cancer: The NORDIC-VII study
    • doi: 10.1200/JCO.2011.38.0915
    • Tveit KM, Guren T, Glimelius B et al. Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorine and oxaliplatine (Nordic FLOX) versus FLOX alone in first-line treatment of metstatic colorectal cancer: the NORDIC-VII study. J Clin Oncol 2012; 30(15): 1755-1762. doi: 10.1200/JCO.2011.38.0915.
    • (2012) J Clin Oncol , vol.30 , Issue.15 , pp. 1755-1762
    • Tveit, K.M.1    Guren, T.2    Glimelius, B.3
  • 56
    • 84883480854 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS and BRAF station in the phase III PRIME study of panitumumab (pmab) plus FOLFOX versus FOLFOX as first-line treatment (tx) for metastatic colorectal cancer (mCRC)
    • abstr. 3511
    • Oliner KS, Douillard JY, Siena S et al. Analysis of KRAS/NRAS and BRAF station in the phase III PRIME study of panitumumab (pmab) plus FOLFOX versus FOLFOX as first-line treatment (tx) for metastatic colorectal cancer (mCRC). J Clin Oncol 2013; 31 (Suppl): abstr. 3511.
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Oliner, K.S.1    Douillard, J.Y.2    Siena, S.3
  • 58
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
    • doi: 10.1200/JCO.2009.22.4295
    • Richman SD, Seymour MT, Cahmbers P et al. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 2009; 27(35): 5931-5937. doi: 10.1200/JCO.2009.22.4295.
    • (2009) J Clin Oncol , vol.27 , Issue.35 , pp. 5931-5937
    • Richman, S.D.1    Seymour, M.T.2    Cahmbers, P.3
  • 59
    • 33644842988 scopus 로고    scopus 로고
    • Prosnostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer
    • Rödel C Martus P, Papadoupolos T et al. Prosnostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 2005; 23(24): 8688-8696.
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 8688-8696
    • Rödel, C.1    Martus, P.2    Papadoupolos, T.3
  • 62
    • 77956185901 scopus 로고    scopus 로고
    • Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: A pooled analysis of indivudual patient data
    • doi: 10.1016/S1470-2045U(10)70172-8
    • Maas M, Nelemans PJ, Valentini V et al. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of indivudual patient data. Lancet Oncol 2010; 11(9): 835-844. doi: 10.1016/S1470-2045U(10)70172-8.
    • (2010) Lancet Oncol , vol.11 , Issue.9 , pp. 835-844
    • Maas, M.1    Nelemans, P.J.2    Valentini, V.3
  • 63
    • 27744566164 scopus 로고    scopus 로고
    • Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: Analysis of phase II/III trials
    • DOI 10.1259/bjr/86650067
    • Hartley A, Ho KF, McConkey C et al. Pathological complete response following preoperative chemoradiotheracy in rectal cancer: analysis of phase II/III trials. Br J Radiol 2005; 78(934): 934-938. (Pubitemid 41582245)
    • (2005) British Journal of Radiology , vol.78 , Issue.934 , pp. 934-938
    • Hartley, A.1    Ho, K.F.2    McConkey, C.3    Geh, J.I.4
  • 64
    • 33750904963 scopus 로고    scopus 로고
    • Phase I trial of preoperative cetuximab with concurrent continuous In-fusion 5-fluorouracil and pelvic radiation in patients with local-regionally advanced rectal cancer
    • Chung KY, Minsky B, Schrag D et al. Phase I trial of preoperative cetuximab with concurrent continuous In-fusion 5-fluorouracil and pelvic radiation in patients with local-regionally advanced rectal cancer. J Clin Oncol 2006; 24 (Suppl 18): 161.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18 , pp. 161
    • Chung, K.Y.1    Minsky, B.2    Schrag, D.3
  • 67
    • 33751169352 scopus 로고    scopus 로고
    • Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan and radiotherapy as neoadjuvant therapy for rectal cancer
    • Hofheinz RD, Horisberger K, Woernle C et al. Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan and radiotherapy as neoadjuvant therapy for rectal cancer. Int J Radiat Oncol Biol Phys 2006; 66(5): 1384-1390.
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , Issue.5 , pp. 1384-1390
    • Hofheinz, R.D.1    Horisberger, K.2    Woernle, C.3
  • 68
    • 67749097665 scopus 로고    scopus 로고
    • Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: Resuits of a Phase II MARGIT trial
    • doi: 10.1016/j.ijrobp.2008.10.014
    • Horisberger K, Treschl A, Mai S et al. Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: resuits of a Phase II MARGIT trial. Int J Radiat Oncol Biol Phys 2009; 74(5): 1487-1493. doi: 10.1016/j.ijrobp.2008.10.014.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , Issue.5 , pp. 1487-1493
    • Horisberger, K.1    Treschl, A.2    Mai, S.3
  • 69
    • 58149345226 scopus 로고    scopus 로고
    • Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab and pelvic radiotherapy: A phase II study in locally advanced rectal cancer
    • doi: 10.1016/j.ijrobp2008.04.065
    • Bertolini F, Chiara S, Bengala C et al. Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab and pelvic radiotherapy: a phase II study in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2009; 73(2): 466-472. doi: 10.1016/j.ijrobp2008.04.065.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , Issue.2 , pp. 466-472
    • Bertolini, F.1    Chiara, S.2    Bengala, C.3
  • 70
    • 38849166120 scopus 로고    scopus 로고
    • Phase II study of preoperative chemoradiation (CRT) with cetuximab, irinotecan and capecitabine in patients with locally advanced resectable rectal cancer
    • abstr.4045
    • Hong YS, Kim DY, Lee KS et al. Phase II study of preoperative chemoradiation (CRT) with cetuximab, irinotecan and capecitabine in patients with locally advanced resectable rectal cancer. J Clin Oncol 2007; 25 (Suppl 18):abstr.4045.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18
    • Hong, Y.S.1    Kim, D.Y.2    Lee, K.S.3
  • 71
    • 57849155450 scopus 로고    scopus 로고
    • Phase I trial of preoperative cetuximab in combination with oxaliplatine, capecitabine, and radiation therapy for locally advanced rectal cancer
    • Cabebe EC, Kuo T, Koong M et al. Phase I trial of preoperative cetuximab in combination with oxaliplatine, capecitabine, and radiation therapy for locally advanced rectal cancer. J Clin Oncol 2008; 26 (Suppl): 15019.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. , pp. 15019
    • Cabebe, E.C.1    Kuo, T.2    Koong, M.3
  • 72
    • 77951261079 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiation therapy with capecitabine plus cetuximab and external beam radiotherapy in locally advanced rectal cancer (LARC) ABCSG trial R03
    • Eisterer WM, De Vries A, Oefner D et al. Neoadjuvant chemoradiation therapy with capecitabine plus cetuximab and external beam radiotherapy in locally advanced rectal cancer (LARC) ABCSG trial R03. J Clin Oncol 2009; 27 (Suppl): 4109.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 4109
    • Eisterer, W.M.1    De Vries, A.2    Oefner, D.3
  • 73
    • 84866160689 scopus 로고    scopus 로고
    • Neoadjuvant cetuximab, capecitabine, and radiotherapy (RT) in locally advanced resectable rectal cancer: Results of a phase II trial
    • Velenik V, Ocvirk J, Oblak I et al. Neoadjuvant cetuximab, capecitabine, and radiotherapy (RT) in locally advanced resectable rectal cancer: results of a phase II trial. J Clin Oncol 2009; 27 (Suppl): e15029.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Velenik, V.1    Ocvirk, J.2    Oblak, I.3
  • 74
    • 80053591096 scopus 로고    scopus 로고
    • Preoperative chemoradiation with cetuximab, irinotecan and capecitabine in patients with locally advanced resectable rectal cancer: A multicenter Phase II study
    • doi: 10.1016/j.ijrobp.2010. 06.035
    • Kim SY, Hong YS, Kim DY et al. Preoperative chemoradiation with cetuximab, irinotecan and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II study. Int J Radiat Oncol Biol Phys 2011; 81(3): 677-683. doi: 10.1016/j.ijrobp.2010. 06.035.
    • (2011) Int J Radiat Oncol Biol Phys , vol.81 , Issue.3 , pp. 677-683
    • Kim, S.Y.1    Hong, Y.S.2    Kim, D.Y.3
  • 75
    • 80155136973 scopus 로고    scopus 로고
    • Phase II study of panitumumab, oxaliplatin, 5-fluorouracil, and concurrent radiotherapy as preoperative treatment in high-risk locally advanced rectal cancer patients (StarPan/STAR-02 Study)
    • doi: 10.1093/annonc/mdq782
    • Pinto C, Di Fabio F, Maiello E et al. Phase II study of panitumumab, oxaliplatin, 5-fluorouracil, and concurrent radiotherapy as preoperative treatment in high-risk locally advanced rectal cancer patients (StarPan/STAR-02 Study). Ann Oncol 2011; 22(11): 2424-2430. doi: 10.1093/annonc/mdq782.
    • (2011) Ann Oncol , vol.22 , Issue.11 , pp. 2424-2430
    • Pinto, C.1    Di Fabio, F.2    Maiello, E.3
  • 76
    • 74049108229 scopus 로고    scopus 로고
    • Moleculary response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer
    • doi: 10.1200/JCO.2008.18.5033
    • Debucquoy A, Haustermans K, Daemen A et al. Moleculary response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer. J Clin Oncol 2009; 27(14): 2751-2757. doi: 10.1200/JCO.2008.18.5033.
    • (2009) J Clin Oncol , vol.27 , Issue.14 , pp. 2751-2757
    • Debucquoy, A.1    Haustermans, K.2    Daemen, A.3
  • 77
    • 61649088414 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene copy number, K-ras station and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer
    • doi: 10.1093/annonc/mdn647
    • Bengala C, Bettelli S, Bertolini F et al. Epidermal growth factor receptor gene copy number, K-ras station and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer. Ann Oncol 2009; 20(3): 469-474. doi: 10.1093/annonc/mdn647.
    • (2009) Ann Oncol , vol.20 , Issue.3 , pp. 469-474
    • Bengala, C.1    Bettelli, S.2    Bertolini, F.3
  • 78
    • 0033635827 scopus 로고    scopus 로고
    • Specific c-K-ras gene mutations as a tumor-response marker in locally advanced rectal cancer trated with preoperative chemoradiotherapy
    • Luna-Pérez P, Segura J, Alvarado I et al. Specific c-K-ras gene mutations as a tumor-response marker in locally advanced rectal cancer trated with preoperative chemoradiotherapy. Ann Surg Oncol 2000; 7(10): 727-731.
    • (2000) Ann Surg Oncol , vol.7 , Issue.10 , pp. 727-731
    • Luna-Pérez, P.1    Segura, J.2    Alvarado, I.3
  • 79
    • 0032945388 scopus 로고    scopus 로고
    • K-ras and p53 mutations and overexpressions as prognostic factors in fiale rectal carcinoma
    • Hirvikoski P, Auvinen A, Cummings B et al. K-ras and p53 mutations and overexpressions as prognostic factors in fiale rectal carcinoma. Anticancer Res 1999; 19(1 B): 685-691.
    • (1999) Anticancer Res , vol.19 , Issue.1 B , pp. 685-691
    • Hirvikoski, P.1    Auvinen, A.2    Cummings, B.3
  • 80
    • 84859403854 scopus 로고    scopus 로고
    • Effect of oxaliplatine, fluorouracil, and leucovorine with or without cetuximab on survival among patients with resected stage III colon cancer: A randomised trial
    • doi: 10.1001/jama.2012.385
    • Alberts SR, Sargent DJ, Nair S et al. Effect of oxaliplatine, fluorouracil, and leucovorine with or without cetuximab on survival among patients with resected stage III colon cancer: a randomised trial. JAMA 2012; 307(13): 1383-1393. doi: 10.1001/jama.2012.385.
    • (2012) JAMA , vol.307 , Issue.13 , pp. 1383-1393
    • Alberts, S.R.1    Sargent, D.J.2    Nair, S.3
  • 81
    • 36248944183 scopus 로고    scopus 로고
    • Cancer molecular imaging: Radionuclide-based biomarkers of the epidermal growth factor receptor (EGFR)
    • DOI 10.2174/156802607782507457
    • Mishani E, Abourbeh G. Cancer molecular imaging: radionuclide-based biomarkers of the epidermal growth factor receptor (EGFR). Curr Top Med Chem 2007; 7(18): 1755-1772. (Pubitemid 350130995)
    • (2007) Current Topics in Medicinal Chemistry , vol.7 , Issue.18 , pp. 1755-1772
    • Mishani, E.1    Abourbeh, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.