A scalable route to the SMO receptor antagonist SEN826: Benzimidazole synthesis via enhanced in situ formation of the bisulfite-aldehyde complex

Organic Process Research and Development

Volumn 18, Issue 6, 2014, Pages 699-708

  Betti, Matteo ^a   Genesio, Eva ^a   Marconi, Guido ^d   Sanna Coccone, Salvatore ^c   Wiedenau, Paul ^b  

^a Siena Biotech SpA   (Italy)

^b Aptuit Inc   (United States)

^c NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^d Novartis Vaccines ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMISTRY;

BENZIMIDAZOLE SYNTHESIS; GRAM QUANTITIES; IN-SITU FORMATIONS; RECEPTOR ANTAGONISTS; REDUCING COSTS; SYNTHETIC PROCEDURES; TARGET MOLECULE;

ALDEHYDES;

EID: 84903197207     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op4002092     Document Type: Article

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