Amide bond formation using an air-stable source of AlMe3

Tetrahedron Letters

Volumn 47, Issue 32, 2006, Pages 5767-5769

  Novak, Andrew ^a   Humphreys, Luke D ^b   Walker, Matthew D ^b   Woodward, Simon ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAZABICYCLO[2.2.2]OCTANE; ALUMINUM DERIVATIVE; AMIDE; ESTER DERIVATIVE; OXYGEN; SOLVENT;

AIR; ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; SYNTHESIS;

EID: 33745613776     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.06.004     Document Type: Article

References (18)

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15. Reactions to form secondary amides, including Weinreb amides, do not give acceptable yields under the present procedure.
16. 3 amide coupling yields became unacceptable.
17. Reaction performed as in the general procedure using standard undried glassware and all stages carried out in air. Lower specification grades of THF (containing up to 0.05% w/w water) were used directly from the bottle as supplied without the need for pre-drying.
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