Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer

Oncology Reports

Volumn 32, Issue 1, 2014, Pages 395-402

  Wu, Z E Hua ^a   Wang, Xiao Liang ^a   Tang, Hua Mei ^a   Jiang, Tao ^a   Chen, Jian ^a   Lu, S U ^a   Qiu, Guo Qiang ^a   Peng, Zhi Hai ^a   Yan, Dong Wang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Colon cancer; Epithelial mesenchymal transition; HOTAIR; LncRNA; Metastasis

Indexed keywords

GELATINASE B; HOX TRANSCRIPT ANTISENSE INTERGENIC RNA; LONG UNTRANSLATED RNA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; HOTAIR LONG UNTRANSLATED RNA, HUMAN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CELL MIGRATION; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE MARKER; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE; TUMOR INVASION; VERY ELDERLY; CELL MOTION; COLON TUMOR; DISEASE COURSE; DISEASE FREE SURVIVAL; GENETICS; LYMPH NODE METASTASIS; MIDDLE AGED; PATHOLOGY; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; CELL MOVEMENT; COLONIC NEOPLASMS; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; RNA, LONG NONCODING; UP-REGULATION;

EID: 84903195388     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3186     Document Type: Article

References (23)

1. NCCN Clinical Practice Guidelines in Oncology for Colon Cancer (Version 3). 2013. [EB/OL] Available at http://www.nccn.org/professionals/physician-gls/ f-guidelines.asp
2. Li M and Gu J: Changing patterns of colorectal cancer in China over a period of 20 years. World J Gastroenterol 11: 4685-4688, 2005. (Pubitemid 41179523)
3. Fearon ER: Molecular genetics of colorectal cancer. Annu Rev Pathol 6: 479-507, 2011.
4. Ulitsky I and Bartel DP: lincRNAs: genomics, evolution, and mechanisms. Cell 154: 26-46, 2013.
5. Gupta RA, Shah N, Wang KC, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464: 1071-1076, 2010.
6. Yang Z, Zhou L, Wu LM, et al: Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol 18: 1243-1250, 2011.
7. Lu L, Zhu G, Zhang C, et al: Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer. Breast Cancer Res Treat 136: 875-883, 2012.
8. Niinuma T, Suzuki H, Nojima M, et al: Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. Cancer Res 72: 1126-1136, 2012.
9. Kim K, Jutooru I, Chadalapaka G, et al: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 32: 1616-1625, 2013.
10. Li D, Feng J, Wu T, et al: Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. Am J Pathol 182: 64-70, 2013.
11. Nakagawa T, Endo H, Yokoyama M, et al: Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophys Res Commun 436: 319-324, 2013.
12. Zhuang Y, Wang X, Nguyen HT, et al: Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. J Hematol Oncol 6: 35, 2013.
13. Kogo R, Shimamura T, Mimori K, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res 71: 6320-6326, 2011.
14. Rinn JL, Kertesz M, Wang JK, et al: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129: 1311-1323, 2007. (Pubitemid 46962090)
15. Tsai MC, Manor O, Wan Y, et al: Long noncoding RNA as modular scaffold of histone modification complexes. Science 329: 689-693, 2010.
16. Sparmann A and van Lohuizen M: Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6: 846-856, 2006. (Pubitemid 44629896)
17. Richly H, Aloia L and Di Croce L: Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis 2: e204, 2011.
18. Crea F, Fornaro L, Bocci G, et al: EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis. Cancer Metastasis Rev 31: 753-761, 2012.
19. Ding J, Zhang ZM, Xia Y, et al: LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer. Br J Cancer 109: 994-1003, 2013.
20. Huang Z, Li S, Song W, et al: Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1). PLoS One 8: e70077, 2013.
21. Tang M, Shen H, Jin Y, et al: The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition. J Biol Chem 288: 27680-27691, 2013.
22. Abdel-Wahab O and Dey A: The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics. Leukemia 27: 10-15, 2013.
23. Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.