Monocytes activate natural killer cells via inflammasome-induced interleukin 18 in response to hepatitis C virus replication

Gastroenterology

Volumn 147, Issue 1, 2014, Pages

  Serti, Elisavet ^a   Werner, Jens M ^a   Chattergoon, Michael ^b   Cox, Andrea L ^b   Lohmann, Volker ^c   Rehermann, Barbara ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cytokine Production; Hepatocyte; Immune Response; Viral Replication

Indexed keywords

CD14 ANTIGEN; GAMMA INTERFERON; INFLAMMASOME; INTERLEUKIN 18; LUCIFERASE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIVIRAL ACTIVITY; ARTICLE; BLOOD DONOR; CELL FUNCTION; CELL ISOLATION; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; LYMPHOCYTOTOXICITY; MALE; MIDDLE AGED; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REPLICON; T LYMPHOCYTE ACTIVATION; TUMOR CELL CULTURE; TUMOR IMMUNITY; VIRUS REPLICATION;

CYTOKINE PRODUCTION; HEPATOCYTE; IMMUNE RESPONSE; VIRAL REPLICATION;

CELL COMMUNICATION; CELL LINE, TUMOR; COCULTURE TECHNIQUES; HEPACIVIRUS; HEPATITIS C, CHRONIC; HEPATOCYTES; HUMANS; INFLAMMASOMES; INTERFERON-GAMMA; INTERLEUKIN-18; KILLER CELLS, NATURAL; LIVER NEOPLASMS; MONOCYTES; VIRUS REPLICATION;

EID: 84903180205     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.03.046     Document Type: Article

References (29)

1. E. Vivier, D.H. Raulet, A. Moretta, M.A. Caligiuri, L. Zitvogel, L.L. Lanier, W.M. Yokoyama, and S. Ugolini Innate or adaptive immunity? The example of natural killer cells Science 331 2011 44 49
2. G. Ahlenstiel, R.H. Titerence, and C. Koh et al. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa- dependent manner Gastroenterology 138 2010 325 335
3. B. Oliviero, S. Varchetta, and E. Paudice et al. Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections Gastroenterology 137 2009 1151 1160
4. B. Rehermann Pathogenesis of chronic viral hepatitis: Differential roles of T cells and NK cells Nat Med 19 2013 859 868
5. M. Frese, V. Schwarzle, and K. Barth et al. Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs Hepatology 35 2002 694 703
6. A.I. Su, J.P. Pezacki, and L. Wodicka et al. Genomic analysis of the host response to hepatitis C virus infection Proc Natl Acad Sci U S A 99 2002 15669 15674
7. E.C. Shin, U. Seifert, and T. Kato et al. Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection J Clin Invest 116 2006 3006 3014
8. S. Crotta, A. Stilla, and A. Wack et al. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein J Exp Med 195 2002 35 41
9. C.T. Tseng, and G.R. Klimpel Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions J Exp Med 195 2002 43 49
10. S. Crotta, M. Brazzoli, and D. Piccioli et al. Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection J Hepatol 52 2010 183 190
11. J.C. Yoon, M. Shiina, and G. Ahlenstiel et al. Natural killer cell function is intact after direct exposure to infectious hepatitis C virions Hepatology 49 2009 12 21
12. J.C. Yoon, J.B. Lim, and J.H. Park et al. Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells J Virol 85 2011 12557 12569
13. K.C. Newman, D.S. Korbel, and J.C. Hafalla et al. Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-gamma responses to malaria PLoS Pathog 2 2006 e118
14. S. Zhang, B. Saha, and K. Kodys et al. IFN-gamma production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells J Hepatol 59 2013 442 449
15. J. Jo, U. Aichele, and N. Kersting et al. Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model Gastroenterology 136 2009 1391 1401
16. H. Park, E. Serti, and O. Eke et al. IL-29 Is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection Hepatology 56 2012 2060 2070
17. J. Cros, N. Cagnard, and K. Woollard et al. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors Immunity 33 2010 375 386
18. M.G. Netea, C.A. Nold-Petry, and M.F. Nold et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages Blood 113 2009 2324 2335
19. S. Marukian, C.T. Jones, and L. Andrus et al. Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells Hepatology 48 2008 1843 1850
20. H. Wedemeyer, X.S. He, and M. Nascimbeni et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection J Immunol 169 2002 3447 3458
21. B. Seigel, B. Bengsch, and V. Lohmann et al. Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo Gastroenterology 144 2013 426 436
22. E. Mortier, T. Woo, and R. Advincula et al. IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation J Exp Med 205 2008 1213 1225
23. A.A. Negash, H.J. Ramos, and N. Crochet et al. IL-1beta production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease PLoS Pathog 9 2013 e1003330
24. D. Ferrari, P. Chiozzi, and S. Falzoni et al. Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin J Exp Med 185 1997 579 582
25. V. Petrilli, S. Papin, and C. Dostert et al. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration Cell Death Differ 14 2007 1583 1589
26. K. Takahashi, S. Asabe, and S. Wieland et al. Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection Proc Natl Acad Sci U S A 107 2010 7431 7436
27. M. Dreux, U. Garaigorta, and B. Boyd et al. Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity Cell Host Microbe 12 2012 558 570
28. T. Pietschmann, V. Lohmann, and A. Kaul et al. Persistent and transient replication of full-length hepatitis C virus genomes in cell culture J Virol 76 2002 4008 4021
29. M.A. Chattergoon, J.S. Levine, and R. Latanich et al. High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection J Infect Dis 204 2011 1730 1740