Promoter hypermethylation influences the suppressive role of maternally expressed 3, a long non-coding RNA, in the development of epithelial ovarian cancer

Oncology Reports

Volumn 32, Issue 1, 2014, Pages 277-285

  Sheng, Xiujie ^a,b   Li, Jianqi ^a,b   Yang, Lei ^a   Chen, Zhiyi ^b   Zhao, Qin ^a   Tan, Linyu ^a   Zhou, Yanqing ^a   Li, Juan ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b Guangzhou Institute of Obstetrics and Gynecology   (China)

Author keywords

Epithelial ovarian cancer; Long non coding RNA; Maternally expressed 3; Methylation

Indexed keywords

LONG UNTRANSLATED RNA; MATERNALLY EXPRESSED 3; PROTEIN P53; UNCLASSIFIED DRUG; 5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; MEG3 NON-CODING RNA, HUMAN; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MATERNALLY EXPRESSED 3 GENE; MITOSIS INHIBITION; MOLECULAR PATHOLOGY; MTT ASSAY; OVARY CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; NEOPLASM; OVARY; OVARY TUMOR; PATHOLOGY; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

AZACITIDINE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; OVARY; PROMOTER REGIONS, GENETIC; RNA, LONG NONCODING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84903174044     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3208     Document Type: Article

References (25)

1. Itamochi H: Targeted therapies in epithelial ovarian cancer: molecular mechanisms of action. World J Biol Chem 1: 209-220, 2010.
2. Gibb EA, Brown CJ and Lam WL: The functional role of long non-coding RNA in human carcinomas. Mol Cancer 10: 38, 2011.
3. Miyoshi N, Wagatsuma H, Wakana S, et al: Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cell 5: 211-220, 2000. (Pubitemid 30227843)
4. Zhang X, Zhou Y, Mehta KR, et al: A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. J Clin Endocrinol Metab 88: 5119-5126, 2003. (Pubitemid 37452705)
5. Zhou Y, Zhang X and Klibanski A: MEG3 noncoding RNA: a tumor suppressor. J Mol Endocrinol 48: R45-R53, 2012.
6. Zhao J, Dahle D, Zhou Y, Zhang X and Klibanski A: Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. J Clin Endocrinol Metab 90: 2179-2186, 2005. (Pubitemid 40586259)
7. Zhang X, Gejman R, Mahta A, et al: Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70: 2350-2358, 2010.
8. Astuti D, Latif F, Wagner K, et al: Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour. Br J Cancer 92: 1574-1580, 2005. (Pubitemid 40705027)
9. Zhou Y, Zhong Y, Wang Y, et al: Activation of p53 by MEG3 non-coding RNA. J Biol Chem 282: 24731-24742, 2007. (Pubitemid 47347547)
10. Braconi C, Kogure T, Valeri N, et al: microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene 30: 4750-4756, 2011.
11. Wang P, Ren Z and Sun P: Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. J Cell Biochem 113: 1868-1874, 2012.
12. Benetatos L, Hatzimichael E, Dasoula A, et al: CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes. Leuk Res 34: 148-153, 2010.
13. Feng S, Cong S, Zhang X, et al: MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Res 39: 6669-6678, 2011.
14. Anwar SL, Krech T, Hasemeier B, et al: Loss of imprinting and allelic switching at the DLK1-MEG3 locus in human hepatocellular carcinoma. PLoS One 7: e49462, 2012.
15. Benetatos L, Vartholomatos G and Hatzimichael E: MEG3 imprinted gene contribution in tumorigenesis. Int J Cancer 129: 773-779, 2011.
16. Kagami M, O'Sullivan MJ, Green AJ, et al: The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers. PLoS Genet 6: e1000992, 2010.
17. Jones PA and Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428, 2002. (Pubitemid 34587077)
18. Baylin SB and Ohm JE: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6: 107-116, 2006. (Pubitemid 43361543)
19. Yoon JH, Dammann R and Pfeifer GP: Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas. Int J Cancer 94: 212-217, 2001. (Pubitemid 32911415)
20. Ibanez de Caceres I, Battagli C, Esteller M, et al: Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res 64: 6476-6481, 2004. (Pubitemid 39297903)
21. Chan KY, Ozçelik H, Cheung AN, Ngan HY and Khoo US: Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer. Cancer Res 62: 4151-4156, 2002. (Pubitemid 34791087)
22. Kim T, Veronese A, Pichiorri F, et al: p53 regulates epithelial- mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med 208: 875-883, 2011.
23. Huarte M, Guttman M, Feldser D, et al: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142: 409-419, 2010.
24. Brooks CL and Gu W: p53 regulation by ubiquitin. FEBS Lett 585: 2803-2809, 2011.
25. Staub J, Chien J, Pan Y, et al: Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance. Oncogene 26: 4969-4978, 2007. (Pubitemid 47172647)