Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: A naturalistic comparison of cognitive performance relative to healthy controls

BMC Clinical Pharmacology

Volumn 7, Issue , 2007, Pages

  Rapeli, Pekka ^a,b,c   Fabritius, Carola ^b   Alho, Hannu ^b,c   Salaspuro, Mikko ^b,c   Wahlbeck, Kristian ^d   Kalska, Hely ^c  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d VAASA CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMPHETAMINE; ANXIOLYTIC AGENT; BENZODIAZEPINE; BUPRENORPHINE; BUPRENORPHINE PLUS NALOXONE; CANNABIS; CHLORPROMAZINE; CITALOPRAM; DIAMORPHINE; DIAZEPAM; DOXEPIN; ESCITALOPRAM; FLUOXETINE; FLUPENTIXOL; HYDROXYZINE; IBUPROFEN; LEVOMEPROMAZINE; METHADONE; MIRTAZAPINE; NICOTINE; OPIATE; OXAZEPAM; PAROXETINE; QUETIAPINE; SERTRALINE; UNINDEXED DRUG; VENLAFAXINE; ZOLPIDEM; ZOPICLONE; NALOXONE;

ADULT; ALCOHOLISM; AMNESIA; ANALYSIS OF VARIANCE; ARTICLE; ATTENTION; ATTENTION DISTURBANCE; CANNABIS ADDICTION; CLINICAL ARTICLE; COGNITION; COMORBIDITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DEPENDENCE; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; FINLAND; HEROIN DEPENDENCE; HUMAN; LEARNING; LOW DRUG DOSE; MALE; NATURALISTIC INQUIRY; NEUROPSYCHOLOGICAL TEST; OPIATE ADDICTION; REACTION TIME; RECALL; TOBACCO DEPENDENCE; TREATMENT OUTCOME; VERBAL MEMORY; WITHDRAWAL SYNDROME; WORKING MEMORY; CHEMICALLY INDUCED DISORDER; COGNITIVE DEFECT; COMPARATIVE STUDY; DRUG COMBINATION; DRUG EFFECT; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

ADULT; BUPRENORPHINE; COGNITION; COGNITION DISORDERS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; METHADONE; NALOXONE; OPIOID-RELATED DISORDERS; REACTION TIME;

EID: 34547845288     PISSN: None     EISSN: 14726904     Source Type: Journal    
DOI: 10.1186/1472-6904-7-5     Document Type: Article

References (56)

1. Alho H Sinclair D Vuori E Holopainen A Abuse liability of buprenorphine-naloxone tablets in untreated IV drug users Drug and Alcohol Dependence 2007 88 75-78 10.1016/j.drugalcdep.2006.09.012
2. Report of the International Narcotics Control Board for 2006 http://www.incb.org/incb/annual_report_2006.html
3. Comer SD Walker EA Collins ED Buprenorphine/naloxone reduces the reinforcing and subjective effects of heroin in heroin-dependent volunteers Psychopharmacology (Berl) 2005 181 664-675 10.1007/ s00213-005-0023-6 16025322
4. Harris DS Mendelson JE Lin ET Upton RA Jones RT Pharmacokinetics and subjective effects of sublingual buprenorphine, alone or in combination with naloxone - Lack of dose proportionality Clin Pharmacokinet 2004 43 329-340 10.2165/00003088-200443050-00005 15080765
5. Strain EC Stitzer ML Liebson IA Bigelow GE Methadone Dose and Treatment Outcome Drug and Alcohol Dependence 1993 33 105-117 10.1016/ 0376-8716(93)90052-R
6. Strang J Finch E Hankinson L Farrell M Taylor C Gossop M Methadone treatment for opiate addiction: Benefits in the first month Addiction Research 1997 5 71-76
7. Fiorentine R Nakashima J Anglin MD Client Engagement in Drug Treatment Journal of Substance Abuse Treatment 1999 17 199-206 10.1016/ S0740-5472(98)00076-2 10531626
8. Gossop M Stewart D Marsden J Treatment process components and heroin use outcome among methadone patients Drug and Alcohol Dependence 2003 71 93-102 10.1016/S0376-8716(03)00067-X
9. Zacny JP Conley K Galinkin J Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Buprenorphine and Morphine in Healthy Volunteers J Pharmacol Exp Ther 1997 282 1187-1197 9316825
10. Zacny JP A Review of the Effects of Opioids on Psychomotor and Cognitive Functioning in Humans Exp Clinic Psychopharmacol 1995 3 432-466 10.1037/ 1064-1297.3.4.432
11. Rothenberg S Schottenfeld S Meyer RE Krauss B Gross K Performance differences between addicts and non-addicts Psychopharmacology (Berl) 1977 52 299-306 10.1007/BF00426715 406634
12. Curran HV Kleckham J Bearn J Strang J Wanigaratne S Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: A dose-response study Psychopharmacology (Berl) 2001 154 153-160 10.1007/ s002130000628 11314677
13. Curran HV Bolton J Wanigaratne S Smyth C Additional methadone increases craving for heroin: A double-blind, placebo-controlled study of chronic opiate users receiving methadone substitution treatment Addiction 1999 94 665-674 10.1046/j.1360-0443.1999.9456654.x 10563031
14. Soyka M Horak M Dittert S Kagerer S Less driving impairment on buprenorphine than methadone in drug-dependent patients? J Neuropsychiatry Clin Neurosci 2001 13 527-528 11748323
15. Soyka M Hock B Kagerer S Lehnert R Limmer C Kuefner H Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients - Results of a randomized clinical trial J Clin Psychopharmacol 2005 25 490-493 10.1097/01.jcp.0000178417.60426.60 16160628
16. Pirastu R Fais R Messina M Bini V Spiga S Falconieri D Diana M Impaired decision-making in opiate-dependent subjects: Effect of pharmacological therapies Drug Alcohol Depend 2006 83 163-168 10.1016/ j.drugalcdep.2005.11.008 16343811
17. Gossop M Stewart D Browne N Marsden J Methadone treatment for opiate dependent patients in general practice and specialist clinic settings: Outcomes at 2-year follow-up J Subst Abuse Treat 2003 24 313-321 10.1016/ S0740-5472(03)00040-0 12867205
18. Virtanen A Salaspuro M Partanen A Kaukonen O Kinnunen A National Report to the EMCDDA by the Finnish National Focal Point-Drugs in Finland http://ar2005.emcdda.eu.int/en/home-en.html
19. Koob GF Drugs of abuse: Anatomy, pharmacology and function of reward pathways Trends Pharmacol Sci 1992 13 177-184 10.1016/ 0165-6147(92)90060-J 1604710
20. Ashton H The diagnosis and management of benzodiazepine dependence Curr Opin Psychiatry 2005 18 249-255 10.1097/01.yco.0000165594.60434.84 16639148
21. Zimmermann P Fimm B Test for Attentional Performance (TAP) Herzogenrath, PsyTest 1995
22. Sturm W de Simone A Krause BJ Specht K Hesselmann V Radermacher I Herzog H Tellmann L Muller-Gartner HW Willmes K Functional anatomy of intrinsic alertness: Evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere Neuropsychologia 1999 37 797-805 10.1016/ S0028-3932(98)00141-9 10408647
23. Rubia K Russell T Overmeyer S Brammer MJ Bullmore ET Sharma T Simmons A Williams SCR Giampietro V Andrew CM Taylor E Mapping motor inhibition: Conjunctive brain activations across different versions of go/no-go and stop tasks Neuroimage 2001 13 250-261 10.1006/nimg.2000.0685 11162266
24. Posner MI Sheese BE Odludas Y Tang YY Analyzing and shaping human attentional networks Neural Networks 2006 19 1422-1429 10.1016/ j.neunet.2006.08.004 17059879
25. Wecshler D Wechsler Memory Scale - Revised (WMS-R). Finnish version Helsinki, Psykologien kustannus 1996
26. Gronwall DM Paced auditory serial-addition task: A measure of recovery from concussion Percept Mot Skills 1977 44 367-373 866038
27. Koskinen SK Sarajuuri JM Computer-administered cognitive remediation in a frame of holistic neuropsychological rehabilitation: FORAMENrehab programs Acta Neurochir (Wien) 2002 144 A20-A21
28. Lezak M Neuropsychological Assesment New York, Oxford University Press 1995
29. Kaitaro T Koskinen S Kaipio ML Neuropsychological problems in everyday life: A 5-year follow-up study of young severely closed-head-injured patients Brain Inj 1995 9 713-727 8680398
30. Lynskey M Hall W The effects of adolescent cannabis use on educational attainment: A review Addiction 2000 95 1621-1630 10.1046/ j.1360-0443.2000.951116213.x 11219366
31. Der G Deary IJ IQ, reaction time and the differentiation hypothesis Intelligence 2003 31 491-503 10.1016/S0160-2896(02)00189-7
32. Effect Size Calculator http://www.cemcentre.org/renderpage.asp?linkID= 25017
33. Rapeli P Kivisaari R Autti T Kahkonen S Puuskari V Jokela O Kalska H Cognitive function during early abstinence from opioid dependence: A comparison to age, gender, and verbal intelligence matched controls. BMC Psychiatry 6 9 2006 Feb 24 1489929 16504127 10.1186/1471-244X-6-9
34. Verdejo-Garcia A Lopez-Torrecillas F Gimenez CO Perez-Garcia M Clinical implications and methodological challenges in the study of the neuropsychological correlates of cannabis, stimulant, and opioid abuse Neuropsychol Rev 2004 14 1-41 10.1023/B:NERV.0000026647.71528.83 15260137
35. Darke S Sims J McDonald S Wickes W Cognitive impairment among methadone maintenance patients Addiction 2000 95 687-695 10.1046/ j.1360-0443.2000.9556874.x 10885043
36. Specka M Finkbeiner T Lodemann E Leifert K Kluwig J Gastpar M Cognitive-motor performance of methadone-maintained patients Eur Addict Res 2000 6 8-19 10.1159/000019004 10729738
37. Haut MW Kuwabara H Leach S Arias RG Neural Activation During Performance of Number-Letter Sequencing Applied Neuropsychology 2000 7 237-242 10.1207/S15324826AN0704_5 11296686
38. Lockwood AH Linn RT Szymanski H Coad ML Wack DS Mapping the neural systems that mediate the Paced Auditory Serial Addition Task (PASAT) J Int Neuropsychol Soc 2004 10 26-34 10.1017/S1355617704101045 14751004
39. Pezawas L Fischer G Podreka I Schindler S Brucke T Jagsch R Thurnher M Kasper S Opioid addiction changes cerebral blood flow symmetry Neuropsychobiology 2002 45 67-73 10.1159/000048679 11893862
40. Walsh SL Gilson SF Jasinski DR Stapleton JM Phillips RL Dannals RF Schmidt J Preston KL Grayson R Bigelow GE Sullivan JT Contoreggi C London ED Buprenorphine Reduces Cerebral Glucose-Metabolism in Polydrug Abusers Neuropsychopharmacology 1994 10 157-170 7916913
41. Zamani R Semnanian S Fathollahi Y Hajizadeh S Systemic naloxone enhances cerebral blood flow in anesthetized morphine-dependent rats European Journal of Pharmacology 2000 408 299-304 10.1016/S0014-2999(00)00794-9 11090647
42. Silveri MM Pollack MH Diaz CI Nassar LE Mendelson JH Yurgelun-Todd DA Renshaw PF Kaufman MJ Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment Psychiatry Research-Neuroimaging 2004 131 217-226 10.1016/j.pscychresns.2004.05.003
43. Arnsten AFT Catecholamine modulation of prefrontal cortical cognitive function Trends Cogn Sci 1998 2 436-447 10.1016/S1364-6613(98)01240-6
44. Hepner IJ Homewood J Taylor AJ Methadone disrupts performance on the working memory version of the Morris water task Physiology & Behavior 2002 76 41-49 10.1016/S0031-9384(02)00695-9 12175587
45. Liao D Lin H Law PY Loh HH Mu-opioid receptors modulate the stability of dendritic spines PNAS 2005 102 1725-1730 545084 15659552 10.1073/ pnas.0406797102
46. Eisch AJ Barrot M Schad CA Self DW Nestler EJ Opiates inhibit neurogenesis in the adult rat hippocampus PNAS 2000 97 7579-7584 16588 10840056 10.1073/pnas.120552597
47. Barker MJ Greenwood KM Jackson M Crowe SF Cognitive effects of long-term benzodiazepine use: A meta-analysis CNS Drugs 2004 18 37-48 10.2165/ 00023210-200418010-00004 14731058
48. Voshaar RCO Verkes RJ van Luijtelaar G Edelbroek PM Zitman FG Effects of additional oxazepam in long-term users of oxazepam J Clin Psychopharmacol 2005 25 42-50 10.1097/01.jcp.0000150219.59056.d0 15643099
49. Lintzeris N Mitchell TB Bond A Nestor L Strang J Interactions on mixing diazepam with methadone or buprenorphine in maintenance patients J Clin Psychopharmacol 2006 26 274-283 10.1097/01.jcp.0000219050.33008.61 16702892
50. Gordon NB Reaction-times of methadone treated ex heroin addicts Psychopharmacology (Berl) 1970 V16 337-344 10.1007/BF00404740
51. Goetz DW Jacobson JM Murnane JE Reid MJ Repperger DW Goodyear C Martin ME Prolongation of simple and choice reaction times in a double-blind comparison of twice-daily hydroxyzine versus terfenadine J Allergy Clin Immunol 1989 84 316-322 10.1016/0091-6749(89)90414-4 2570798
52. Meador KJ Loring DW Moore EE Thompson WO Nichols ME Oberzan RE Durkin MW Gallagher BB King DW Comparative cognitive effects of phenobarbital, phenytoin, and valproate in healthy adults Neurology 1995 45 1494-1499 7644047
53. Meador KJ Cognitive side effects of medications Neurol Clin 1998 16 141-155 10.1016/S0733-8619(05)70371-6 9421545
54. Terzano MG Rossi M Palomba V Smerieri A Parrino L New drugs for insomnia - Comparative tolerability of zopiclone, zolpidem and zaleplon Drug Safety 2003 26 261-282 10.2165/00002018-200326040-00004 12608888
55. Barker MJ Greenwood KM Jackson M Crowe SF Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: A meta-analysis Arch Clin Neuropsychol 2004 19 437-454 10.1016/ S0887-6177(03)00096-9 15033227
56. Fried PA Watkinson B Gray R Neurocognitive consequences of cigarette smoking in young adults - a comparison with pre-drug performance Neurotoxicol Teratol 2006 28 517-525 10.1016/j.ntt.2006.06.003 16904287