Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide

Free Radical Biology and Medicine

Volumn 73, Issue , 2014, Pages 291-298

  Samuni, Yuval ^a,b   Wink, David A ^c   Krishna, Murali C ^c   Mitchell, James B ^c   Goldstein, Sara ^d  

^a DEAKIN UNIVERSITY   (Australia)

^b BARZILAI MEDICAL CENTER   (Israel)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Free radicals; HNO; Kinetics; Nitroxide; NO; Pulse radiolysis; SAHA; Tempol; Valproic acid

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE DONOR; TEMPOL; VALPROIC ACID; VORINOSTAT; AMINE OXIDE; ANTIOXIDANT; ENZYME INHIBITOR; H2AFX PROTEIN, HUMAN; HISTONE; HYDROGEN PEROXIDE; HYDROXAMIC ACID; METMYOGLOBIN; NITROGEN OXIDE; NITROXYL; RADIOSENSITIZING AGENT; SPIN LABELING;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HT 29 CELL LINE; HUMAN; HUMAN CELL; HYPOXIC CELL; IN VITRO STUDY; INCUBATION TIME; IRRADIATION; OXIDATION; PRIORITY JOURNAL; TUMOR CELL; UPREGULATION; BIOSYNTHESIS; CELL HYPOXIA; CHEMISTRY; DRUG EFFECTS; G1 PHASE CELL CYCLE CHECKPOINT; METABOLISM; NEOPLASMS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHYSIOLOGY; SPIN LABELING; TUMOR CELL LINE;

ANTIOXIDANTS; CELL HYPOXIA; CELL LINE, TUMOR; CYCLIC N-OXIDES; ENZYME INHIBITORS; G1 PHASE CELL CYCLE CHECKPOINTS; HISTONES; HT29 CELLS; HUMANS; HYDROGEN PEROXIDE; HYDROXAMIC ACIDS; METMYOGLOBIN; NEOPLASMS; NITRIC OXIDE; NITROGEN OXIDES; OXIDATION-REDUCTION; OXIDATIVE STRESS; RADIATION-SENSITIZING AGENTS; SPIN LABELS; VALPROIC ACID;

EID: 84903165069     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.05.019     Document Type: Article

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