Multikilogram-scale production of cycloartenol triterpenoid glycosides as synthetic intermediates for a γ-secretase modulator

Organic Process Research and Development

Volumn 18, Issue 6, 2014, Pages 676-682

  Shen, Ruichao ^a,c   Fuller, Nathan O ^a,d   Osswald, Gerd ^b   Austin, Wesley F ^a,e   Hubbs, Jed L ^a,f   Haag, Dieter ^b   Kovacs, Janos ^b   Creaser, Steffen P ^a,g   Findeis, Mark A ^a,h   Ives, Jeffrey L ^a   Bronk, Brian S ^a,i  

^a Satori Pharmaceuticals Incorporated   (United States)

^b Carbogen AMCIS AG   (Switzerland)

^c Enanta Pharmaceuticals Inc   (United States)

^d ASTRAZENECA   (United Kingdom)

^e Celgene Avilomics Research   (United States)

^f ETH ZURICH   (Switzerland)

^g GENZYME CORPORATION   (United States)

^h Resilientx Therapeutics   (United States)

ⁱ SANOFI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMISTRY;

ALZHEIMER'S DISEASE; EFFICIENT PROCESS; PROCESS DEVELOPMENT; REARRANGEMENT REACTIONS; SECRETASES; SYNTHETIC INTERMEDIATES; THERAPEUTIC AGENTS; TRITERPENOID GLYCOSIDES;

SUGARS;

EID: 84903159472     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op5000732     Document Type: Article

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