Momilactone B induces apoptosis and G1 arrest of the cell cycle in human monocytic leukemia U937 cells through downregulation of pRB phosphorylation and induction of the cyclin-dependent kinase inhibitor p21Waf1/Cip1

Oncology Reports

Volumn 31, Issue 4, 2014, Pages 1653-1660

  Park, Cheol ^a   Jeong, Na Young ^b   Kim, Gi Young ^c   Han, Min Ho ^a,d   Chung, Ill Min ^e   Kim, Wun Jae ^f   Yoo, Young Hyun ^b   Choi, Yung Hyun ^a,d  

^a Dong Eui University   (South Korea)

^b Dong A University College of Medicine   (South Korea)

^c Jeju National University   (South Korea)

^d Dong Eui University   (South Korea)

^e Konkuk University   (South Korea)

^f Chungbuk National University College of Medicine   (South Korea)

Author keywords

Apoptosis; G1 arrest; Momilactone B; P21; PRB; U937 cells

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; MOMILACTONE B; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTIC LEUKEMIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DITERPENES; DOWN-REGULATION; FLOW CYTOMETRY; HUMANS; IMMUNOPRECIPITATION; LACTONES; LEUKEMIA; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; U937 CELLS;

EID: 84903159193     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3008     Document Type: Article

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