Abnormal urinary excretion of NKCC2 and AQP2 in response to hypertonic saline in chronic kidney disease: An intervention study in patients with chronic kidney disease and healthy controls

BMC Nephrology

Volumn 15, Issue 1, 2014, Pages

  Jensen, Janni M ^a,b   Mose, Frank H ^a,b   Kulik, Anna Ewa O ^a,b   Bech, Jesper N ^a,b   Fenton, Robert A ^b   Pedersen, Erling B ^a,b  

^a HOLSTEBRO HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

AQP2; Chronic kidney disease; ENaC; NKCC2; Sodium; Water

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; AQUAPORIN 2; EPITHELIAL SODIUM CHANNEL; RENIN; SODIUM CHLORIDE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; AQP2 PROTEIN, HUMAN; SLC12A1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BODY FLUID; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FREE WATER CLEARANCE; GLOMERULUS FILTRATION RATE; HUMAN; IMMUNOASSAY; INTERVENTION STUDY; KIDNEY CLEARANCE; KIDNEY CONCENTRATING CAPACITY; MALE; MEASUREMENT; SODIUM ABSORPTION; URINALYSIS; URINARY EXCRETION; URINE VOLUME; ADOLESCENT; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFECTS; MICTURITION; MIDDLE AGED; PHYSIOLOGY; RENAL INSUFFICIENCY, CHRONIC; URINE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AQUAPORIN 2; CASE-CONTROL STUDIES; FEMALE; HUMANS; INTERVENTION STUDIES; MALE; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; SALINE SOLUTION, HYPERTONIC; SOLUTE CARRIER FAMILY 12, MEMBER 1; URINATION; YOUNG ADULT;

EID: 84902945589     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-15-101     Document Type: Article

References (53)

1. Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. Hayslett JP, Kashgarian M, Epstein FH, J Clin Invest 1969 48 6 1002 1006
2. Altered expression of Na transporters NHE-3, NaPi-II, Na-K-ATPase, BSC-1, and TSC in CRF rat kidneys. Kwon TH, Frokiaer J, Fernandez-Llama P, Maunsbach AB, Knepper MA, Nielsen S, Am J Physiol 1999 277 2 Pt 2 257 F270
3. Vasopressin-resistant hyposthenuria in advanced chronic renal disease. Tannen RL, Regal EM, Dunn MJ, Schrier RW, N Engl J Med 1969 280 21 1135 1141
4. Urinary concentration defect and limited expression of sodium cotransporter, rBSC1, in a rat model of chronic renal failure. Michimata M, Kazama I, Mizukami K, Araki T, Nakamura Y, Suzuki M, Wang W, Fujimori K, Satomi S, Ito S, Imai Y, Matsubara M, Nephron Physiol 2003 93 2 34 41
5. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. DiGiovanni SR, Nielsen S, Christensen EI, Knepper MA, Proc Natl Acad Sci U S A 1994 91 19 8984 8988
6. Urinary excretion of aquaporin-2 in patients with diabetes insipidus. Kanno K, Sasaki S, Hirata Y, Ishikawa S, Fushimi K, Nakanishi S, Bichet DG, Marumo F, N Engl J Med 1995 332 23 1540 1545
7. Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus. Deen PM, van Aubel RA, van Lieburg AF, van Os CH, J Am Soc Nephrol 1996 7 6 836 841 (Pubitemid 27465976)
8. Regulation and dysregulation of aquaporins in water balance disorders. Nielsen S, Kwon TH, Frokiaer J, Agre P, J Intern Med 2007 261 1 53 64 (Pubitemid 46046472)
9. Abnormal function of the vasopressin-cyclic-AMP-aquaporin2 axis during urine concentrating and diluting in patients with reduced renal function. A case control study. Pedersen EB, Thomsen IM, Lauridsen TG, BMC Nephrol 2010 11 26
10. Disorders of the epithelial Na(+) channel in Liddle's syndrome and autosomal recessive pseudohypoaldosteronism type 1. Oh YS, Warnock DG, Exp Nephrol 2000 8 6 320 325
11. Sodium transporters in the distal nephron and disease implications. Ecelbarger CA, Tiwari S, Curr Hypertens Rep 2006 8 2 158 165 (Pubitemid 43796694)
12. Molecular regulation of NKCC2 in the thick ascending limb. Ares GR, Caceres PS, Ortiz PA, Am J Physiol Renal Physiol 2011 301 6 1143 F1159
13. Detection of Na(+) transporter proteins in urine. McKee JA, Kumar S, Ecelbarger CA, Fernandez-Llama P, Terris J, Knepper MA, J Am Soc Nephrol 2000 11 11 2128 2132
14. Urinary measurement of Na+/H + exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF. du Cheyron D, Daubin C, Poggioli J, Ramakers M, Houillier P, Charbonneau P, Paillard M, Am J Kidney Dis 2003 42 3 497 506 (Pubitemid 37048125)
15. Sex and body-type interactions in the regulation of renal sodium transporter levels, urinary excretion, and activity in lean and obese Zucker rats. Riazi S, Madala-Halagappa VK, Hu X, Ecelbarger CA, Gend Med 2006 3 4 309 327 (Pubitemid 46917059)
16. Effect of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein renin ratio in patients with arterial hypertension and unilateral renal artery disease. Pedersen EB, Eiskjaer H, Madsen B, Danielsen H, Egeblad M, Nielsen CB, Nephrol Dial Transplant 1993 8 10 1064 1070 (Pubitemid 23322619)
17. Effect of water deprivation and hypertonic saline infusion on urinary AQP2 excretion in healthy humans. Pedersen RS, Bentzen H, Bech JN, Pedersen EB, Am J Physiol Renal Physiol 2001 280 5 860 F867
18. Effect of high and low sodium intake on urinary aquaporin-2 excretion in healthy humans. Graffe CC, Bech JN, Pedersen EB, Am J Physiol Renal Physiol 2012 302 2 264 F275
19. Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans. Lauridsen TG, Vase H, Starklint J, Bech JN, Pedersen EB, Nephrol Dial Transplant 2010 25 8 2502 2510
20. Effect of amiloride and spironolactone on renal tubular function and central blood pressure in patients with arterial hypertension during baseline conditions and after furosemide: a double-blinded, randomized, placebo-controlled crossover trial. Matthesen SK, Larsen T, Vase H, Lauridsen TG, Jensen JM, Pedersen EB, Clin Exp Hypertens 2013 35 5 313 324
21. Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney. Hager H, Kwon TH, Vinnikova AK, Masilamani S, Brooks HL, Frokiaer J, Knepper MA, Nielsen S, Am J Physiol Renal Physiol 2001 280 6 1093 F1106
22. Urinary aquaporin-2 in healthy humans and patients with liver cirrhosis and chronic heart failure during baseline conditions and after acute water load. Pedersen RS, Bentzen H, Bech JN, Nyvad O, Pedersen EB, Kidney Int 2003 63 4 1417 1425 (Pubitemid 36350006)
23. Abnormal increase in urinary aquaporin-2 excretion in response to hypertonic saline in essential hypertension. Graffe CC, Bech JN, Lauridsen TG, Vase H, Pedersen EB, BMC Nephrol 2012 13 15
24. Urinary excretion of AQP2 and ENaC in autosomal dominant polycystic kidney disease during basal conditions and after a hypertonic saline infusion. Graffe CC, Bech JN, Lauridsen TG, Pedersen EB, Am J Physiol Renal Physiol 2012 302 8 917 F927
25. Direct effect of methylprednisolone on renal sodium and water transport via the principal cells in the kidney. Lauridsen TG, Vase H, Bech JN, Nielsen S, Pedersen EB, Eur J Endocrinol 2010 162 5 961 969
26. Identification and proteomic profiling of exosomes in human urine. Pisitkun T, Shen RF, Knepper MA, Proc Natl Acad Sci U S A 2004 101 36 13368 13373 (Pubitemid 39209672)
27. Urinary excretion of aquaporin-2 in rat is mediated by a vasopressin-dependent apical pathway. Wen H, Frokiaer J, Kwon TH, Nielsen S, J Am Soc Nephrol 1999 10 7 1416 1429 (Pubitemid 29297516)
28. The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism. van der Lubbe N, Jansen PM, Salih M, Fenton RA, van den Meiracker AH, Danser AH, Zietse R, Hoorn EJ, Hypertension 2012 60 3 741 748
29. Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter (NCC) measurement. Isobe K, Mori T, Asano T, Kawaguchi H, Nonoyama S, Kumagai N, Kamada F, Morimoto T, Hayashi M, Sohara E, Rai T, Sasaki S, Uchida S, Am J Physiol Renal Physiol 2013 305 9 1374
30. Regulation of the epithelial sodium channel by membrane trafficking. Butterworth MB, Edinger RS, Frizzell RA, Johnson JP, Am J Physiol Renal Physiol 2009 296 1 10 F24
31. Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. Gimenez I, Forbush B, J Biol Chem 2003 278 29 26946 26951 (Pubitemid 36876847)
32. The physiology of urinary concentration: an update. Sands JM, Layton HE, Semin Nephrol 2009 29 3 178 195
33. Regulation of the sodium transporters NHE3, NKCC2 and NCC in the kidney. Knepper MA, Brooks HL, Curr Opin Nephrol Hypertens 2001 10 5 655 659 (Pubitemid 32783817)
34. Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Kim GH, Ecelbarger CA, Mitchell C, Packer RK, Wade JB, Knepper MA, Am J Physiol 1999 276 1 Pt 2 96 F103
35. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V, Am J Pathol 2013 182 1 96 106
36. cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP. Ortiz PA, Am J Physiol Renal Physiol 2006 290 3 608 F616
37. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Simon DB, Karet FE, Hamdan JM, DiPietro A, Sanjad SA, Lifton RP, Nat Genet 1996 13 2 183 188
38. Effect of volume expansion with hypertonic- and isotonic saline and isotonic glucose on sodium and water transport in the principal cells in the kidney. Jensen JM, Mose FH, Bech JN, Nielsen S, Pedersen EB, BMC Nephrol 2013 14 1 202
39. Decrease in urinary excretion of aquaporin-2 associated with impaired urinary concentrating ability in diabetic nephropathy. Nakamura T, Saito T, Kusaka I, Higashiyama M, Nagasaka S, Ishibashi S, Ishikawa SE, Nephron 2002 92 2 445 448 (Pubitemid 35316893)
40. Medullary collecting duct function in the remnant kidney before and after volume expansion. Wilson DR, Sonnenberg H, Kidney Int 1979 15 5 487 501 (Pubitemid 9256744)
41. Regulation of plasma arginine vasopressin in patients with chronic renal failure maintained on hemodialysis. Jawadi MH, Ho LS, Dipette D, Ross DL, Am J Nephrol 1986 6 3 175 181 (Pubitemid 16022964)
42. Effect of water intake on the progression of chronic renal failure in the 5/6 nephrectomized rat. Bouby N, Bachmann S, Bichet D, Bankir L, Am J Physiol 1990 258 4 Pt 2 973 F979
43. Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat. Ecelbarger CA, Nielsen S, Olson BR, Murase T, Baker EA, Knepper MA, Verbalis JG, J Clin Invest 1997 99 8 1852 1863 (Pubitemid 27175932)
44. Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass. Kwon TH, Frokiaer J, Knepper MA, Nielsen S, Am J Physiol 1998 275 5 Pt 2 724 F741
45. Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. Teitelbaum I, McGuinness S, J Clin Invest 1995 96 1 378 385
46. Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Loffing J, Korbmacher C, Pflugers Arch 2009 458 1 111 135
47. Role of aldosterone in the remnant kidney model in the rat. Greene EL, Kren S, Hostetter TH, J Clin Invest 1996 98 4 1063 1068 (Pubitemid 26293326)
48. Role of aldosterone in the control of sodium excretion in patients with advanced chronic renal failure. Berl T, Katz FH, Henrich WL, de Torrente A, Schrier RW, Kidney Int 1978 14 3 228 235 (Pubitemid 9014989)
49. Plasma aldosterone concentrations in chronic renal disease. Hene RJ, Boer P, Koomans HA, Mees EJ, Kidney Int 1982 21 1 98 101 (Pubitemid 12135754)
50. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA, J Clin Invest 1999 104 7 19 R23
51. Body fluid volume determination via body composition spectroscopy in health and disease. Moissl UM, Wabel P, Chamney PW, Bosaeus I, Levin NW, Bosy-Westphal A, Korth O, Muller MJ, Ellegard L, Malmros V, Kaitwatcharachai C, Kuhlmann MK, Zhu F, Fuller NJ, Physiol Meas 2006 27 9 921 933 (Pubitemid 44131442)
52. Total body electrolyte composition and distribution of body water in uremia. Brennan BL, Yasumura S, Letteri JM, Cohn SH, Kidney Int 1980 17 3 364 371 (Pubitemid 10101595)
53. Utility of bioimpedance spectroscopy (BIS) in the management of refractory hypertension in patients with chronic kidney disease (CKD). Verdalles U, de Vinuesa SG, Goicoechea M, Quiroga B, Reque J, Panizo N, Arroyo D, Luno J, Nephrol Dial Transplant 2012 27 Suppl 4 v31 5