Degradation of teriparatide by gastro-intestinal proteolytic enzymes

Journal of Drug Targeting

Volumn 14, Issue 3, 2006, Pages 109-115

  Werle, Martin ^a   Samhaber, Annette ^b   Bernkop Schnürch, Andreas ^b  

^a Thiomatrix Forschungs und Beratungs GmbH   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Oral peptide delivery; Osteoporosis; Parathyroid hormone (1 34); PTH; Teriparatide

Indexed keywords

CELLACEFATE; CHYMOTRYPSIN; ELASTASE; ENZYME INHIBITOR; INTESTINE ENZYME; LIPOSOME; MICROSOMAL AMINOPEPTIDASE; NANOPARTICLE; PARATHYROID HORMONE[1-34]; PEPSIN A; POLYACRYLIC ACID; POLYMETHACRYLIC ACID; PROTEINASE; TRYPSIN;

ACCURACY; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG APPROVAL; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; ENTERIC COATED TABLET; ENZYME ISOLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TIME; NONHUMAN; OSSIFICATION; OSTEOPOROSIS; PERMEABILITY BARRIER; PRIORITY JOURNAL; RAT; SMALL INTESTINE MUCOSA; THIN LAYER CHROMATOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BONE DENSITY CONSERVATION AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; HYDROLYSIS; INTESTINE, SMALL; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; RATS; SEQUENCE HOMOLOGY, AMINO ACID; TERIPARATIDE;

EID: 33745081845     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860600647934     Document Type: Article

References (32)

1. Agu, RU and Valiveti, S and Earles, DC and Klausner, M and Hayden, PJ and Wermeling, DP and Stinchcomb, AL. (2004) Intranasal delivery of recombinant human parathyroid hormone [hPTH (1-34)], teriparatide in rats Endocr Res, 30(3), pp. 455-467.
2. Baumann, WK and Bizzozero, SA and Dutler, H. (1970) Specificity of alpha-chymotrypsin dipeptide substrates FEBS Lett, 8(5), pp. 257-260.
3. Berezin, IV and Martinek, K. (1970) Specificity of alpha-chymotrypsin FEBS Lett, 8(5), pp. 261-262.
4. Bernkop-Schnürch, A. (1998) The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins J Control Rel, 52 (1-2), pp. 1-16.
5. Bernkop-Schnürch, A and Fragner, R. (1996) Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration Pharm Sci, 2(1), pp. 361-363.
6. Bernkop-Schnürch, A and Paikl, C and Valenta, C. (1997) Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N Pharm Res, 14, pp. 917-922.
7. Bode, W. (1979) Activation, activity and inhibition of bovine trypsin Naturwissenschaften, 66(5), pp. 251-258.
8. Civitelli, R and Bacskai, BJ and Mahaut-Smith, MP and Adams, SR and Avioli, LV and Tsien, RY. (1994) Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells J Bone Miner Res, 9(9), pp. 1407-1417.
9. Dobnig, H and Turner, RT. (1997) The effects of programmed administration of human parathyroid hormone fragment (11-34) on bone histomorphometry and serum chemistry in rats Endocrinology, 138(11), pp. 4607-4612.
10. Fujii, S and Yokohama, T and Ikegaya, K and Salo, F and Yakoo, N. (1985) Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs J Pharm Pharmacol, 37, pp. 545-549.
11. Fujimori, A and Cheng, SL and Avioli, LV and Civitelli, R. (1992) Structure-function relationship of parathyroid hormone: Activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells Endocrinology, 130(1), pp. 29 - 36.
12. Guggi, D and Kast, CE and Bernkop-Schnürch, A. (2003) In vivo evaluation of an oral salmon calcitonin-delivery system based on a thiolated chitosan carrier matrix Pharm Res, 20(12), pp. 1989-1994.
13. Gupta, VK and Beckert, TE and Price, JC. (2001) A novel pH- and time-based multi-unit potential colonic drug delivery system. I. Development Int J Pharm, 213(1-2), pp. 83-91.
14. Ikesue, K and Kopeckova, P and Kopecek, J. (1993) Degradation of proteins by guinea pig intestinal enzymes Int J Pharm, 95, pp. 171-179.
15. Leone-Bay, A and Sato, M and Paton, D and Hunt, AH and Sarubbi, D and Carozza, M and Chou, J and McDonough, J and Baughman, RA. (2001) Oral delivery of biologically active parathyroid hormone Pharm Res, 18(7), pp. 964-970.
16. Lu, RH and Kopeckova, P and Kopecek, J. (1999) Degradation and aggregation of human calcitonin in vitro Pharm Res, 16(3), pp. 359-367.
17. Malm, CJJE and Hiatt, GD. (1951) Cellulose acetate phthalate as an enteric coating material J Am Pharm Assoc, 40(10), pp. 520-525.
18. Marschütz, MK and Caliceti, P and Bernkop-Schnürch, A. (2000) Design and in vivo evaluation of an oral delivery system for insulin Pharm Res, 17(12), pp. 1468-1474.
19. Mohan, S and Kutilek, S and Zhang, C and Shen, HG and Kodama, Y and Srivastava, AK and Wergedal, JE and Beamer, WG and Baylink, DJ. (2000) Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice Bone, 27(4), pp. 471-478.
20. Morishita, I and Morishita, M and Takayama, K and Machida, Y and Nagai, T. (1992) Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats Int J Pharm, 78, pp. 9-16.
21. Playford, RJ and Marchbank, T and Calnan, DP and Calam, J and Royston, P and Batten, JJ and Hansen, HF. (1995) Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice Gastroenterol, 108(1), pp. 92-101.
22. Potts, JT and Bringhurst, FR and Gardella, T and Nussbaum, S and Segre, G and Kronenberg, H. (1995) Parathyroid hormone: Physiology, chemistry, biosynthesis, secretion, metabolism, and mode of action 3rd ed. Philadelphia, P.A.: W.B. Saunders.
23. Sachdev, GP and Fruton, JS. (1970) Secondary enzyme-substrate interactions and the specificity of pepsin Biochemistry, 9(23), pp. 4465-4470.
24. Sato, M and Grese, TA and Dodge, JA and Bryant, HU and Turner, CH. (1999) Emerging therapies for the prevention or treatment of postmenopausal osteoporosis J Med Chem, 42(1), pp. 1-24.
25. Schilling, RJ and Mitra, AK. (1991) Degradation of insulin by trypsin and alpha-chymotrypsin Pharm Res, 8(6), pp. 721-727.
26. Tsomaia, N and Pellegrini, M and Hyde, K and Gardella, TJ and Mierke, DF. (2004) Toward parathyroid hormone minimization: Conformational studies of cyclic PTH(1-14) analogues Biochemistry, 43(3), pp. 690-699.
27. USP, C. (1990) United States Pharmacopeia XXII-NFXVII US Pharmacopeial Conv (40a), pp. 1788.
28. Valenta, C and Marschutz, M and Egyed, C and Bernkop-Schnürch, A. (2002) Evaluation of the inhibition effect of thiolated poly(acrylates) on vaginal membrane bound aminopeptidase N and release of the model drug LH-RH J Pharm Pharmacol, 54(5), pp. 603-610.
29. Wallace, RJ. (1992) Acetylation of peptides inhibits their degradation by rumen micro-organisms Br J Nutr, 68(2), pp. 365-372.
30. Woodley, JF. (1994) Enzymatic barriers for GI peptide and protein delivery Crit Rev Ther Drug Carrier, 11(2-3), pp. 61-95.
31. Yamamoto, A and Taniguchi, T and Rikyun, K and Tsuji, T and Fujita, T and Murakami, M and Muranishi, S. (1994) Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats Pharm Res, 11, pp. 1496-1500.
32. Yu, XP and Chandrasekhar, S. (1997) Parathyroid hormone (PTH 1-34) regulation of rat osteocalcin gene transcription Endocrinology, 138(8), pp. 3085-3092.