Beta 3-adrenoceptor activation just says NO to myocardial reperfusion injury

Journal of the American College of Cardiology

Volumn 58, Issue 25, 2011, Pages 2692-2694

  Heusch, Gerd ^a  

^a UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

Author keywords

beta 3 adrenergic receptor; cardiac ischemia; endothelial nitric oxide synthase; neuronal nitric oxide synthase; nitric oxide

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NEBIVOLOL; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; BENZOPYRAN DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ETHANOLAMINE DERIVATIVE;

BETA ADRENERGIC STIMULATION; DRUG MECHANISM; EDITORIAL; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE REPERFUSION; HUMAN; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; ENZYMOLOGY; MALE; METABOLISM; NOTE;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; BENZOPYRANS; ETHANOLAMINES; MALE; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; RECEPTORS, ADRENERGIC, BETA-3;

EID: 82955217763     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.09.034     Document Type: Editorial

References (24)

1. R.J. Burns, R.J. Gibbons, and Q. Yi The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis J Am Coll Cardiol 39 2002 30 36 (Pubitemid 34059858)
2. M. Ovize, G.F. Baxter, and F. Di Lisa Postconditioning and protection from reperfusion injury: where do we stand? Cardiovasc Res 87 2010 406 423
3. P.R. Maroko, P. Libby, and W.R. Ginks Coronary artery reperfusion I. Early effects on local myocardial function and the extent of myocardial necrosis J Clin Invest 51 1972 2710 2716
4. E. Braunwald Reduction of myocardial-infarct size N Engl J Med 291 1974 525 526
5. K.A. Reimer, R.B. Jennings, and F.R. Cobb Animal models for protecting ischemic myocardium: results of the NHLBI cooperative study Comparison of unconscious and conscious dog models Circ Res 56 1985 651 665 (Pubitemid 15093376)
6. E. Braunwald, and R.A. Kloner Myocardial reperfusion: a double-edged sword? J Clin Invest 76 1985 1713 1719 (Pubitemid 16196036)
7. G. Heusch Postconditioning Old wine in a new bottle? J Am Coll Cardiol 44 2004 1111 1112 (Pubitemid 39165148)
8. G. Heusch, K. Boengler, and R. Schulz Cardioprotection: nitric oxide, protein kinases, and mitochondria Circulation 118 2008 1915 1919
9. S.P. Jones, and R. Bolli The ubiquitous role of nitric oxide in cardioprotection J Mol Cell Cardiol 40 2006 16 23 (Pubitemid 43012113)
10. G. Heusch, H. Post, M.C. Michel, M. Kelm, and R. Schulz Endogenous nitric oxide and myocardial adaptation to ischemia Circ Res 87 2000 146 152 (Pubitemid 30616911)
11. C. Martin, R. Schulz, and H. Post Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia Cardiovasc Res 74 2007 46 55 (Pubitemid 46366945)
12. U.B. Hendgen-Cotta, M.W. Merx, and S. Shiva Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury Proc Natl Acad Sci U S A 105 2008 10256 10261
13. G. Heusch Nitroglycerin and delayed preconditioning in humans Yet another new mechanism for an old drug? Circulation 103 2001 2876 2878 (Pubitemid 32578120)
14. M.B. West, G. Rokosh, and D. Obal Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition Circulation 118 2008 1970 1978
15. G. Heusch Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents Br J Pharmacol 153 2008 1589 1601 (Pubitemid 351535988)
16. W. Vrydag, and M.C. Michel Tools to study beta(3)-adrenoceptors Naunyn Schmiedebergs Arch Pharmacol 374 2007 385 398
17. C. Dessy, J. Saliez, and P. Ghisdal Endothelial β3- adrenoceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation β-blocker nebivolol Circulation 112 2005 1198 1205 (Pubitemid 41216127)
18. A. Maffei, P.A. Di, and R. Carangi Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation Hypertension 50 2007 652 656 (Pubitemid 47442727)
19. J.P. Aragón, M.E. Condit, and S. Bhushan beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation J Am Coll Cardiol 58 2011 2683 2691
20. J.M. Downey, and M.V. Cohen We think we see a pattern emerging here Circulation 111 2005 120 121 (Pubitemid 40139719)
21. D.J. Hausenloy, G. Baxter, and R. Bell Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations Basic Res Cardiol 105 2010 677 686
22. L. Schwartz Longacre, R.A. Kloner, and A.E. Arai New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop Circulation 124 2011 1172 1179
23. A. Skyschally, P. van Caster, and K. Boengler Ischemic postconditioning in pigs: no causal role for RISK activation Circ Res 104 2009 15 18
24. K. Boengler, R. Schulz, and G. Heusch Loss of cardioprotection with ageing Cardiovasc Res 83 2009 247 261