메뉴 건너뛰기




Volumn 20, Issue 12, 2014, Pages 3118-3132

Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; WNT PROTEIN; CARRIER PROTEIN; CYSTEINE PROTEINASE; EXOSC4 PROTEIN, HUMAN; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; METHYLTRANSFERASE; MRNA (GUANINE(N7))-METHYLTRANSFERASE; NENF PROTEIN, HUMAN; NERVE PROTEIN; RASAL2 PROTEIN, HUMAN; RNA BINDING PROTEIN; SENP6 PROTEIN, HUMAN; SIGNAL PEPTIDE; TUMOR MARKER; WBSCR22 PROTEIN, HUMAN;

EID: 84902689867     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0283     Document Type: Article
Times cited : (88)

References (43)
  • 3
    • 25444491234 scopus 로고    scopus 로고
    • DNA methylation and demethylation as targets for anticancer therapy
    • DOI 10.1007/s10541-005-0147-7
    • Szyf M. DNA methylation and demethylation as targets for anticancer therapy. Biochemistry (Mosc) 2005;70:533-49. (Pubitemid 40920798)
    • (2005) Biochemistry (Moscow) , vol.70 , Issue.5 , pp. 533-549
    • Szyf, M.1
  • 4
    • 0035398558 scopus 로고    scopus 로고
    • Towards a pharmacology of DNA methylation
    • DOI 10.1016/S0165-6147(00)01713-2, PII S0165614700017132
    • Szyf M. Towards a pharmacology of DNA methylation. Trends Pharmacol Sci 2001;22:350-4. (Pubitemid 32592473)
    • (2001) Trends in Pharmacological Sciences , vol.22 , Issue.7 , pp. 350-354
    • Szyf, M.1
  • 5
    • 65249157050 scopus 로고    scopus 로고
    • Epigenetics, DNA methylation, and chromatin modifying drugs
    • Szyf M. Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 2009;49:243-63.
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 243-263
    • Szyf, M.1
  • 6
  • 7
    • 77958610661 scopus 로고    scopus 로고
    • An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer
    • Andersen JB, Factor VM, Marquardt JU, Raggi C, Lee YH, Seo D, et al. An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer. Sci Transl Med 2010;2:54ra77.
    • (2010) Sci Transl Med , vol.2
    • Andersen, J.B.1    Factor, V.M.2    Marquardt, J.U.3    Raggi, C.4    Lee, Y.H.5    Seo, D.6
  • 8
    • 0026534104 scopus 로고
    • Methylation patterns of long interspersed repeated DNA and alphoid repetitive DNA from human cell lines and tumors
    • Dante R, Dante-Paire J, Rigal D, Roizes G. Methylation patterns of long interspersed repeated DNA and alphoid repetitive DNA from human cell lines and tumors. Anticancer Res 1992;12:559-63.
    • (1992) Anticancer Res , vol.12 , pp. 559-563
    • Dante, R.1    Dante-Paire, J.2    Rigal, D.3    Roizes, G.4
  • 9
    • 84868687137 scopus 로고    scopus 로고
    • DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis
    • Mayol G, Martin-Subero JI, Rios J, Queiros A, Kulis M, Sunol M, et al. DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis. PLoS ONE 2012;7:e48401.
    • (2012) PLoS ONE , vol.7
    • Mayol, G.1    Martin-Subero, J.I.2    Rios, J.3    Queiros, A.4    Kulis, M.5    Sunol, M.6
  • 10
    • 27144437605 scopus 로고    scopus 로고
    • Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: Prognostic and therapeutic implications
    • DOI 10.2174/156800905774574011
    • Pakneshan P, Szyf M, Rabbani SA. Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: prognostic and therapeutic implications. Curr Cancer Drug Targets 2005;5:471-88. (Pubitemid 41502560)
    • (2005) Current Cancer Drug Targets , vol.5 , Issue.7 , pp. 471-488
    • Pakneshan, P.1    Szyf, M.2    Rabbani, S.A.3
  • 12
    • 1542636969 scopus 로고    scopus 로고
    • Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling
    • DOI 10.1038/sj.onc.1207269
    • Sato N, Fukushima N, Matsubayashi H, Goggins M. Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. Oncogene 2004;23:1531-8. (Pubitemid 38406515)
    • (2004) Oncogene , vol.23 , Issue.8 , pp. 1531-1538
    • Sato, N.1    Fukushima, N.2    Matsubayashi, H.3    Goggins, M.4
  • 13
    • 1842581856 scopus 로고    scopus 로고
    • Ras GTPase-activating Protein Binds to Akt and Is Required for Its Activation
    • DOI 10.1074/jbc.M312308200
    • Yue Y, Lypowy J, Hedhli N, Abdellatif M. Ras GTPase-activating protein binds to Akt and is required for its activation. J Biol Chem 2004;279:12883-9. (Pubitemid 38445863)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.13 , pp. 12883-12889
    • Yue, Y.1    Lypowy, J.2    Hedhli, N.3    Abdellatif, M.4
  • 14
    • 84864115184 scopus 로고    scopus 로고
    • ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells
    • Weeks A, Okolowsky N, Golbourn B, Ivanchuk S, Smith C, Rutka JT. ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells. Am J Pathol 2012;181:662-74.
    • (2012) Am J Pathol , vol.181 , pp. 662-674
    • Weeks, A.1    Okolowsky, N.2    Golbourn, B.3    Ivanchuk, S.4    Smith, C.5    Rutka, J.T.6
  • 15
    • 14044276944 scopus 로고    scopus 로고
    • Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity
    • DOI 10.1002/jnr.20356
    • Kimura I, Yoshioka M, Konishi M, Miyake A, Itoh N. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. J Neurosci Res 2005;79:287-94. (Pubitemid 40278342)
    • (2005) Journal of Neuroscience Research , vol.79 , Issue.3 , pp. 287-294
    • Kimura, I.1    Yoshioka, M.2    Konishi, M.3    Miyake, A.4    Itoh, N.5
  • 16
    • 84863100062 scopus 로고    scopus 로고
    • The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis
    • Han KH, Lee SH, Ha SA, Kim HK, Lee C, Kim DH, et al. The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis. BMC Cancer 2012;12:274.
    • (2012) BMC Cancer , vol.12 , pp. 274
    • Han, K.H.1    Lee, S.H.2    Ha, S.A.3    Kim, H.K.4    Lee, C.5    Kim, D.H.6
  • 17
    • 0035736207 scopus 로고    scopus 로고
    • Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome
    • Doll A, Grzeschik KH. Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome. Cytogenet Cell Genet 2001;95:20-7. (Pubitemid 34461821)
    • (2001) Cytogenetics and Cell Genetics , vol.95 , Issue.1-2 , pp. 20-27
    • Doll, A.1    Grzeschik, K.-H.2
  • 18
    • 79551553123 scopus 로고    scopus 로고
    • The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis
    • Nakazawa Y, Arai H, Fujita N. The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. Cancer Res 2011;71:1146-55.
    • (2011) Cancer Res , vol.71 , pp. 1146-1155
    • Nakazawa, Y.1    Arai, H.2    Fujita, N.3
  • 20
    • 79952846685 scopus 로고    scopus 로고
    • SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression
    • Bawa-Khalfe T, Yeh ET. SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression. Genes Cancer 2010;1:748-52.
    • (2010) Genes Cancer , vol.1 , pp. 748-752
    • Bawa-Khalfe, T.1    Yeh, E.T.2
  • 21
    • 38549136876 scopus 로고    scopus 로고
    • Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein
    • DOI 10.1128/MCB.01727-07
    • Li Y, Song MG, Kiledjian M. Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein. Mol Cell Biol 2008;28:939-48. (Pubitemid 351160050)
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.3 , pp. 939-948
    • Li, Y.1    Song, M.-G.2    Kiledjian, M.3
  • 22
    • 0017161004 scopus 로고
    • Modification of the 5′ terminus of mRNA by an RNA (guanine-7-)-methyltransferase from HeLa cells
    • Ensinger MJ, Moss B. Modification of the 5′ terminus of mRNA by an RNA (guanine-7-)-methyltransferase from HeLa cells. J Biol Chem 1976;251:5283-91.
    • (1976) J Biol Chem , vol.251 , pp. 5283-5291
    • Ensinger, M.J.1    Moss, B.2
  • 23
    • 76849084288 scopus 로고    scopus 로고
    • Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformation
    • Cowling VH. Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformation. Oncogene 2010;29:930-6.
    • (2010) Oncogene , vol.29 , pp. 930-936
    • Cowling, V.H.1
  • 25
    • 0033538072 scopus 로고    scopus 로고
    • DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen
    • Slack A, Cervoni N, Pinard M, Szyf M. DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. J Biol Chem 1999;274:10105-12.
    • (1999) J Biol Chem , vol.274 , pp. 10105-10112
    • Slack, A.1    Cervoni, N.2    Pinard, M.3    Szyf, M.4
  • 26
    • 0038678777 scopus 로고    scopus 로고
    • Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites
    • Colella S, Shen L, Baggerly KA, Issa JP, Krahe R. Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques 2003;35:146-50. (Pubitemid 36828724)
    • (2003) BioTechniques , vol.35 , Issue.1 , pp. 146-150
    • Colella, S.1    Shen, L.2    Baggerly, K.A.3    Issa, J.-P.J.4    Krahe, R.5
  • 27
    • 38449113853 scopus 로고    scopus 로고
    • DNA methylation analysis by pyrosequencing
    • DOI 10.1038/nprot.2007.314, PII NPROT.2007.314
    • Tost J, Gut IG. DNA methylation analysis by pyrosequencing. Nat Protoc 2007;2:2265-75. (Pubitemid 351575045)
    • (2007) Nature Protocols , vol.2 , Issue.9 , pp. 2265-2275
    • Tost, J.1    Gut, I.G.2
  • 28
    • 0040175067 scopus 로고    scopus 로고
    • Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
    • Frodin M, Gammeltoft S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol 1999;151:65-77.
    • (1999) Mol Cell Endocrinol , vol.151 , pp. 65-77
    • Frodin, M.1    Gammeltoft, S.2
  • 29
    • 84872392161 scopus 로고    scopus 로고
    • MAP kinase signalling cascades and transcriptional regulation
    • Yang SH, Sharrocks AD, Whitmarsh AJ. MAP kinase signalling cascades and transcriptional regulation. Gene 2013;513:1-13.
    • (2013) Gene , vol.513 , pp. 1-13
    • Yang, S.H.1    Sharrocks, A.D.2    Whitmarsh, A.J.3
  • 30
    • 0036193378 scopus 로고    scopus 로고
    • MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts
    • DOI 10.1128/MCB.22.8.2871-2881.2002
    • Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol 2002;22:2871-81. (Pubitemid 34263007)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.8 , pp. 2871-2881
    • Wiggin, G.R.1    Soloaga, A.2    Foster, J.M.3    Murray-Tait, V.4    Cohen, P.5    Arthur, J.S.C.6
  • 32
    • 0019318994 scopus 로고
    • DNA methylation and gene function
    • Razin A, Riggs AD. DNA methylation and gene function. Science 1980;210:604-10.
    • (1980) Science , vol.210 , pp. 604-610
    • Razin, A.1    Riggs, A.D.2
  • 34
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • DOI 10.1007/s12015-007-0004-8, PII SCR317
    • Dreesen O, Brivanlou AH. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev 2007;3:7-17. (Pubitemid 47472808)
    • (2007) Stem Cell Reviews , vol.3 , Issue.1 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 37
    • 0028964323 scopus 로고
    • Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis
    • MacLeod AR, Szyf M. Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. J Biol Chem 1995;270:8037-43.
    • (1995) J Biol Chem , vol.270 , pp. 8037-8043
    • MacLeod, A.R.1    Szyf, M.2
  • 40
    • 3843125363 scopus 로고    scopus 로고
    • Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis
    • DOI 10.1074/jbc.M401669200
    • Pakneshan P, Szyf M, Farias-Eisner R, Rabbani SA. Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis. J Biol Chem 2004;279:31735-44. (Pubitemid 39037845)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.30 , pp. 31735-31744
    • Pakneshan, P.1    Szyf, M.2    Farias-Eisner, R.3    Rabbani, S.A.4
  • 41
    • 33749483782 scopus 로고    scopus 로고
    • Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo
    • DOI 10.1158/0008-5472.CAN-06-1954
    • Shukeir N, Pakneshan P, Chen G, Szyf M, Rabbani SA. Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo. Cancer Res 2006;66:9202-10. (Pubitemid 44521141)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9202-9210
    • Shukeir, N.1    Pakneshan, P.2    Chen, G.3    Szyf, M.4    Rabbani, S.A.5
  • 42
    • 3843113658 scopus 로고    scopus 로고
    • Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo
    • DOI 10.1093/carcin/bgh045
    • Campbell PM, Bovenzi V, Szyf M. Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo. Carcinogenesis 2004;25:499-507. (Pubitemid 38499940)
    • (2004) Carcinogenesis , vol.25 , Issue.4 , pp. 499-507
    • Campbell, P.M.1    Bovenzi, V.2    Szyf, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.