Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 306, Issue 11, 2014, Pages

  Galinsky, Robert ^a   Jensen, Ellen C ^a   Bennet, Laura ^a   Mitchell, Clinton J ^a   Gunn, Eleanor R ^a   Wassink, Guido ^a   Fraser, Mhoyra ^a,b   Westgate, Jennifer A ^a   Gunn, Alistair J ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Fetal sheep; Repeated asphyxia; Sympathetic nervous system

Indexed keywords

OXIDOPAMINE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; ASPHYXIA; CONTROLLED STUDY; FEMORAL ARTERY FLOW; FETUS; FETUS HEART RATE; HYPERTENSION; HYPOTENSION; MEAN ARTERIAL PRESSURE; NONHUMAN; OCCLUSION; PRIORITY JOURNAL; SYMPATHECTOMY; UMBILICAL CORD; UMBILICAL CORD OBSTRUCTION;

FETAL SHEEP; REPEATED ASPHYXIA; SYMPATHETIC NERVOUS SYSTEM;

ANIMALS; ASPHYXIA; BLOOD PRESSURE; FEMALE; FETUS; HEART RATE; MODELS, ANIMAL; OXIDOPAMINE; PREGNANCY; REGIONAL BLOOD FLOW; SHEEP; SYMPATHECTOMY, CHEMICAL; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOLYTICS; UMBILICAL ARTERIES; UMBILICAL CORD; VASOCONSTRICTION;

EID: 84902687768     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00001.2014     Document Type: Article

References (53)

1. Adams MB, Simonetta G, McMillen IC. The non-neurogenic catecholamine response of the fetal adrenal to hypoxia is dependent on activation of voltage-sensitive Ca2 channels. Brain Res Dev Brain Res 94: 182-189, 1996.
2. Barcroft J. Researches in Prenatal Life. London and Oxford: Blackwell Scientific Publications, 1946.
3. Barlow RM. The foetal sheep: morphogenesis of the nervous system and histochemical aspects of myelination. J Comp Neurol 135: 249-262, 1969.
4. Bartelds B, van Bel F, Teitel DF, Rudolph AM. Carotid, not aortic, chemoreceptors mediate the fetal cardiovascular response to acute hypoxemia in lambs. Pediatr Res 34: 51-55, 1993.
5. Bennet L, Booth LC, Ahmed-Nasef N, Dean JM, Davidson J, Quaedackers JS, Gunn AJ. Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep. Am J Physiol Regul Integr Comp Physiol 293: R1280-R1286, 2007.
6. Bennet L, Roelfsema V, Dean J, Wassink G, Power GG, Jensen EC, Gunn AJ. Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep. Am J Physiol Regul Integr Comp Physiol 292: R1569-R1576, 2007.
7. Bennet L, Westgate JA, Lui YC, Wassink G, Gunn AJ. Fetal acidosis and hypotension during repeated umbilical cord occlusions are associated with enhanced chemoreflex responses in near-term fetal sheep. J Appl Physiol 99: 1477-1482, 2005.
8. Bishai JM, Blood AB, Hunter CJ, Longo LD, Power GG. Fetal lamb cerebral blood flow (CBF) and oxygen tensions during hypoxia: a comparison of laser Doppler and microsphere measurements of CBF. J Physiol 546: 869-878, 2003.
9. Booth LC, Gunn AJ, Malpas SJ, Barrett CJ, Davidson JO, Guild SJ, Bennet L. Baroreflex control of renal sympathetic nerve activity and heart rate in near-term fetal sheep. Exp Physiol 96: 736-744, 2011.
10. Booth LC, Malpas SC, Barrett CJ, Guild SJ, Gunn AJ, Bennet L. Renal sympathetic nerve activity during asphyxia in fetal sheep. Am J Physiol Regul Integr Comp Physiol 303: R30-R38, 2012.
11. Cheung CY. Direct adrenal medullary catecholamine response to hypoxia in fetal sheep. J Neurochem 52: 148-153, 1989.
12. Cheung CY. Fetal adrenal medulla catecholamine response to hypoxiadirect and neural components. Am J Physiol Regul Integr Comp Physiol 258: R1340-R1346, 1990.
13. Derks JB, Giussani DA, Jenkins SL, Wentworth RA, Visser GH, Padbury JF, Nathanielsz PW. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol 499: 217-226, 1997.
14. Drury PP, Booth LC, Bennet L, Davidson JO, Wibbens B, Gunn AJ. Dopamine infusion for post-resuscitation blood pressure support after profound asphyxia in near-term fetal sheep. Exp Physiol 98: 699-709, 2013.
15. Fletcher AJ, Gardner DS, Edwards CM, Fowden AL, Giussani DA. Development of the ovine fetal cardiovascular defense to hypoxemia towards full term. Am J Physiol Heart Circ Physiol 291: H3023-H3034, 2006.
16. Fletcher AJ, McGarrigle HH, Edwards CM, Fowden AL, Giussani DA. Effects of low dose dexamethasone treatment on basal cardiovascular and endocrine function in fetal sheep during late gestation. J Physiol 545: 649-660, 2002.
17. Forhead AJ, Fowden AL. Role of angiotensin II in the pressor response to cortisol in fetal sheep during late gestation. Exp Physiol 89: 323-329, 2004.
18. Giussani DA, Spencer JA, Moore PJ, Bennet L, Hanson MA. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol 461: 431-449, 1993.
19. Giussani DA, Unno N, Jenkins SL, Wentworth RA, Derks JB, Collins JH, Nathanielsz PW. Dynamics of cardiovascular responses to repeated partial umbilical cord compression in late-gestation sheep fetus. Am J Physiol Heart Circ Physiol 273: H2351-H2360, 1997.
20. Goldstein DS, Feuerstein G, Izzo JL Jr, Kopin IJ, Keiser HR. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man. Life Sci 28: 467-475, 1981.
21. Gonzalez H, Hunter CJ, Bennet L, Power GG, Gunn AJ. Cerebral oxygenation during post-asphyxial seizures in near-term fetal sheep. J Cereb Blood Flow Metab 25: 911-918, 2005.
22. Grant DA, Fauchere JC, Eede KJ, Tyberg JV, Walker AM. Left ventricular stroke volume in the fetal sheep is limited by extracardiac constraint and arterial pressure. J Physiol 535: 231-239, 2001.
23. Gratton R, Carmichael L, Homan J, Richardson B. Carotid arterial blood flow in the ovine fetus as a continuous measure of cerebral blood flow. J Soc Gynecol Investig 3: 60-65, 1996.
24. Green LR, Kawagoe Y, Homan J, White SE, Richardson BS. Adaptation of cardiovascular responses to repetitive umbilical cord occlusion in the late gestation ovine fetus. J Physiol 535: 879-888, 2001.
25. Iwamoto HS, Rudolph AM, Mirkin BL, Keil LC. Circulatory and humoral responses of sympathectomized fetal sheep to hypoxemia. Am J Physiol Heart Circ Physiol 245: H767-H772, 1983.
26. Jellyman JK, Gardner DS, Edwards CM, Fowden AL, Giussani DA. Fetal cardiovascular, metabolic and endocrine responses to acute hypoxaemia during and following maternal treatment with dexamethasone in sheep. J Physiol 567: 673-688, 2005.
27. Jensen A, Berger R. Fetal circulatory responses to oxygen lack. J Dev Physiol 16: 181-207, 1991.
28. Jensen A, Hanson MA. Circulatory responses to acute asphyxia in intact and chemodenervated fetal sheep near term. Reprod Fertil Dev 7: 1351-1359, 1995.
29. Jensen A, Lang U. Foetal circulatory responses to arrest of uterine blood flow in sheep: effects of chemical sympathectomy. J Dev Physiol 17: 75-86, 1992.
30. Jensen EC, Bennet L, Fraser M, Power GG, Hunter CJ, Gunn AJ. Adenosine A1 receptor mediated suppression of adrenal activity in nearterm fetal sheep. Am J Physiol Regul Integr Comp Physiol 298: R700-R706, 2010.
31. Jensen EC, Bennet L, Guild SJ, Booth LC, Stewart J, Gunn AJ. The role of the neural sympathetic and parasympathetic systems in diurnal and sleep state related cardiovascular rhythms in the late gestation ovine fetus. Am J Physiol Regul Integr Comp Physiol 297: R998-R1008, 2009.
32. Jones CT, Robinson RO. Plasma catecholamines in foetal and adult sheep. J Physiol 248: 15-33, 1975.
33. Jones CT, Roebuck MM, Walker DW, Johnston BM. The role of the adrenal medulla and peripheral sympathetic nerves in the physiological responses of the fetal sheep to hypoxia. J Dev Physiol 10: 17-36, 1988.
34. Lawler FH, Brace RA. Fetal and maternal arterial pressures and heart rates: histograms, correlations, and rhythms. Am J Physiol Regul Integr Comp Physiol 243: R433-R444, 1982.
35. Lewis AB, Sischo W. Cardiovascular and catecholamine responses to hypoxemia in chemically sympathectomized fetal lambs. Dev Pharmacol Ther 8: 129-140, 1985.
36. Lewis AB, Wolf WJ, Sischo W. Fetal cardiovascular and catecholamine responses to hypoxemia after chemical sympathectomy. Pediatr Res 18: 318-322, 1984.
37. McIntosh GH, Baghurst KI, Potter BJ, Hetzel BS. Foetal brain development in the sheep. Neuropathol Appl Neurobiol 5: 103-114, 1979.
38. Myers DA, Robertshaw D, Nathanielsz PW. Effect of bilateral splanchnic nerve section on adrenal function in the ovine fetus. Endocrinology 127: 2328-2335, 1990.
39. Padbury JF, Polk DH, Ervin MG, Berry LM, Ikegami M, Jobe AH. Postnatal cardiovascular and metabolic responses to a single intramuscular dose of betamethasone in fetal sheep born prematurely by cesarean section. Pediatr Res 38: 709-715, 1995.
40. Quaedackers JS, Roelfsema V, Hunter CJ, Heineman E, Gunn AJ, Bennet L. Polyuria and impaired renal blood flow after asphyxia in preterm fetal sheep. Am J Physiol Regul Integr Comp Physiol 286: R576-R583, 2004.
41. Roelfsema V, Gunn AJ, Fraser M, Quaedackers JS, Bennet L. Cortisol and ACTH responses to asphyxia in preterm fetal sheep. Exp Physiol 90: 545-555, 2005.
42. Rosnes JS, Valego N, Wang JJ, Perez FM, Rose JC. Renal mRNA response to reduced perfusion pressure conserved despite denervation in mature ovine fetuses. Am J Physiol Regul Integr Comp Physiol 280: R1830-R1836, 2001.
43. Schwab M, Roedel M, Anwar MA, Muller T, Schubert H, Buchwalder LF, Walter B, Nathanielsz PW. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol 528: 619-632, 2000.
44. Simmonds PJ, Phillips ID, Poore KR, Coghill ID, Young IR, Canny BJ. The role of the pituitary gland and ACTH in the regulation of mRNAs encoding proteins essential for adrenal steroidogenesis in the late-gestation ovine fetus. J Endocrinol 168: 475-485, 2001.
45. Tabsh K, Nuwayhid B, Murad S, Ushioda E, Erkkola R, Brinkman CR, 3rd, Assali NS. Circulatory effects of chemical sympathectomy in fetal, neonatal, and adult sheep. Am J Physiol Heart Circ Physiol 243: H113-H122, 1982.
46. Thompson RJ, Buttigieg J, Zhang M, Nurse CA. A rotenone-sensitive site and H2O2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells. Neuroscience 145: 130-141, 2007.
47. Wassink G, Bennet L, Booth LC, Jensen EC, Wibbens B, Dean JM, Gunn AJ. The ontogeny of hemodynamic responses to prolonged umbilical cord occlusion in fetal sheep. J Appl Physiol 103: 1311-1317, 2007.
48. Westgate J, Wassink G, Bennet L, Gunn AJ. Spontaneous hypoxia in multiple pregnancy is associated with early fetal decompensation and greater T wave elevation during brief repeated cord occlusion in near-term fetal sheep. Am J Obstet Gynecol 193: 1526-1533, 2005.
49. Westgate JA, Bennet L, Brabyn C, Williams CE, Gunn AJ. ST waveform changes during repeated umbilical cord occlusions in near-term fetal sheep. Am J Obstet Gynecol 184: 743-751, 2001.
50. Westgate JA, Bennet L, de Haan HH, Gunn AJ. Fetal heart rate overshoot during repeated umbilical cord occlusion in sheep. Obstet Gynecol 97: 454-459, 2001.
51. Westgate JA, Bennet L, Gunn AJ. Fetal heart rate variability changes during brief repeated umbilical cord occlusion in near term fetal sheep. Br J Obstet Gynaecol 106: 664-671, 1999.
52. Westgate JA, Gunn AJ, Bennet L, Gunning MI, de Haan HH, Gluckman PD. Do fetal electrocardiogram PR-RR changes reflect progressive asphyxia after repeated umbilical cord occlusion in fetal sheep? Pediatr Res 44: 297-303, 1998.
53. Westgate JA, Wibbens B, Bennet L, Wassink G, Parer JT, Gunn AJ. The intrapartum deceleration in center stage: a physiological approach to interpretation of fetal heart rate changes in labor. Am J Obstet Gynecol 197: e1-e11.236, 2007.