Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 36-44

  Fang, Yuxin ^a   Zhong, Wenjing ^a   Wang, Yue ^a   Xun, Tianrong ^a   Lin, Dongguo ^a   Liu, Wenjun ^a   Wang, Jingyu ^a   Lv, Lin ^a   Liu, Shuwen ^a   He, Jian ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Antimicrobial agents; Multiple modes of action; Short lipopeptides

Indexed keywords

AGAROSE; ANTIINFECTIVE AGENT; ARGININE; DNA; LIPOPEPTIDE; LYSINE; TRYPTOPHAN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CANDIDA ALBICANS; DNA BINDING; ERYTHROCYTE; ESCHERICHIA COLI; FLOW CYTOMETRY; HEMOLYSIS; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOPHORE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; DRUG DESIGN; DRUG EFFECTS; HELA CELL LINE; INTRACELLULAR SPACE; METABOLISM;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; CANDIDA ALBICANS; CELL MEMBRANE; DRUG DESIGN; ERYTHROCYTES; ESCHERICHIA COLI; HELA CELLS; HEMOLYSIS; HUMANS; INTRACELLULAR SPACE; LIPOPEPTIDES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902649528     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.003     Document Type: Article

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