Association analysis of the glucocorticoid receptor gene (NR3C1) haplotypes (ER22/23EK, N363S, BclI) with mood and anxiety disorders in patients with asthma

Experimental and Therapeutic Medicine

Volumn 8, Issue 2, 2014, Pages 662-670

  Panek, Michał ^a   Pietras, Tadeusz ^a   Szemraj, Janusz ^a   Kuna, Piotr ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Anxiety; Asthma; Breathlessness; Depression; Glucocorticoid receptor gene NR3C1; Inflammation

Indexed keywords

ALLERGEN;

ADULT; AGED; ANXIETY DISORDER; ARTICLE; ASTHMA; BECK DEPRESSION INVENTORY; CONTROLLED STUDY; DEPRESSION; DYSPNEA; FEMALE; GENDER; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GLUCOCORTICOID RECEPTOR GENE; HAPLOTYPE; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MOOD; NUCLEOTIDE SEQUENCE; OBESITY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SMOKING; SPIROMETRY; STATE TRAIT ANXIETY INVENTORY;

EID: 84902598420     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1734     Document Type: Article

References (48)

1. Kessler RC, McGonagle KA, Zhao S, et al: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 51: 8-19, 1994.
2. de Miguel Diez J, García RJ, Hernandez Barrera V, et al: Mental health among adults with asthma and chronic bronchitis. A population-based study in Spain. Respir Med 106: 924-932, 2012.
3. Wang ZL: Evolving role of systemic inflammation in comorbidities of chronic obstructive pulmonary disease. Chin Med J (Engl) 123: 3467-3478, 2010.
4. Pietras T, Panek M, Witusik A, et al: Analysis of the correlation between level of anxiety, intensity of depression and bronchial asthma control. Post Dermatol Alergol 28: 15-22, 2011.
5. Strelau J: Psychology of temperament. PWN, Warsaw, 2009 (In Polish).
6. Strelau J: Temperament, personality, activity. Academic Press, London, 1983.
7. Strelau J: The Psychology of individual differences. Scholar, Warsaw, 2006 (In Polish).
8. Sek H: Introduction to Clinical Psychology. Scholar, Warsaw, 2001 (In Polish).
9. Marques AH, Silverman MN and Sternberg EM: Glucocorticoid dysregulations and their clinical correlates. From receptors to therapeutics. Ann N Y Acad Sci 1179: 1-18, 2009.
10. Margaretten M, Julian L, Katz P and Yelin E.: Depression in patients with rheumatoid arthritis: description, causes and mechanisms. Int J Clin Rheumtol 6: 617-623, 2011.
11. Jacobson L: Hypothalamic-pituitary-adrenocortical axis regulation. Endocrinol Metab Clin North Am 34: 271-292, 2005.
12. Elomaa AP, Niskanen L, Herzig KH, et al: Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder. BMC Psychiatry 12: 2, 2012.
13. Favreau H, Bacon SL, Joseph M, et al: Association between asthma medications and suicidal ideation in adult asthmatics. Respir Med 106: 933-941, 2012.
14. Pace TW, Hu F and Miller AH: Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav Immun 21: 9-19, 2007.
15. Irwin MR and Miller AH: Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav Immun 21: 374-383, 2007.
16. Khairova RA, Machado-Vieira R, Du J and Manji HK: A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol 12: 561-578, 2009.
17. Denayer E, Ahmed T, Brems H, et al: Spred1 is required for synaptic plasticity and hippocampus-dependent learning. J Neurosci 28: 14443-14449, 2008.
18. Heim MH: The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus. Eur J Clin Invest 26: 1-12, 1996.
19. Zambrano A, Otth C, Maccioni RB and Concha II: IL-3 controls tau modifications and protects cortical neurons from neurodegeneration. Curr Alzheimer Res 7: 615-624, 2010.
20. Hu F, Pace TW and Miller AH: Interferon-alpha inhibits glucocorticoid receptor-mediated gene transcription via STAT5 activation in mouse HT22 cells. Brain Behav Immun 23: 455-463, 2009.
21. Owens MJ and Nemeroff CB: Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 43: 425-473, 1991.
22. Raison CL and Miller AH: When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry 160: 1554-1565, 2003.
23. Raison CL, Capuron L and Miller AH: Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27: 24-31, 2006.
24. Pariante CM and Miller AH: Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49: 391-404, 2001.
25. Panek M, Pietras T, Antczak A, et al: The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1 gene in patients with bronchial asthma. Int J Mol Med 30: 142-150, 2012.
26. Panek M, Pietras T, Antczak A, et al: The role of functional single nucleotide polymorphisms of the human glucocorticoid receptor gene NR3C1 in Polish patients with bronchial asthma. Mol Biol Rep 39: 4749-4757, 2012.
27. Stevens A, Ray DW, Zeggini E, et al: Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab 89: 892-897, 2004.
28. Nicolaides NC, Galata Z, Kino T, et al: The human glucocorticoid receptor: molecular basis of biologic function. Steroids 75: 1-12, 2010.
29. Bray PJ and Cotton RG: Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms. Hum Mutat 21: 557-568, 2003.
30. DeRijk RH, Schaaf M and de Kloet ER: Glucocorticoid receptor variants: clinical implications. J Steroid Biochem Mol Biol 81: 103-122, 2002.
31. Ito K, Chung KF and Adcock IM: Update on glucocorticoid action and resistance. J Allergy Clin Immunol 117: 522-543, 2006.
32. van Rossum EF, Voorhoeve PG, te Velde SJ, et al: The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. J Clin Endocrinol Metab 89: 4004-4009, 2004.
33. Bulas M, Trelińska J, Stolarska M, et al: Association of steroid receptor gene (NR3C1) polymorphism with clinical course of lymphoproliferative disorders in children - preliminary results. Onkol Pol 2: 77-81, 2008.
34. Miller M, Hankinson J, Brusasco V, et al; ATS/ERS Task Force: Standardisation of spirometry. Eur Respir J 26: 319-338, 2005.
35. Beck AT, Ward CH, Mendelson M, et al: An inventory for measuring depression. Arch Gen Psychiatry 4: 561-571, 1961.
36. Puzyński S and Wciórka J: The tools of mental state assessment. In: Bilikiewicz A Pużyński S, Rybakowski J, editors. Psychiatry. Medical Publisher Urban & Partner, Wrocław, pp453-538, 2002 (In Polish).
37. Pietras T, Panek M, Witusik A, et al: Analysis of the correlation between anxiety, depression, intensity of dyspnoea and severity of the bronchial asthma disease process. Post Dermatol Alergol 27: 390-399, 2010.
38. Wrześniewski K, Sosnowski T and Matusik D: Inventory of State and Trait Anxiety STAI. Polish adaptation of STAI. Handbook. Laboratory of Psychological Tests of The Polish Psychological Association, Warsaw, 2002 (In Polish).
39. Grammatopoulou E, Skordilis E, Koutsouki D and Baltopoulos G: An 18-item standardized asthma quality of life questionnaire-AQLQ(S). Qual Life Res 17: 323-332, 2008.
40. Szabó V, Borgulya G, Filkorn T, et al: The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy. Mol Vis 13: 659-666, 2007.
41. Majnik J, Patócs A, Balogh K, et al: A rapid and simple method for detection of Asn363Ser polymorphism of the human glucocorticoid receptor gene. J Steroid Biochem Mol Biol 92: 465-468, 2004.
42. Kino T, De Martino MU, Charmandari E, et al: Tissue glucocorticoid resistance/hypersensitivity syndromes. J Steroid Biochem Mol Biol 85: 457-467, 2003.
43. van Rossum EF and Lamberts SW: Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res 59: 333-357, 2004.
44. de Lange P, Koper JW, Huizenga NA, et al: Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants. Mol Endocrinol 11: 1156-1164, 1997.
45. Grzanka A and Rogala B: Molecular mechanism of glucocorticoids and difficult asthma. Allerg Asthma Immunol 5: 247-252, 2000.
46. Derijk R and de Kloet E: Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience. Eur J Pharmacol 583: 303-311, 2008.
47. Pietras T, Panek M, Tworek D, et al: The BclI single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study. Mol Biol Rep 38: 3953-3958, 2011.
48. Panek M, Pietras T, Fabijan A, et al: Effect of glucocorticoid receptor gene polymorphisms on asthma phenotypes. Exp Ther Med 5: 572-580, 2013