The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements

Nutrients

Volumn 6, Issue 6, 2014, Pages 2290-2304

  Roke, Kaitlin ^a   Mutch, David M ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Docosahexaenoic acid (DHA); Eicosapentaenoic acid (EPA); Fatty acid desaturase 1 and 2 (FADS1 2); Glucose; Omega 3 (n 3) fatty acids; Red blood cells (RBC); Serum; Single nucleotide polymorphisms (SNPs); Triglycerides (TAG)

Indexed keywords

ACYL COENZYME A DESATURASE 1; ARACHIDONIC ACID; C REACTIVE PROTEIN; CHOLESTEROL; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; FATTY ACID DESATURASE 2; FISH OIL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; INSULIN; LINOLENIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEPTIDES AND PROTEINS; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ACYL COENZYME A DESATURASE; BIOLOGICAL MARKER; DELTA-5 FATTY ACID DESATURASE; FADS2 PROTEIN, HUMAN; FATTY ACID;

ADULT; ALLELE; ARTICLE; BLOOD SAMPLING; DIET SUPPLEMENTATION; ERYTHROCYTE; FATTY ACID ANALYSIS; GAS CHROMATOGRAPHY; GENE CLUSTER; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; MALE; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT; ADOLESCENT; BLOOD; DIETARY SUPPLEMENT; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; METABOLISM;

ADOLESCENT; ADULT; BIOMARKERS; DIETARY SUPPLEMENTS; FATTY ACID DESATURASES; FATTY ACIDS; FISH OILS; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; YOUNG ADULT;

EID: 84902585337     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6062290     Document Type: Article

References (48)

1. Cordain, L.; Eaton, S.B.; Sebastian, A.; Mann, N.; Lindeberg, S.; Watkins, B.A.; O'Keefe, J.H.; Brand-Miller, J. Origins and evolution of the western diet: Health implications for the 21st century. Am. J. Clin. Nutr. 2005, 81, 341-354.
2. Cleland, L.G.; James, M.J.; Proudman, S.M. Fish oil: What the prescriber needs to know. Arthritis Res. Ther. 2006, 8, 202.
3. Kris-Etherton, P.M.; Harris, W.S.; Appel, L.J. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 2003, 23, e20-e30.
4. Tur, J.; Bibiloni, M.; Sureda, A.; Pons, A. Dietary sources of omega 3 fatty acids: Public health risks and benefits. Br. J. Nutr. 2012, 107, S23-S52.
5. Torrejon, C.; Jung, U.; Deckelbaum, R. n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms. Prostaglandins Leukot. Essent. Fatty Acids 2007, 77, 319-326.
6. Kromhout, D.; de Goede, J. Update on cardiometabolic health effects of ω-3 fatty acids. Curr. Opin. Lipidol. 2014, 25, 85-90.
7. Lorente-Cebrián, S.; Costa, A.G.; Navas-Carretero, S.; Zabala, M.; Martínez, J.A.; Moreno-Aliaga, M.J. Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: A review of the evidence. J. Physiol. Biochem. 2013, 69, 633-651.
8. Balk, E.M.; Lichtenstein, A.H.; Chung, M.; Kupelnick, B.; Chew, P.; Lau, J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review. Atherosclerosis 2006, 189, 19-30.
9. Eslick, G.D.; Howe, P.R.; Smith, C.; Priest, R.; Bensoussan, A. Benefits of fish oil supplementation in hyperlipidemia: A systematic review and meta-analysis. Int. J. Cardiol. 2009, 136, 4-16.
10. Hartweg, J.; Perera, R.; Montori, V.; Dinneen, S.; Neil, H.; Farmer, A. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus. Cochrane Database Syst. Rev. 2008, 1, doi:10.1002/14651858.CD003205.pub2.
11. Karaouzene, N.; Merzouk, H.; Aribi, M.; Merzouk, S.; Yahia Berrouiguet, A.; Tessier, C.; Narce, M. Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: A comparison of older with young men. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 792-799.
12. Janssen, I. Influence of age on the relation between waist circumference and cardiometabolic risk markers. Nutr. Metab. Cardiovasc. Dis. 2009, 19, 163-169.
13. Kitson, A.P.; Stroud, C.K.; Stark, K.D. Elevated production of docosahexaenoic acid in females: Potential molecular mechanisms. Lipids 2010, 45, 209-224.
14. Hodson, L.; Skeaff, C.M.; Fielding, B.A. Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog. Lipid Res. 2008, 47, 348-380.
15. Metherel, A.; Armstrong, J.; Patterson, A.; Stark, K. Assessment of blood measures of n-3 polyunsaturated fatty acids with acute fish oil supplementation and washout in men and women. Prostaglandins Leukot. Essent. Fatty Acids 2009, 81, 23-29.
16. Marangoni, F.; Angeli, M.T.; Colli, S.; Eligini, S.; Tremoli, E.; Sirtori, C.R.; Galli, C. Changes of n-3 and n-6 fatty acids in plasma and circulating cells of normal subjects, after prolonged administration of 20:5 (EPA) and 22:6 (DHA) ethyl esters and prolonged washout. Biochem. Biophys. Acta 1993, 1210, 55-62.
17. Katan, M.; Deslypere, J.; van Birgelen, A.; Penders, M.; Zegwaard, M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: An 18-month controlled study. J. Lipid Res. 1997, 38, 2012-2022.
18. Cao, J.; Schwichtenberg, K.A.; Hanson, N.Q.; Tsai, M.Y. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin. Chem. 2006, 52, 2265-2272.
19. Merino, D.M.; Ma, D.; Mutch, D.M. Genetic variation in lipid desaturases and its impact on the development of human disease. Lipids Health Dis. 2010, 9, doi:10.1186/1476-511X-9-63.
20. Kwak, J.H.; Paik, J.K.; Kim, O.Y.; Jang, Y.; Lee, S.-H.; Ordovas, J.M.; Lee, J.H. FADS gene polymorphisms in Koreans: Association with ω-6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. Atherosclerosis 2011, 214, 94-100.
21. Kröger, J.; Schulze, M.B. Recent insights into the relation of δ5 desaturase and δ6 desaturase activity to the development of type 2 diabetes. Curr. Opin. Lipidol. 2012, 23, 4-10.
22. Simopoulos, A.P. Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: Their role in the determination of nutritional requirements and chronic disease risk. Exp. Biol. Med. 2010, 235, 785-795.
23. Lattka, E.; Illig, T.; Heinrich, J.; Koletzko, B. Do fads genotypes enhance our knowledge about fatty acid related phenotypes? Clin. Nutr. 2010, 29, 277-287.
24. Roke, K.; Ralston, J.C.; Abdelmagid, S.; Nielsen, D.E.; Badawi, A.; El-Sohemy, A.; Ma, D.W.; Mutch, D.M. Variation in the fads1/2 gene cluster alters plasma n-6 pufa and is weakly associated with hscrp levels in healthy young adults. Prostaglandins Leukot. Essent. Fatty Acids 2013, 89, 257-263.
25. Martinelli, N.; Girelli, D.; Malerba, G.; Guarini, P.; Illig, T.; Trabetti, E.; Sandri, M.; Friso, S.; Pizzolo, F.; Schaeffer, L. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am. J. Clin. Nutr. 2008, 88, 941-949.
26. Cormier, H.; Rudkowska, I.; Paradis, A.-M.; Thifault, E.; Garneau, V.; Lemieux, S.; Couture, P.; Vohl, M.-C. Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation. Nutrients 2012, 4, 1026-1041.
27. Gillingham, L.G.; Harding, S.V.; Rideout, T.C.; Yurkova, N.; Cunnane, S.C.; Eck, P.K.; Jones, P.J. Dietary oils and FADS1-FADS2 genetic variants modulate [13c] α-linolenic acid metabolism and plasma fatty acid composition. Am. J. Clin. Nutr. 2013, 97, 195-207.
28. Al-Hilal, M.; AlSaleh, A.; Maniou, Z.; Lewis, F.J.; Hall, W.L.; Sanders, T.A.; O'Dell, S.D. Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. J. Lipid Res. 2013, 54, 542-551.
29. Lawson, L.D.; Hughes, B.G. Absorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacylglycerols or fish oil ethyl esters co-ingested with a high-fat meal. Biochem. Biophys. Res. Commun. 1988, 156, 960-963.
30. Merino, D.M.; Johnston, H.; Clarke, S.; Roke, K.; Nielsen, D.; Badawi, A.; El-Sohemy, A.; Ma, D.W.; Mutch, D.M. Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults. Mol. Genet. Metab. 2011, 103, 171-178.
31. dbSNP Short Genetic Variations. Available online: http://www.ncbi.nlm.nih.gov/SNP/ (accessed on 8 April 2014).
32. Lattka, E.; Illig, T.; Koletzko, B.; Heinrich, J. Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism. Curr. Opin. Lipidol. 2010, 21, 64-69.
33. Tanaka, T.; Shen, J.; Abecasis, G.R.; Kisialiou, A.; Ordovas, J.M.; Guralnik, J.M.; Singleton, A.; Bandinelli, S.; Cherubini, A.; Arnett, D. Genome-wide association study of plasma polyunsaturated fatty acids in the inchianti study. PLoS Genet. 2009, 5, e1000338.
34. SNAP SNP Annotation and Proxy Search. Available online: http://www.broadinstitute.org/mpg/snap (accessed on 14 October 2013).
35. Pettersson, F.H.; Anderson, C.A.; Clarke, G.M.; Barrett, J.C.; Cardon, L.R.; Morris, A.P.; Zondervan, K.T. Marker selection for genetic case-control association studies. Nat. Protoc. 2009, 4, 743-752.
36. Holub, B.; Mutch, D.M.; Pierce, G.N.; Rodriguez-Leyva, D.; Aliani, M.; Innis, S.; Yan, W.; Lamarche, B.; Couture, P.; Ma, D.W. Proceedings from the 2013 canadian nutrition society conference on advances in dietary fats and nutrition. Appl. Physiol. Nutr. Metab. 2014, in press.
37. Leiter, L.A.; Fitchett, D.H.; Gilbert, R.E.; Gupta, M.; Mancini, G.; McFarlane, P.A.; Ross, R.; Teoh, H.; Verma, S.; Anand, S. Cardiometabolic risk in canada: A detailed analysis and position paper by the cardiometabolic risk working group. Can. J. Cardiol. 2011, 27, e1-e33.
38. Pereira, M.A.; Jacobs, D.R.; Pins, J.J.; Raatz, S.K.; Gross, M.D.; Slavin, J.L.; Seaquist, E.R. Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am. J. Clin. Nutr. 2002, 75, 848-855.
39. Harris, W.S.; Pottala, J.V.; Sands, S.A.; Jones, P.G. Comparison of the effects of fish and fish-oil capsules on the n-3 fatty acid content of blood cells and plasma phospholipids. Am. J. Clin. Nutr. 2007, 86, 1621-1625.
40. Von Schacky, C.; Fischer, S.; Weber, P.C. Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. J. Clin. Investig. 1985, 76, 1626.
41. Adkins, Y.; Kelley, D.S. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J. Nutr. Biochem. 2010, 21, 781-792.
42. Pinel, A.; Morio-Liondore, B.; Capel, F. n-3 Polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: Implication for the prevention of type 2 diabetes. J. Physiol. Biochem. 2013, 70, 1-12.
43. Zulyniak, M.A.; Perreault, M.; Gerling, C.; Spriet, L.L.; Mutch, D.M. Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. Metabolism 2013, 62, 1107-1113.
44. Fekete, K.; Marosvölgyi, T.; Jakobik, V.; Decsi, T. Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: A systematic review. Am. J. Clin. Nutr. 2009, 89, 2070S-2084S.
45. Barceló-Coblijn, G.; Murphy, E.J.; Othman, R.; Moghadasian, M.H.; Kashour, T.; Friel, J.K. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: A multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am. J. Clin. Nutr. 2008, 88, 801-809.
46. Global Lipids Genetics Consortium; Willer, C.J.; Schmidt, E.M.; Sengupta, S.; Peloso, G.M.; Gustafsson, S.; Kanoni, S.; Ganna, A.; Chen, J.; Buchkovich, M.L. et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 2013, 45, 1274-1283.
47. Schaeffer, L.; Gohlke, H.; Müller, M.; Heid, I.M.; Palmer, L.J.; Kompauer, I.; Demmelmair, H.; Illig, T.; Koletzko, B.; Heinrich, J. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum. Mol. Genet. 2006, 15, 1745-1756.
48. Keenan, A.H.; Pedersen, T.L.; Fillaus, K.; Larson, M.K.; Shearer, G.C.; Newman, J.W. Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-hufa in healthy volunteers. J. Lipid Res. 2012, 53, 1662-1669.