Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 14, 2014, Pages 2985-2990

  Singh, Kawaljit ^a   Kumar, Malkeet ^a   Pavadai, Elumalai ^a   Naran, Krupa ^a   Warner, Digby F ^a   Ruminski, Peter G ^b   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Efflux pump; Rifampicin; Rv1258c; Tuberculosis; Verapamil

Indexed keywords

RIFAMPICIN; VERAPAMIL DERIVATIVE; ABC TRANSPORTER; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; RV1258C PROTEIN, MYCOBACTERIUM TUBERCULOSIS; VERAPAMIL;

ARTICLE; BINDING SITE; DRUG INHIBITION; DRUG STRUCTURE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

MYCOBACTERIUM TUBERCULOSIS;

ANTI-BACTERIAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; RIFAMPIN; STRUCTURE-ACTIVITY RELATIONSHIP; VERAPAMIL;

EID: 84902553776     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.022     Document Type: Article

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