A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile

International Journal of Antimicrobial Agents

Volumn 44, Issue 1, 2014, Pages 69-73

  Katzianer, David S ^a   Yano, Takahiro ^b   Rubin, Harvey ^b   Zhu, Jun ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antibiotic discovery; Clostridium difficile; High throughput screen; Small molecule library

Indexed keywords

5 NITRO 1,10 PHENANTHROLINE; ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; 5-NITRO-1,10-PHENANTHROLINE; IRON; MOLECULAR LIBRARY; PHENANTHROLINE DERIVATIVE; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BIOFILM; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DISEASE COURSE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SPECIFICITY; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IRON CHELATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; DRUG EFFECTS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR LIBRARY; MYCOBACTERIUM BOVIS; PEPTOCLOSTRIDIUM DIFFICILE; PHARMACOLOGY; SPECIES DIFFERENCE;

ANIMALS; ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HIGH-THROUGHPUT SCREENING ASSAYS; IRON; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM BOVIS; PHENANTHROLINES; SMALL MOLECULE LIBRARIES; SPECIES SPECIFICITY; VANCOMYCIN;

EID: 84902550188     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2014.03.007     Document Type: Article

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