Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance

Hippocampus

Volumn 24, Issue 7, 2014, Pages 840-852

  Carrasco, Manuel ^a   Rabaneda, Luis G ^a   Murillo Carretero, Maribel ^a   Ortega Martínez, Sylvia ^a   Martínez Chantar, María L ^b   Woodhoo, Ashwin ^b   Luka, Zigmund ^c   Wagner, Conrad ^c   Lu, Shelly C ^d   Mato, José M ^b   Micó, Juan A ^a   Castro, Carmen ^a  

^a UNIVERSITY OF CÁDIZ   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Glycine N methyltransferase; Learning; Memory; Neural progenitor cells; Neurogenesis; S adenosylmethionine

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; CYCLIN E; GLYCINE METHYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; FIBROBLAST GROWTH FACTOR 2; GNMT PROTEIN, MOUSE; MAT1A PROTEIN, MOUSE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; NERVE PROTEIN; S ADENOSYLMETHIONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL PROLIFERATION; CELL STIMULATION; COGNITION; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVITY; HIPPOCAMPUS; IN VITRO STUDY; MALE; MEMORY DISORDER; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPATIAL LEARNING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DEFICIENCY; DISORDERS OF AMINO ACID AND PROTEIN METABOLISM; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; MAZE TEST; MEMORY DISORDERS; METABOLISM; METHYLATION; NERVE CELL PLASTICITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; ROTAROD TEST;

AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; COGNITION; CYCLIN E; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; GLYCINE N-METHYLTRANSFERASE; HIPPOCAMPUS; MAP KINASE SIGNALING SYSTEM; MAZE LEARNING; MEMORY DISORDERS; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; METHYLATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONAL PLASTICITY; ROTAROD PERFORMANCE TEST; S-ADENOSYLMETHIONINE;

EID: 84902550118     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.22274     Document Type: Article

References (50)

1. Augoustides-Savvopoulou P, Luka Z, Karyda S, Stabler SP, Allen RH, Patsiaoura K, Wagner C, Mudd SH. 2003. Glycine N-methyltransferase deficiency: A new patient with a novel mutation. J Inherit Metab Dis 26:745-759.
2. Bull ND, Bartlett PF. 2005. The adult mouse hippocampal progenitor is neurogenic but not a stem cell. J Neurosci 25:10815-10821.
3. Cai J, Mao Z, Hwang JJ, Lu SC. 1998. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer Res 58:1444-1450.
4. Cameron HA, McKay RD. 2001. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 435:406-417.
5. Cantoni GL. 1975. Biological methylation: Selected aspects. Annu Rev Biochem 44:435-451.
6. Clarke S, Banfield K. 2001. S-adenosylmethionine dependent methyltransferase. In: Homocysteine in Health and Disease, Carmel R, Jacobsen DW, editors. Cambridge: Cambridge University Press. pp 63-78.
7. Coppede F. 2010. One-carbon metabolism and Alzheimer's disease: Focus on epigenetics. Curr Genomics 11:246-260.
8. Covic M, Karaca E, Lie DC. 2010. Epigenetic regulation of neurogenesis in the adult hippocampus. Heredity (Edinb) 105:122-134.
9. Doetsch F, Petreanu L, Caille I, Garcia-Verdugo JM, Alvarez-Buylla A. 2002. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 36:1021-1034.
10. Feng J, Chang H, Li E, Fan G. 2005. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res 79:734-746.
11. Finkelstein JD, Kyle WE, Harris BJ. 1974. Methionine metabolism in mammals: Regulatory effects of S-adenosylhomocysteine. Arch Biochem Biophys 165:774-779.
12. Fuso A, Nicolia V, Ricceri L, Cavallaro RA, Isopi E, Mangia F, Fiorenza MT, Scarpa S. 2012. S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice. Neurobiol Aging 33:1482 e1-16.
13. Kerr SJ. 1972. Competing methyltransferase systems. J Biol Chem 247:4248-4252.
14. Levenson JM, Sweatt JD. 2005. Epigenetic mechanisms in memory formation. Nat Rev Neurosci 6:108-118.
15. Levenson JM, Sweatt JD. 2006. Epigenetic mechanisms: A common theme in vertebrate and invertebrate memory formation. Cell Mol Life Sci 63:1009-1016.
16. Levine J, Stahl Z, Sela BA, Gavendo S, Ruderman V, Belmaker RH. 2002. Elevated homocysteine levels in young male patients with schizophrenia. Am J Psychiatry 159:1790-1792.
17. Lu SC, Mato JM. 2012. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev 92:1515-1542.
18. Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, Avila MA, Kanel G, Mato JM. 2001. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 98:5560-5565.
19. Luka Z, Cerone R, Phillips JA III, Mudd HS, Wagner C. 2002. Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum Genet 110:68-74.
20. Luka Z, Capdevila A, Mato JM, Wagner C. 2006. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res 15:393-397.
21. Luka Z, Mudd SH, Wagner C. 2009. Glycine N-methyltransferase and regulation of S-adenosylmethionine levels. J Biol Chem 284:22507-22511.
22. Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. 2009. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323:1074-1077.
23. Martinez-Chantar ML, Vazquez-Chantada M, Garnacho M, Latasa MU, Varela-Rey M, Dotor J, Santamaria M, Martinez-Cruz LA, Parada LA, Lu SC, et al. 2006. S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Gastroenterology 131:223-232.
24. Martinez-Chantar ML, Vazquez-Chantada M, Ariz U, Martinez N, Varela M, Luka Z, Capdevila A, Rodriguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM. 2008. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology 47:1191-1199.
25. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. 2011. Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging 32:1161-1180.
26. Miller JW. 1999. Homocysteine and Alzheimer's disease. Nutr Rev 57:126-129.
27. Miller JW. 2002. Homocysteine, folate deficiency, and Parkinson's disease. Nutr Rev 60:410-413.
28. Miller CA, Sweatt JD. 2007. Covalent modification of DNA regulates memory formation. Neuron 53:857-869.
29. Miller JW, Green R, Ramos MI, Allen LH, Mungas DM, Jagust WJ, Haan MN. 2003. Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging. Am J Clin Nutr 78:441-447.
30. Mudd SH, Cerone R, Schiaffino MC, Fantasia AR, Minniti G, Caruso U, Lorini R, Watkins D, Matiaszuk N, Rosenblatt DS, et al. 2001. Glycine N-methyltransferase deficiency: A novel inborn error causing persistent isolated hypermethioninaemia. J Inherit Metab Dis 24:448-464.
31. Quadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M, Lucca U. 2004. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 80:114-122.
32. Rabaneda LG, Carrasco M, Lopez-Toledano MA, Murillo-Carretero M, Ruiz FA, Estrada C, Castro C. 2008. Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB J 22:3823-3835.
33. Romero-Grimaldi C, Gheusi G, Lledo PM, Estrada C. 2006. Chronic inhibition of nitric oxide synthesis enhances both subventricular zone neurogenesis and olfactory learning in adult mice. Eur J Neurosci 24:2461-2470.
34. Roth TL, Sweatt JD. 2009. Regulation of chromatin structure in memory formation. Curr Opin Neurobiol 19:336-342.
35. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. 2002. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346:476-483.
36. Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E. 2001. Neurogenesis in the adult is involved in the formation of trace memories. Nature 410:372-376.
37. Shors TJ, Townsend DA, Zhao M, Kozorovitskiy Y, Gould E. 2002. Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 12:578-584.
38. Sierra A, Encinas JM, Deudero JJ, Chancey JH, Enikolopov G, Overstreet-Wadiche LS, Tsirka SE, Maletic-Savatic M. 2010. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 7:483-495.
39. Silverstein AM, Barrow CA, Davis AJ, Mumby MC. 2002. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Proc Natl Acad Sci USA 99:4221-4226.
40. Snyder JS, Hong NS, McDonald RJ, Wojtowicz JM. 2005. A role for adult neurogenesis in spatial long-term memory. Neuroscience 130:843-852.
41. Struys EA, Jansen EE, de Meer K, Jakobs C. 2000. Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem 46:1650-1656.
42. Torroglosa A, Murillo-Carretero M, Romero-Grimaldi C, Matarredona ER, Campos-Caro A, Estrada C. 2007. Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway. Stem Cells 25:88-97.
43. Tropepe V. 2007. Kinship and descent: Redefining the stem cell compartment in the adult hippocampus. Cell Stem Cell 1:481-483.
44. Tsai MJ, Chen YM, Weng CF, Liou DY, Yang HC, Chen CH, Liao RI, Kuo FS, Chiu CW, Kuo HS, et al. 2010. Enhanced expression of glycine N-methyltransferase by adenovirus-mediated gene transfer in CNS culture is neuroprotective. Ann N Y Acad Sci 1199:194-203.
45. Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S. 2006. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16:296-304.
46. Yang CP, Wang HA, Tsai TH, Fan A, Hsu CL, Chen CJ, Hong CJ, Chen YM. 2012. Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments. Eur Neuropsychopharmacol 22:596-606.
47. Yeo EJ, Wagner C. 1994. Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver. Proc Natl Acad Sci USA 91:210-214.
48. Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, et al. 2003. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci USA 100:6777-6782.
49. Zhao M, Li D, Shimazu K, Zhou YX, Lu B, Deng CX. 2007. Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. Biol Psychiatry 62:381-390.
50. Zhou B, Wang ZX, Zhao Y, Brautigan DL, Zhang ZY. 2002. The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J Biol Chem 277:31818-31825.