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Bioorganic and Medicinal Chemistry

Volumn 22, Issue 14, 2014, Pages 3720-3731

Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors

(3) Tashima, Toshihiko a Murata, Hiroaki a Kodama, Hidehiko a

a Nippon Pharmaceutical Chemicals Company Ltd (Japan)

Author keywords

Cancer; Carbostyril; Epigenetics; Histone deacetylase; Histone deacetylase inhibitor

Indexed keywords

4 (3,4 DIHYDROCARBOSTYRIL 6 YLOXY)BUTANOIC ACID HYDROXYAMIDE; 4,4 DIMETHYL 3,4 DIHYDROCARBOSTYRIL 6 CARBOXYLIC ACID[TRANS 4 (2 HYDROXYCARBAMOYLVINYL)CYCLOHEXYLMETHYL]AMIDE; 6 (3,4 DIHYDROCARBOSTYRIL 5 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (3,4 DIHYDROCARBOSTYRIL 6 YLOXY)HEXANOIC ACID ETHYL ESTER; 6 (3,4 DIHYDROCARBOSTYRIL 6 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (3,4 DIHYDROCARBOSTYRIL 7 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (3,4 DIHYDROCARBOSTYRIL 8 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (4,4 DIMETHYL 3,4 DIHYDROCARBOSTYRIL 6 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (4,4 DIMETHYL 3,4 DIHYDROCARBOSTYRIL 7 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (CARBOSTYRIL 6 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (CARBOSTYRIL 7 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (CARBOSTYRIL 8 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 6 (COUMARIN 6 YLOXY)HEXANOIC ACID HYDROXYAMIDE; 7 (3,4 DIHYDROCARBOSTYRIL 6 YLCARBAMOYL)HEPTANOIC ACID BENZYL ESTER; 7 (3,4 DIHYDROCARBOSTYRIL 6 YLCARBAMOYL)HEPTANOIC ACID HYDROXYAMIDE; 7 (CARBOSTYRIL 6 YLCARBAMOYL)HEPTANOIC ACID HYDROXYAMIDE; ANTINEOPLASTIC AGENT; CARBOSTYRIL DERIVATIVE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE 9; HISTONE DEACETYLASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; ZINC; HYDROXAMIC ACID;

ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOXICITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; LIVER; METABOLISM; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; LIVER; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902549707 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.05.001 Document Type: Article

Times cited : (36)

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