5,10-Methylene-tetrahydrofolate dissociates into tetrahydrofolate and formaldehyde at physiological pH and acidic pH, typical conditions used during sample extraction and LC-MS/MS analysis of biological samples

Biomedical Chromatography

Volumn 28, Issue 7, 2014, Pages 1041-1042

  Jagerstad, Margaretha ^a   Jastrebova, Jelena ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

5,10 CH2 H4folate; Interconversion; Stability

Indexed keywords

5,10-CH2-H4FOLATE; ACIDIC PH; BIOLOGICAL SAMPLES; CONDITION; INTERCONVERSIONS; LC-MS-MS; MS/MS ANALYSIS; PHYSIOLOGICAL PH; SAMPLE EXTRACTION; TETRAHYDROFOLATES;

PH;

ANTIOXIDANT; ASCORBIC ACID; CITRATE SODIUM; CITRATE TRISODIUM; FORMALDEHYDE; HOMOCYSTEINE; METHIONINE; METHYLENETETRAHYDROFOLIC ACID; TETRAHYDROFOLIC ACID; TETRAHYDROFOLIC ACID DERIVATIVE;

COENZYME; DISSOCIATION; EDITORIAL; FOLATE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; METHYLATION; OXIDATION; PATENT; PH; RELIABILITY; ROOM TEMPERATURE; STORAGE TEMPERATURE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS; CHEMISTRY; COLON; COLORECTAL TUMOR; FEMALE; HUMAN; MALE; PATHOLOGY; PROCEDURES; RECTUM;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLON; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; RECTUM; TANDEM MASS SPECTROMETRY; TETRAHYDROFOLATES;

EID: 84902547470     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3214     Document Type: Editorial

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