A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity

Radiotherapy and Oncology

Volumn 111, Issue 2, 2014, Pages 178-185

  Barnett, Gillian C ^a,b   Thompson, Deborah ^a   Fachal, Laura ^c   Kerns, Sarah ^d   Talbot, Chris ^e   Elliott, Rebecca M ^f   Dorling, Leila ^a   Coles, Charlotte E ^g   Dearnaley, David P ^h   Rosenstein, Barry S ^d   Vega, Ana ^c   Symonds, Paul ⁱ   Yarnold, John ^h   Baynes, Caroline ^a   Michailidou, Kyriaki ^a   Dennis, Joe ^a   Tyrer, Jonathan P ^a   Wilkinson, Jennifer S ^g   Gómez Caamaño, Antonio ^j   Tanteles, George A ^k   Platte, Radka ^a   Mayes, Rebecca ^a   Conroy, Don ^a   Maranian, Mel ^a   Luccarini, Craig ^a   Gulliford, Sarah L ^h   Sydes, Matthew R ^l   Hall, Emma ^m   Haviland, Joanne ^m   Misra, Vivek ⁿ   Titley, Jennifer ^m   Bentzen, Søren M ^o   Pharoah, Paul D P ^a   Burnet, Neil G ^b   Dunning, Alison M ^a   West, Catharine M L ^f   more..

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Santiago University Clinical Hospital   (Spain)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^h INSTITUTE OF CANCER RESEARCH   (United Kingdom)

ⁱ UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

^j HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^k CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

^l MRC CLINICAL TRIALS UNIT   (United Kingdom)

^m INSTITUTE OF CANCER RESEARCH   (United Kingdom)

ⁿ CHRISTIE HOSPITAL   (United Kingdom)

^o UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Adverse effects; Genetics; Genome wide association scan; Late toxicity; Radiotherapy

Indexed keywords

ALLELE; ARTICLE; BRACHYTHERAPY; BREAST CANCER; CANCER RADIOTHERAPY; CLINICAL TRIAL (TOPIC); EXTERNAL BEAM RADIOTHERAPY; FECES INCONTINENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; PAIN; PRIORITY JOURNAL; PROCTITIS; PROSTATE CANCER; RADIATION DOSE; RADIATION INJURY; SINGLE NUCLEOTIDE POLYMORPHISM; TELANGIECTASIA; URINE INCONTINENCE; ADJUVANT RADIOTHERAPY; ADVERSE EFFECTS; BREAST NEOPLASMS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE; PROSPECTIVE STUDY; PROSTATIC NEOPLASMS; RADIATION RESPONSE;

BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; PROSTATIC NEOPLASMS; RADIATION INJURIES; RADIOTHERAPY, ADJUVANT; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 84902545584     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2014.02.012     Document Type: Article

References (31)

1. C.M. West, and G.C. Barnett Genetics and genomics of radiotherapy toxicity: towards prediction Genome Med 3 2011 52
2. S.L. Kerns, H. Ostrer, and R. Stock et al. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer Int J Radiat Oncol Biol Phys 78 2010 1292 1300
3. S.L. Kerns, R. Stock, and N. Stone et al. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of erectile dysfunction following radiation therapy for prostate cancer Int J Radiat Oncol Biol Phys 85 2013 e21 28
4. S.L. Kerns, R.G. Stock, and N.N. Stone et al. Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer Radiother Oncol 107 2013 372 376
5. S.L. Kerns, N.N. Stone, R.G. Stock, L. Rath, H. Ostrer, and B.S. Rosenstein A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer J Urol 190 2013 102 108
6. G.C. Barnett, C.E. Coles, and R.M. Elliott et al. Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study Lancet Oncol 13 2012 65 77
7. G.C. Barnett, R.M. Elliott, and J. Alsner et al. Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity Radiother Oncol 105 2012 289 295
8. C.J. Talbot, G.A. Tanteles, and G.C. Barnett et al. A replicated association between polymorphisms near TNFalpha and risk for adverse reactions to radiotherapy Br J Cancer 107 2012 748 753
9. N.G. Burnet, R.M. Elliott, A. Dunning, and C.M. West Radiosensitivity, radiogenomics and RAPPER Clin Oncol (R Coll Radiol (Great Britain)) 18 2006 525 528
10. G.C. Barnett, C.M. West, and A.M. Dunning et al. Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype Nat Rev Cancer 9 2009 134 142
11. S.L. Kerns, D.D. Ruysscher, and C.N. Andreassen et al. STROGAR - STrengthening the Reporting Of Genetic Association studies in Radiogenomics Radiother Oncol 110 2014 182 188
12. G.C. Barnett, J.S. Wilkinson, and A.M. Moody et al. Randomized controlled trial of forward-planned intensity-modulated radiotherapy for early breast cancer: interim results at 2 years Int J Radiat Oncol Biol Phys 82 2012 715 723
13. C. Coles, and J. Yarnold The IMPORT trials are launched (September 2006) Clin Oncol (R Coll Radiol (Great Britain)) 18 2006 587 590
14. S. Martin, M. Sydenham, and J. Haviland et al. Test of association between variant tgbeta1 alleles and late adverse effects of breast radiotherapy Radiother Oncol 97 2010 15 18
15. D.P. Dearnaley, M.R. Sydes, and J.D. Graham et al. Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial Lancet Oncol 8 2007 475 487
16. D. Dearnaley, I. Syndikus, and G. Sumo et al. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial Lancet Oncol 13 2012 43 54
17. L. Fachal, A. Gomez-Caamano, and M. Sanchez-Garcia et al. TGFbeta1 SNPs and radio-induced toxicity in prostate cancer patients Radiother Oncol 103 2012 206 209
18. L. Fachal, A. Gomez-Caamano, and P. Peleteiro et al. Association of a XRCC3 polymorphism and rectum mean dose with the risk of acute radio-induced gastrointestinal toxicity in prostate cancer patients Radiother Oncol 105 2012 321 328
19. G. Giotopoulos, R.P. Symonds, and K. Foweraker et al. The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes Br J Cancer 96 2007 1001 1007
20. G.C. Barnett, C.M. West, and C.E. Coles et al. Standardized total average toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studies Int J Radiat Oncol Biol Phys 82 2011 1065 1074
21. S.L. Gulliford, K. Foo, and R.C. Morgan et al. Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: evidence from MRC RT01 trial ISRCTN 47772397 Int J Radiat Oncol Biol Phys 76 2010 747 754
22. G.C. Barnett, G. De Meerleer, S.L. Gulliford, M.R. Sydes, R.M. Elliott, and D.P. Dearnaley The impact of clinical factors on the development of late radiation toxicity: results from the medical research council RT01 trial (ISRCTN47772397) Clin Oncol (R Coll Radiol (Great Britain)) 23 2011 613 624
23. Y.S. Aulchenko, S. Ripke, A. Isaacs, and C.M. van Duijn GenABEL: an R library for genome-wide association analysis Bioinformatics (Oxford, England) 23 2007 1294 1296
24. S.M. Bentzen, M. Overgaard, and J. Overgaard Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity Eur J Cancer 29A 1993 1373 1376
25. A. Amin Al Olama, Z. Kote-Jarai, and F.R. Schumacher et al. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease Hum Mol Genet 22 2012 408 415
26. R.A. Eeles, A.A. Olama, and S. Benlloch et al. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array Nature genetics 45 2013 385 391 e381-e2
27. K. Michailidou, P. Hall, and A. Gonzalez-Neira et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk Nat Genet 45 2013 353 361 e351-e2
28. E.K. Speliotes, C.J. Willer, and S.I. Berndt et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet 42 2010 937 948
29. G.C. Barnett, J.S. Wilkinson, and A.M. Moody et al. The Cambridge Breast Intensity-modulated Radiotherapy Trial: Patient- and Treatment-related Factors that Influence Late Toxicity Clin Oncol (R Coll Radiol (Great Britain)) 23 2011 662 673
30. C.N. Andreassen, G.C. Barnett, and J.A. Langendijk et al. Conducting radiogenomic research - do not forget careful consideration of the clinical data Radiother Oncol 105 2012 337 340
31. C. West, B.S. Rosenstein, and J. Alsner et al. Establishment of a radiogenomics consortium Int J Radiat Oncol Biol Phys 76 2010 1295 1296