Test of association between variant tgβ1 alleles and late adverse effects of breast radiotherapy

Radiotherapy and Oncology

Volumn 97, Issue 1, 2010, Pages 15-18

  Martin, Susan ^a   Sydenham, Mark ^b   Haviland, Joanne ^b   A'Hern, Roger ^b   Owen, Roger ^c   Bliss, Judith ^b   Yarnold, John ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c Gloucestershire Oncology Centre   (United Kingdom)

Author keywords

Adverse effects; Ionising radiation; Mutation; Normal tissue damage; Radiotherapy; Single nucleotide polymorphisms

Indexed keywords

ANTINEOPLASTIC AGENT; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CLINICAL ASSESSMENT; CODON; CONTROLLED STUDY; EXON; FEMALE; FOLLOW UP; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MEDICAL PHOTOGRAPHY; PRIORITY JOURNAL; PROMOTER REGION; RADIATION DOSE FRACTIONATION; RETROSPECTIVE STUDY; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CODON; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; GENETIC VARIATION; GENOTYPE; HUMANS; PHENOTYPE; PHOTOGRAPHY; POLYMORPHISM, SINGLE NUCLEOTIDE; RADIATION TOLERANCE; RADIOTHERAPY; RADIOTHERAPY DOSAGE; RETROSPECTIVE STUDIES;

EID: 77957867486     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2010.03.019     Document Type: Article

References (18)

1. J. Alsner, C.N. Andreassen, and J. Overgaard Genetic markers for prediction of normal tissue toxicity after radiotherapy Semin Radiat Oncol 18 2008 126 135
2. C.N. Andreassen, and J. Alsner Genetic variants and normal tissue toxicity after radiotherapy: a systematic review Radiother Oncol 92 2009 299 309
3. C.N. Andreassen, J. Alsner, and J. Overgaard Does variability in normal tissue reactions after radiotherapy have a genetic basis - where and how to look for it? Radiother Oncol 64 2002 131 140
4. C.N. Andreassen, J. Alsner, and J. Overgaard TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer Radiother Oncol 75 2005 18 21
5. C.N. Andreassen, J. Alsner, M. Overgaard, and J. Overgaard Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes Radiother Oncol 69 2003 127 135
6. C.N. Andreassen, J. Alsner, M. Overgaard, F.B. Sorensen, and J. Overgaard Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATMndash; a study based on DNA from formalin fixed paraffin embedded tissue samples Int J Radiat Biol 82 2006 577 586
7. M. Baumann,.T. Holscher, and A.C. Begg Towards genetic prediction of radiation responses: ESTRO's GENEPI project Radiother Oncol 69 2003 121 125
8. S.M. Bentzen, R.K. Agrawal, and E.G. Aird The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial Lancet Oncol 9 2008 331 341
9. S.M. Bentzen, and J. Overgaard Patient-to-patient variability in the expression of radiation-induced normal tissue injury Semin Radiat Oncol 4 1994 68 80
10. K. De Ruyck, M. Van Eijkeren, and K. Claes TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors Int J Radiat Oncol Biol Phys 65 2006 1240 1248
11. E. Donovan, N. Bleakley, and E. Denholm Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy Radiother Oncol 2007
12. A.M. Dunning, C.S. Healey, P.D. Pharoah, M.D. Teare, B.A. Ponder, and D.F. Easton A systematic review of genetic polymorphisms and breast cancer risk Cancer Epidemiol Biomarkers Prev 8 1999 843 854
13. K.A. Frazer, S.S. Murray, N.J. Schork, and E.J. Topol Human genetic variation and its contribution to complex traits Nat Rev Genet 10 2009 241 251
14. O. Popanda, J.U. Marquardt, J. Chang-Claude, and P. Schmezer Genetic variation in normal tissue toxicity induced by ionizing radiation Mutat Res 2008
15. S. Quarmby, H. Fakhoury, and E. Levine Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients Int J Radiat Biol 79 2003 137 143
16. A. Safwat, S.M. Bentzen, I. Turesson, and J.H. Hendry Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy Int J Radiat Oncol Biol Phys 52 2002 198 204
17. I. Turesson, J. Nyman, E. Holmberg, and A. Oden Prognostic factors for acute and late skin reactions in radiotherapy patients Int J Radiat Oncol Biol Phys 36 1996 1065 1075
18. J. Yarnold, A. Ashton, and J. Bliss Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial Radiother Oncol 75 2005 9 17